Blar i Bergen Open Research Archive på forfatter "Elsaid, Hassan Osman Alhassan"
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Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ... -
Fabry disease model in Zebrafish : Studying molecular mechanisms of Fabry nephropathy in a Gb3-free environment
Elsaid, Hassan Osman Alhassan (Doctoral thesis, 2023-03-21)Bakgrunn: Fabry sykdom (FS) er en X-bundet lysosomal avleiringssykdom betinget i mutasjon i alfa-galactosidase genet (GLA). Enzymet alfa-galactosidase A (α-GAL) er ansvarlig for nedbryting av fettstoffet globotriaocylceramid ... -
Functional analysis of the nonvisual opsins melanopsin and vertebrate ancient opsin (VA opsin) in Atlantic salmon (Salmo salar)
Elsaid, Hassan Osman Alhassan (Master thesis, 2017-06-15)The role of nonvisual photoreceptors is yet to be elucidated regarding the link to biological function. This study aims to characterise the expression pattern of melanopsin and vertebrate ancient opsin during early ... -
Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca2+ Signaling Similar to Fabry Disease
Elsaid, Hassan Osman Alhassan; Tjeldnes, Håkon; Rivedal, Mariell Lossius; Serre, Camille Julia; Eikrem, Øystein Solberg; Svarstad, Einar; Tøndel, Camilla; Marti, Hans Peter; Furriol, Jessica; Babickova, Janka (Journal article; Peer reviewed, 2022)Fabry disease (FD) is an X-linked inborn metabolic disorder due to partial or complete lysosomal α-galactosidase A deficiency. FD is characterized by progressive renal insufficiency and cardio- and cerebrovascular involvement. ... -
Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease
Elsaid, Hassan Osman Alhassan; Rivedal, Mariell Lossius; Skandalou, Eleni; Svarstad, Einar; Tøndel, Camilla; Birkeland, Even; Eikrem, Øystein Solberg; Babickova, Janka; Marti, Hans Peter; Furriol, Jessica (Journal article; Peer reviewed, 2023)Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ... -
Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype
Elsaid, Hassan Osman Alhassan; Furriol, Jessica; Blomqvist, Maria; Diswall, Mette; Leh, Sabine; Gharbi, Naouel; Anonsen, Jan Haug; Babickova, Janka; Tøndel, Camilla; Svarstad, Einar; Marti, Hans Peter; Krause, Maximilian (Journal article; Peer reviewed, 2022)Fabry disease (FD) is a rare genetic lysosomal storage disorder, resulting from partial or complete lack of alpha-galactosidase A (α-GAL) enzyme, leading to systemic accumulation of substrate glycosphingolipids with a broad ...