Browsing Bergen Open Research Archive by Author "Brun, Johan Gorgas"

Now showing items 1-10 of 10

    • Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation 

      Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Petrovic, Aleksandra; Joshi, Anagha; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Appel, Silke (Journal article; Peer reviewed, 2022)
      Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity ...

    • Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome 

      Vogelsang, Petra; Karlsen, Marie; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2014-08-11)
      Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ...

    • A five-year prospective study of fatigue in primary Sjögren’s syndrome 

      Haldorsen, Karstein; Bjelland, Ingvar; Bolstad, Anne Isine; Jonsson, Roland; Brun, Johan Gorgas (Peer reviewed; Journal article, 2011-10-13)
      Introduction: Fatigue is prevalent in primary Sjögren’s syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and ...

    • Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren’s syndrome 

      Norheim, Katrine Brække; Imgenberg-Kreuz, Juliana; Alexsson, Andrei; Johnsen, Svein Joar Auglæn; Bårdsen, Kjetil; Brun, Johan Gorgas; Dehkordi, Rezvan Kiani; Theander, Elke; Mandl, Thomas; Jonsson, Roland; Ng, Wan-Fai; Lessard, Christopher J; Rasmussen, Astrid; Sivilis, Kathy; Rönnblom, Lars; Omdal, Roald (Journal article; Peer reviewed, 2021)
      Objectives Fatigue is common and severe in primary Sjögren’s syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study. Methods Patients with ...

    • Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells 

      Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna; Adler, Adam; Alevizos, Ilias; Anaya, Juan-Manuel; Aqrawi, Lara A.; Baecklund, Eva; Brun, Johan Gorgas; Bucher, Sara Magnusson; Eloranta, Maija-Leena; Engelke, Fiona; Forsblad-d’Elia, Helena; Glenn, Stuart B.; Hammenfors, Daniel; Imgenberg-Kreuz, Juliana; Jensen, Janicke Liaaen; Johnsen, Svein Joar Auglæn; Jonsson, Malin Viktoria; Kvarnström, Marika; Kelly, Jennifer A.; Li, He; Mandl, Thomas; Martín, Javier; Nocturne, Gaétane; Norheim, Katrine Brække; Palm, Øyvind; Skarstein, Kathrine; Stolarczyk, Anna M.; Taylor, Kimberly E.; Teruel, Maria; Theander, Elke; Venuturupalli, Swamy; Wallace, Daniel J.; Grundahl, Kiely M.; Hefner, Kimberly S.; Radfar, Lida; Lewis, David M.; Stone, Donald U.; Kaufman, C. Erick; Brennan, Michael T.; Guthridge, Joel M.; James, Judith A.; Scofield, R. Hal; Gaffney, Patrick M.; Criswell, Lindsey A.; Jonsson, Roland; Eriksson, Per; Bowman, Simon J.; Omdal, Roald; Rönnblom, Lars; Warner, Blake; Rischmueller, Maureen; Witte, Torsten; Farris, A. Darise; Mariette, Xavier; Alarcon-Riquelme, Marta E.; Shiboski, Caroline H.; Herlenius, Marie Elisabeth Wahren; Ng, Wan-Fai; Sivils, Kathy L.; Adrianto, Indra; Nordmark, Gunnel; Lessard, Christopher J. (Journal article; Peer reviewed, 2022)
      Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ...

    • Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome 

      Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Lyssenko, Valeriya; Appel, Silke (Journal article; Peer reviewed, 2022)
      Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. ...

    • In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome 

      Volchenkov, Roman; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2013-09-09)
      Introduction: Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the ...

    • The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab 

      Nordal, Hilde Haugedal; Brun, Johan Gorgas; Halse, Anne-Kristine; Jonsson, Roland; Fagerhol, Magne Kristoffer; Hammer, Hilde Berner (Peer reviewed; Journal article, 2014-10-04)
      Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...

    • Reduced Joint Pain after Short-term Duodenal Administration of Seal Oil in Patients with Inflammatory Bowel Disease: Comparison with Soy Oil 

      Bjørkkjær, Tormod; Brunborg, Linn Anne; Arslan, Gülen; Lind, Ragna Anne; Brun, Johan Gorgas; Valen, Merete; Klementsen, Beate; Berstad, Arnold; Frøyland, Livar (Peer reviewed; Journal article, 2004)
      Background: Rheumatic joint pain is a common extraintestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, ...

    • Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease 

      Bjørkkjær, Tormod; Brun, Johan Gorgas; Valen, Merete; Arslan, Gülen; Lind, Ragna Anne; Brunborg, Linn Anne; Berstad, Arnold; Frøyland, Livar (Peer reviewed; Journal article, 2006-03-20)
      Background: A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10- day) duodenal administration of ...