Blar i Bergen Open Research Archive på forfatter "Dyrhol-Riise, Anne Ma"
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Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery
Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019)Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, virally ... -
Adenosine Deaminase Activity Is a Sensitive Marker for the Diagnosis of Tuberculous Pleuritis in Patients with Very Low CD4 Counts
Baba, Kamaldeen; Hoosen, Anwar A.; Langeland, Nina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2008-07-30)Background: Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive ... -
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID‑19
Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Stiksrud, Birgitte; Berge, Tone; Barratt-Due, Andreas; Aukrust, Pål; Heggelund, Lars; Blennow, Kaj; Zetterberg, Henrik; Harbo, Hanne Flinstad; Quist‑Paulsen, Else (Journal article; Peer reviewed, 2021)Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for ... -
Burden and characteristics of the comorbidity tuberculosis - diabetes in Europe : TBnet prevalence survey and case-control study
Sane Schepisi, Monica; Navarra, Assunta; Altet Gómez, Maria de las Nieves; Dudnyk, Andrii; Dyrhol-Riise, Anne Ma; Esteban, Jaime; Giorgetti, Pier Francesco; Gualano, Gina; Guglielmetti, Lorenzo; Heyckendorf, Jan; Kaluzhenina, Anna; Lange, Berit; Lange, Christoph; Manika, Katerina; Miah, Jalal; Nanovic, Zorica; Pontali, Emanuele; Prego, Monica Rios; Solovič, Ivan; Tiberi, Simon; Palmieri, Fabrizio; Girardi, Enrico (Peer reviewed; Journal article, 2019-01)Background: The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment ... -
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2016-10-24)Background: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. ... -
Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice
Mortensen, Rasmus; Clemmensen, Helena Strand; Woodworth, Joshua S.; Therkelsen, Marie Louise; Mustafa, Tehmina; Tonby, Kristian; Jenum, Synne; Agger, Else Marie; Dyrhol-Riise, Anne Ma; Andersen, Peter (Peer reviewed; Journal article, 2019)Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health ... -
Cytokine Patterns in Tuberculosis Infection; IL-1ra, IL-2 and IP-10 Differentiate Borderline QuantiFERON-TB Samples from Uninfected Controls
Wergeland, Ida; Assmus, Jörg; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2016-09-29)Background: Interferon gamma release assays (IGRAs) do not discriminate between active tuberculosis (TB) and latent TB infection (LTBI), which limit their use in TB endemic areas. Subjects with QuantiFERON-TB (QFT) results ... -
Diagnosis and follow-up of treatment of latent tuberculosis; the utility of the QuantiFERON-TB Gold In-tube assay in outpatients from a tuberculosis low-endemic country
Dyrhol-Riise, Anne Ma; Gran, Gerd; Wentzel-Larsen, Tore; Blomberg, Bjørn; Haanshuus, Christel Gill; Mørkve, Odd (Peer reviewed; Journal article, 2010-03-08)Background Interferon-gamma (IFN-γ) Release Assays (IGRA) are more specific than the tuberculosis skin test (TST) in the diagnosis of latent tuberculosis (TB) infection (LTBI). We present the performance of the QuantiFERON®-TB ... -
Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting
Hoel, Ida Marie; Sviland, Lisbeth; Syre, Heidi; Dyrhol-Riise, Anne Ma; Skarstein, Ingerid; Jebsen, Peter Wilhelm; Jørstad, Melissa Davidsen; Wiker, Harald G; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Background Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the paucibacillary nature of the disease. The immunochemistry-based MPT64 antigen detection test (MPT64 test) has shown promising results ... -
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor; Michelsen, Annika; Otterdal, Kari; Muller, Karl Erik; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma; Holter, Jan Cato; Trøseid, Marius (Journal article; Peer reviewed, 2021)Background A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin ... -
Evaluation of immune responses in HIV infected patients with pleural tuberculosis by the QuantiFERON® TB-Gold interferon-gamma assay
Baba, Kamaldeen; Sørnes, Steinar; Hoosen, Anwar A.; Lekabe, Jacob M.; Mpe, Mathew J.; Langeland, Nina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2008-03-14)Background: Diagnosis of tuberculous (TB) pleuritis is difficult and better diagnostic tools are needed. New blood based interferon-gamma (IFN-γ) tests are promising, but sensitivity could be low in HIV positive patients. ... -
Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting
Jørstad, Melissa Davidsen; Dyrhol-Riise, Anne Ma; Aßmus, Jörg; Marijani, Msafiri; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2019-05-16)Background Diagnosing extrapulmonary tuberculosis (EPTB) is challenging and many patients are initiated on empirical anti-TB treatment without a laboratory confirmed diagnosis. Monitoring treatment response is thus important ... -
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2018-11-23)Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ... -
HIV patients with latent tuberculosis living in a low-endemic country do not develop active disease during a 2 year follow-up; a Norwegian prospective multicenter study
Pullar, Nadine Durema; Steinum, Harald; Bruun, Johan Nikolai; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2014-12-17)Background: Interferon-γ release assays (IGRA) serve as immunodiagnostics of tuberculosis (TB) infection to identify individuals with latent TB infection (LTBI) eligible for preventive anti-TB therapy. In this longitudinal ... -
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (Peer reviewed; Journal article, 2017-05-02)Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ... -
In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry
Mekonnen, Meseret Habtamu; Abebe, Markos; Aseffa, Abraham; Dyrhol-Riise, Anne Ma; Spurkland, Anne; Abrahamsen, Greger (Peer reviewed; Journal article, 2018)There is a lack of suitable correlates of immune protection against Mycobacterium tuberculosis (Mtb) infection. T cells and monocytes play key roles in host immunity against Mtb. Thus, a method that allows assessing their ... -
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian; Pischke, Soeren; Jenum, Synne; Skeie, Linda Gail; Nur, Sarah; Lind, Andreas; Opsand, Hanne; Enersen, Tone Burvald; Grøndahl, Ragnhild; Hermann, Anne; Dudman, Susanne Gjeruldsen; Müller, Fredrik; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2020-12)In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and ... -
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2015-04)Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ... -
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting
Hoel, Ida Marie; Jørstad, Melissa Davidsen; Marijani, Msafiri; Ruhwald, Morten; Mustafa, Tehmina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019-03-07)Treatment efficacy is difficult to evaluate in extrapulmonary tuberculosis (EPTB) patients. Interferon-γ inducible protein (IP-)10 has been suggested as a biomarker for response to treatment. We have investigated if IP-10 ... -
MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar
Jørstad, Melissa Davidsen; Marijani, Msafiri; Dyrhol-Riise, Anne Ma; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2018-05-09)Background: Extrapulmonary tuberculosis (EPTB) is a diagnostic challenge. An immunochemistry-based MPT64 antigen detection test (MPT64 test) has reported higher sensitivity in the diagnosis of EPTB compared with conventional ...