Blar i Bergen Open Research Archive på forfatter "Denault, William Robert Paul"

Viser treff 1-11 av 11

    • Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 

      Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)
      Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ...

    • Cross-fitted instrument: A blueprint for one-sample Mendelian randomization 

      Denault, William Robert Paul; Bohlin, Jon; Page, Christian Magnus; Burgess, Stephen; Jugessur, Astanand (Journal article; Peer reviewed, 2022-08-29)
      Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the application of a new ...

    • Detecting diferentially methylated regions using a fast wavelet‑based approach to functional association analysis 

      Denault, William Robert Paul; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background We present here a computational shortcut to improve a powerful wavelet-based method by Shim and Stephens (Ann Appl Stat 9(2):665–686, 2015. https://doi.org/10.1214/14-AOAS776) called WaveQTL that was originally ...

    • DNA methylation in newborns conceived by assisted reproductive technology 

      Håberg, Siri Eldevik; Page, Christian Magnus; Lee, Yunsung; Nustad, Haakon Egdetveit; Magnus, Maria Christine; Haftorn, Kristine Løkås; Carlsen, Ellen Øen; Denault, William Robert Paul; Bohlin, Jon; Jugessur, Astanand; Magnus, Per Minor; Gjessing, Håkon Kristian; Lyle, Robert (Journal article; Peer reviewed, 2022)
      Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo ...

    • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 

      Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)
      Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ...

    • Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents 

      Lubczyńska, Małgorzata J.; Muetzel, Ryan L.; El Marroun, Hanan; Basagaña, Xavier; Strak, Maciej; Denault, William Robert Paul; Jaddoe, Vincent W.V.; Hillegers, Manon; Vernooij, Meike W.; Hoek, Gerard; White, Tonya; Brunekreef, Bert; Tiemeier, Henning; Guxens, Mònica (Journal article; Peer reviewed, 2020)
      Background: Air pollution has been related to brain structural alterations, but a relationship with white matter microstructure is unclear. Objectives: We assessed whether pregnancy and childhood exposures to air ...

    • A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population 

      Denault, William Robert Paul; Romanowska, Julia; Helgeland, Øyvind; Jacobsson, Bo; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW has increased dramatically since ...

    • Nucleated red blood cells explain most of the association between DNA methylation and gestational age 

      Haftorn, Kristine Løkås; Denault, William Robert Paul; Lee, Yunsung; Page, Christian Magnus; Romanowska, Julia; Lyle, Robert; Næss, Øyvind Erik; Kristjansson, Dana; Magnus, Per Minor; Håberg, Siri Eldevik; Bohlin, Jon; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ...

    • Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts 

      Denault, William Robert Paul; Romanowska, Julia; Haaland, Øystein Ariansen; Lyle, Robert; Taylor, Jack A.; Xu, Zongli; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      DNA methylation is the most widely studied epigenetic mark in humans and plays an essential role in normal biological processes as well as in disease development. More focus has recently been placed on understanding ...

    • Wavelet Screening: a novel approach to analyzing GWAS data 

      Denault, William Robert Paul; Gjessing, Håkon K.; Juodakis, Julius; Jacobsson, Bo; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background Traditional methods for single-variant genome-wide association study (GWAS) incur a substantial multiple-testing burden because of the need to test for associations with a vast number of single-nucleotide ...

    • The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome? 

      Romanowska, Julia; Nustad, Haakon Egdetveit; Page, Christian Magnus; Denault, William Robert Paul; Lee, Yunsung; Magnus, Maria Christine; Haftorn, Kristine Løkås; Gjerdevik, Miriam; Novakovic, Boris; Saffery, Richard; Gjessing, Håkon K.; lyle, robert; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Background Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated ...