Blar i Bergen Open Research Archive på forfatter "Fevang, Børre"
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Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis
Holmøy, Trygve; Fevang, Børre; Olsen, David Benee; Spigset, Olav; Bø, Lars (Peer reviewed; Journal article, 2019-08-12)Objective: Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of ... -
Clinical characteristics and factors affecting disease severity in hospitalized tick-borne encephalitis patients in Norway from 2018 to 2022
Skudal, Hilde Kristin; Lorentzen, Åslaug Rudjord; Stenstad, Tore; Paulsen, Else Quist; Egeland, Jens; Fevang, Børre; Jaioun, Keson; Hansen, Bjørn Åsheim; Solheim, Anne Marit; Tveten, Yngvar; Veje, Malin; Eikeland, Randi; Kersten, Hege (Journal article; Peer reviewed, 2024)Purpose To describe the clinical characteristics and factors associated with disease severity in a Norwegian cohort of hospitalized patients with tick-borne encephalitis (TBE). Methods This observational multicenter study ... -
Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances
Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Skarpengland, Tonje; Berge, Rolf Kristian; Fevang, Børre; Halvorsen, Bente; Aukrust, Pål (Journal article; Peer reviewed, 2023)The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity ... -
Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency
Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin; Otterdal, Kari; Holm, Kristian; Berge, Rolf Kristian; Mollnes, Tom Eirik; Trøseid, Marius; Halvorsen, Bente; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2020)A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ... -
High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19
Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Peer reviewed, 2022)Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but ... -
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Peer reviewed; Journal article, 2019-07-01)Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ... -
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
Macpherson, Magnhild Eide; Skarpengland, Tonje; Hov, Johannes Espolin Roksund; Ranheim, Trine; Vestad, Beate; Dahl, Tuva Børresdatter; Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Holven, Kirsten Bjørklund; Fevang, Børre; Berge, Rolf Kristian; Aukrust, Pål; Halvorsen, Bente; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2023)Purpose: Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have inflammatory complications ... -
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies
Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen; Yang, Kuan; Quiles Jimenez, Ana Maria Teresa; Heggelund, Lars; Muller, Karl Erik; Tveita, Anders Aune; Michelsen, Annika Elisabet; Bøe, Simen; Holten, Aleksander Rygh; Hoel, Hedda Benedicte; Mathiessen, Alexander; Aaløkken, Trond Mogens; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Nezvalova-Henriksen, Katerina; Lerum, Tøri Vigeland; Müller, Fredrik; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Ueland, Thor (Journal article; Peer reviewed, 2022)Background: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. Objectives: To investigate ... -
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ... -
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria
Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Fevang, Børre; Aukrust, Pål; Langeland, Nina; Ueland, Thor (Peer reviewed; Journal article, 2018-12-18)BACKGROUND: The immune response during P. falciparum infection is a two-edged sword, involving dysregulation of the inflammatory responses with several types of immune cells participating. Here we examined T-cell, ... -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne; Holten, Aleksander Rygh; Tonby, Kristian; Barratt-Due, Andreas; Sokolova, Marina; Schjalm, Camilla; Chaban, Viktoriia; Kolderup, Anette; Tran, Trung; Tollefsrud Gjølberg, Torleif; Skeie, Linda Gail; Hesstvedt, Liv; Ormåsen, Vidar; Fevang, Børre; Austad, Cathrine; Muller, Karl Erik; Fladeby, Cathrine; Holberg-Petersen, Mona; Halvorsen, Bente; Müller, Fredrik; Aukrust, Pål; Dudman, Susanne Gjeruldsen; Ueland, Thor; Andersen, Jan Terje; Lund-Johansen, Fridtjof; Heggelund, Lars; Dyrhol-Riise, Anne Ma; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2020)Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ...