Browsing Bergen Open Research Archive by Author "Cristea, Ileana"
Now showing items 1-6 of 6
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Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID)
Mehrasa, Roya; Cristea, Ileana; Bredrup, Cecilie; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2023)All-trans retinoic acid-induced differentiation (ATRAID) factor was first identified in HL60 cells. Several mRNA isoforms exist, but the respective proteins have not been fully characterized. In transfected cells expressing ... -
K+ regulates relocation of Pellino-2 to the site of NLRP3 inflammasome activation in macrophages
Cristea, Ileana; Bruland, Ove; Rødahl, Eyvind; Bredrup, Cecilie (Journal article; Peer reviewed, 2021)Pellino proteins are E3 ubiquitin ligases involved in the innate immune system. Recently, Pellino-2 was reported to modulate the activation of the mouse Nlrp3 inflammasome. We examined the intracellular localization of ... -
Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization
Cristea, Ileana; Bruland, Ove; Rødahl, Eyvind; Bredrup, Cecilie (Journal article; Peer reviewed, 2021)Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid ... -
Pellino-2 intracellular localization and inflammasome overactivation in skin and corneal disease
Cristea, Ileana (Doctoral thesis, 2021-12-17)Background: Ocular pterygium-digital keloids dysplasia (OPDKD) is a rare, genetic disorder characterized by early onset corneal overgrowth and later development of keloids on distal limbs. We identified a de novo PELI2 ... -
A Pellino-2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia
Cristea, Ileana; Abarca, Hugo; Christensen, Anne Elisabeth; Trubnykova, Milana; Mehrasa, Roya; Peters, Dorien J. M.; Houge, Gunnar Douzgos; Hennekam, Raoul C. M.; Rødahl, Eyvind; Bruland, Ove; Bredrup, Cecilie (Journal article; Peer reviewed, 2023)Ocular pterygium–digital keloid dysplasia (OPDKD) is a rare hereditary disease characterized by corneal ingrowth of vascularized conjunctival tissue early in life. Later, patients develop keloids on fingers and toes but ... -
Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions
Bredrup, Cecilie; Cristea, Ileana; Safieh, Leen Abu; Di Maria, Emilio; Gjertsen, Bjørn Tore; Tveit, Kåre Steinar; Thu, Frode; Bull, Nils; Edward, Deepak P.; Hennekam, Raoul C.; Høvding, Gunnar Jr; Haugen, Olav H.; Houge, Gunnar Douzgos; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2021)Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are ...