Blar i Bergen Open Research Archive på forfatter "Bostad, Leif"
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The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication
Brügger-Andersen, Trygve; Bostad, Leif; Sandnes, Dagny A.; Larsen, Alf Inge; Bonarjee, Vernon V. S.; Barvik, Ståle; Melberg, Tor; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2010-01-27)Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation ... -
AGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease
Strauss, Philipp; Marti, Hans-Peter; Furriol, Jessica; Nakken, Sigrid; Vidar, Beisvåg; Eikrem, Øystein Solberg; Beisland, Christian; Flatberg, Arnar; Bostad, Leif; Scherer, Andreas; Eleni, Skandalou (Journal article; Peer reviewed, 2021)Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and ... -
The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
Aarstad, Helene Hersvik; Gudbrandsdottir, Gigja; Hjelle, Karin; Bostad, Leif; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ... -
Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study
Sriskandarajah, Sanjeevan; Bostad, Leif; Myklebust, Tor Åge; Møller, Bjørn; Skrede, Steinar; Bjørneklett, Rune (Peer reviewed; Journal article, 2017-12-18)Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary ... -
Impact of proteinase 3 versus myeloperoxidase positivity on risk of end-stage renal disease in ANCA-associated glomerulonephritis stratified by histological classification: A population-based cohort study
Solbakken, Vilde; Fismen, Anne-Siri; Bostad, Leif; Bjørneklett, Rune (Peer reviewed; Journal article, 2018-05-09)Background: End-stage renal disease (ESRD) risk in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis (ANCA-GN) according to ANCA serotype and stratified by histological classification ... -
The levels of IL-6 and soluble IL-33R are increased in the renal vein during surgery for clear cell renal cell carcinoma
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Hjelle, Karin Margrethe; Førde, Kristina; Reisæter, Lars Anders Rokne; Bostad, Leif; Aarstad, Hans Jørgen; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose The main aim was to map serum levels of IL-1/IL-6 family cytokines and relevant receptors from serum samples taken across treatment in patients with Renal Cell Carcinoma (RCC). Additionally, we explored the possible ... -
National Norwegian Practice Patterns for Surgical Treatment of Kidney Cancer Tumors ≤7 cm: Adherence to Changes in Guidelines May Improve Overall Survival
Hjelle, Karin Margrethe; Johannesen, Tom B.; Bostad, Leif; Reisæter, Lars A. R.; Beisland, Christian (Peer reviewed; Journal article, 2018-08)Background: Guidelines on surgical treatment for kidney cancer (KC) have changed over the last 10 yr. We present population-based data for patients with KC tumors ≤7 cm from 2008 to 2013 to investigate whether surgical ... -
pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda
Kalungi, Sam; Steine, Solrun; Wabinga, Henry; Bostad, Leif; Molven, Anders (Peer reviewed; Journal article, 2009-08-19)Background: The members of the retinoblastoma protein family, pRb, p107 and pRb2 (p130), are central players in controlling the cell cycle. Whereas disturbed function of pRb is commonly seen in human cancers, it is still ... -
Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study
Bjørneklett, Rune; Bostad, Leif; Fismen, Anne-Siri (Peer reviewed; Journal article, 2018-05-31)Background. The value of a histologic classification scheme to classify patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into focal, mixed, crescentic, and sclerotic types for ... -
Prognostic factors in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with severe glomerular sclerosis: a national registry-based cohort study
Bjørneklett, Rune; Solbakken, Vilde; Bostad, Leif; Fismen, Anne-Siri (Peer reviewed; Journal article, 2018-06-03)Background. Classification of patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into histological classes is useful for predicting a patient’s risk of progression to end-stage renal ... -
The prognostic relevance of interactions between venous invasion, lymph node involvement and distant metastases in renal cell carcinoma after radical nephrectomy
Zubac, Dragomir; Bostad, Leif; Seidal, Tomas; Wentzel-Larsen, Tore; Haukaas, Svein Andreas (Peer reviewed; Journal article, 2008-12-19)Background: To investigate a possible prognostic significance of interactions between lymph node invasion (LNI), synchronous distant metastases (SDM), and venous invasion (VI) adjusted for mode of detection, Eastern ... -
Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study
Voltersvik, Pål; Aqrawi, Lara Adnan; Dudman, Susanne Gjeruldsen; Hungnes, Olav; Bostad, Leif; Brokstad, Karl Albert; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-11)Background: During the pandemic outbreak of the 2009 swine influenza (A(H1N1) pdm09), 32 fatal cases occurred in Norway and 19 of these were included in this study. Objectives: We characterised pulmonary changes in these ... -
Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC)
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Bostad, Leif; Hjelle, Karin; Aarstad, Hans Jørgen; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)Purpose An improved understanding of RCC immunology should shed further light on RCC tumor biology. Our objective was to study to what extent serum levels of the IL-6 family of cytokines at diagnosis were relevant to ... -
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
Zubac, Dragomir; Wentzel-Larsen, Tore; Seidal, Tomas; Bostad, Leif (Peer reviewed; Journal article, 2010-12-03)Background To examine the expression of type 1 plasminogen inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC), and its possible association with microvessel density (MVD), the expression of thrombospondin-1 ... -
Utilizing the MEST score for prognostic staging in IgA nephropathy
Haaskjold, Yngvar Lunde; Bjørneklett, Rune Oskar; Bostad, Leif; Bostad, Lars Sigurd; Lura, Njål Gjærde; Knoop, Thomas (Journal article; Peer reviewed, 2022)Background The Oxford classification/MEST score is an established histopathologic scoring system for patients with IgA nephropathy (IgAN). The objective of this study was to derive a prognostic model for IgAN based on the ...