Blar i Bergen Open Research Archive på forfatter "Holmøy, Trygve"

Viser treff 1-20 av 27

    • Abuse and revictimization in adulthood in multiple sclerosis: a cross-sectional study during pregnancy 

      Eid, Karine; Torkildsen, Øivind; Aarseth, Jan Harald; Celius, Elisabeth Gulowsen; Cortese, Marianna; Holmøy, Trygve; Kapali, Akash; Myhr, Kjell-Morten; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)
      Background: Knowledge concerning exposure to abuse in adulthood and in pregnancy in people with multiple sclerosis (MS) is sparse. Objective: To determine the occurrence of adult abuse and abuse in relation to pregnancy ...

    • Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis 

      Holmøy, Trygve; Fevang, Børre; Olsen, David Benee; Spigset, Olav; Bø, Lars (Peer reviewed; Journal article, 2019-08-12)
      Objective: Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of ...

    • Alpha-tocopherol and MRI outcomes in multiple sclerosis - association and prediction 

      Løken-Amsrud, Kristin Ingeleiv; Myhr, Kjell-Morten; Bakke, Søren Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Bjørnarå, Bård T.; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve (Peer reviewed; Journal article, 2013-01-22)
      Objective: Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship ...

    • Assessing amyotrophic lateral sclerosis prevalence in Norway from 2009 to 2015 from compulsory nationwide health registers 

      Nakken, Ola; Lindstrøm, Jonas Christoffer; Tysnes, Ole-Bjørn; Holmøy, Trygve (Peer reviewed; Journal article, 2017)
      Objective: In Norway, diagnoses from specialist health care visits, drug prescriptions, and causes of deaths are registered in compulsory health registers. We aimed to determine amyotrophic lateral sclerosis (ALS) prevalence ...

    • Association of adverse childhood experiences with the development of multiple sclerosis 

      Eid, Karine; Torkildsen, Øivind; Aarseth, Jan Harald; Aalstad, Mari; Bhan, Alok; Celius, Elisabeth Gulowsen; Cortese, Marianna; Daltveit, Anne Kjersti Nesje; Holmøy, Trygve; Myhr, Kjell-Morten; Riise, Trond; Schuler, Stephan; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)
      Objective To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development. Methods A nationwide, prospective cohort study based on participants ...

    • The Effect of Smoking on Long-term Gray Matter Atrophy and Clinical Disability in Patients with Relapsing-Remitting Multiple Sclerosis 

      Lie, Ingrid Anne; Wesnes, Kristin; Kvistad, Silje S.; Brouwer, Iman; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne-Cathrin Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Barkhof, Frederik; Vrenken, Hugo; Myhr, Kjell-Morten; Bø, Lars; Torkildesen, Øivind (Journal article; Peer reviewed, 2022)
      Background and Objectives The relationship between smoking, long-term brain atrophy, and clinical disability in patients with multiple sclerosis (MS) is unclear. Here, we assessed long-term effects of smoking by evaluating ...

    • G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis 

      Tomescu-Baciu, Alina; Vartdal, Frode; Holmøy, Trygve; Vedeler, Christian A.; Lossius, Peter Andreas Vold (Peer reviewed; Journal article, 2018-09-17)
      We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally ...

    • Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study 

      Olsen, Cathrine Goberg; Busk, Øyvind Løvold; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjørnå, Ingrid Kristine; Braathen, Geir Julius; Breivik, Kristin Lif; Demic, Natasha; Flemmen, Heidi Øyen; Hallerstig, Erika; HogenEsch, Ineke; Holla, Øystein Lunde; Jøntvedt, Anne Berit; Kampman, Margitta T.; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Åse Hagen; Nakken, Ola; Novy, Camilla; Rekand, Tiina; Schlüter, Katrin Ruth; Schuler, Stephan; Tveten, Kristian; Tysnes, Ole-Bjørn; Holmøy, Trygve; Høyer, Helle (Journal article; Peer reviewed, 2022)
      Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ...

    • Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis – a pilot trial 

      Storm-Larsen, Christopher; Myhr, Kjell-Morten; Farbu, Elisabeth; Midgard, Rune; Nyquist, Kaja Beate; Broch, Line; Berg-Hansen, Pål; Hov, Johannes Espolin Roksund; Holmøy, Trygve (Peer reviewed; Journal article, 2019)
      Introduction: Patients with multiple sclerosis may have a distinct gut microbiota profile. Delayed-release dimethyl fumarate is an orally administered drug for relapsing–remitting multiple sclerosis, which has been associated ...

    • Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations 

      König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine; Vaage, Eline Benno; Mygland, Åse Daasvand; Wergeland, Stig; Aarseth, Jan Harald; Aaberge, Ingeborg Sundsvalen; Torkildsen, Øivind; Holmøy, Trygve; Berge, Tone; Myhr, Kjell-Morten; Harbo, Hanne-Cathrin Flinstad; Andersen, Jan Terje; Munthe, Ludvig Andre; Søraas, Arne Vasli; Celius, Elisabeth Gulowsen; Vaage, John T.; Lund-Johansen, Fridtjof; Nygaard, Gro Owren (Journal article; Peer reviewed, 2021)
      Introduction The effect of disease-modifying therapies (DMT) on vaccine responses is largely unknown. Understanding the development of protective immunity is of paramount importance to fight the COVID-19 pandemic. Objective ...

    • Humoral response to Epstein-Barr virus in patients with multiple sclerosis treated with B cell depletion therapy 

      Rød, Brit Ellen; Wergeland, Stig; Bjørnevik, Kjetil Lauvland; Holmøy, Trygve; Ulvestad, Elling; Njølstad, Gro; Myhr, Kjell-Morten; Torkildsen, Øivind (Journal article; Peer reviewed, 2023)
      Background B cell depletion therapy is highly effective in relapsing-remitting multiple sclerosis (RRMS). However, the precise underlying mechanisms of action for its biological effects in MS have still not been clarified. ...

    • Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity 

      Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Myhr, Kjell-Morten; Michelsen, Annika; Aukrust, Pål; Ueland, Thor (Peer reviewed; Journal article, 2013-09-19)
      Background. Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore the ...

    • Level of education and multiple sclerosis risk after adjustment for known risk factors: The EnvIMS study 

      Bjørnevik, Kjetil Lauvland; Riise, Trond; Cortese, Marianna; Holmøy, Trygve; Kampman, Margitta Theodora; Magalhaes, Sandra; Myhr, Kjell-Morten; Wolfson, Christina; Pugliatti, Maura (Peer reviewed; Journal article, 2015-05-26)
      Background: Several recent studies have found a higher risk of multiple sclerosis (MS) among people with a low level of education. This has been suggested to reflect an effect of smoking and lower vitamin D status in the ...

    • Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis 

      Wesnes, Kristin; Myhr, Kjell-Morten; Riise, Trond; Stokke, Silje Agnethe; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Bjørnevik, Kjetil Lauvland (Journal article; Peer reviewed, 2021)
      Background: Low vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. ...

    • Month of birth and risk of multiple sclerosis: confoundingand adjustments 

      Torkildsen, Øivind Fredvik; Aarseth, Jan Harald; Benjaminsen, Espen; Celius, Elisabeth Gulowsen; Holmøy, Trygve; Kampman, Margitta Theodora; Løken-Amsrud, Kristin Ingeleiv; Midgard, Rune; Myhr, Kjell-Morten; Riise, Trond; Torkildsen, Nina Agnethe Grytten (Peer reviewed; Journal article, 2014-02)
      A month of birth effect on multiple sclerosis (MS) risk has been reported from different countries. Recent critics have suggested that this finding is caused by confounding and that adequately adjusting for year and place ...

    • Mortality trends of amyotrophic lateral sclerosis in Norway 1951–2014: an age–period–cohort study 

      Nakken, Ola; Lindstrøm, Jonas Christoffer; Tysnes, Ole-Bjørn; Holmøy, Trygve (Peer reviewed; Journal article, 2016-12)
      Recent studies suggest that the incidence and mortality of amyotrophic lateral sclerosis (ALS) are increasing. Changing environmental factors could influence disease risk differently throughout life span, and also between ...

    • Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis 

      Røsjø, Egil Rørvik; Lindstrøm, Jonas Christoffer; Holmøy, Trygve; Myhr, Kjell-Morten; Varhaug, Kristin Nielsen; Torkildsen, Øivind Fredvik (Journal article; Peer reviewed, 2020-04-30)
      Background: High serum levels of 25-hydroxyvitamin D (25(OH)D) have been found among patients with a favorable disease course in relapsing-remitting MS (RRMS), indicating that this may limit clinical deterioration. Clinical ...

    • No association of tobacco use and disease activity in multiple sclerosis 

      Kvistad, Silje; Myhr, Kjell-Morten; Holmøy, Trygve; Saltyte Benth, Jurate; Løken-Amsrud, Kristin Ingeleiv; Wergeland, Stig; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Bakke, Søren Jacob; Torkildsen, Øivind (Peer reviewed; Journal article, 2016-08)
      Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally ...

    • Perinatal Depression and Anxiety in Women with Multiple Sclerosis: A Population-Based Cohort Study 

      Eid, Karine; Torkildsen, Øivind Fredvik Grytten; Aarseth, Jan Harald; Flemmen, Heidi Øyen; Holmøy, Trygve; Lorentzen, Åslaug Rudjord; Myhr, Kjell-Morten; Riise, Trond; Simonsen, Cecilia Smith; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Willumsen, Johannes Sverre; Øksendal, Nina; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)
      Objective: To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS). Methods: 114,629 pregnant women were included in the Norwegian Mother, Father and Child ...

    • Prevalence, Risk Factors, and Clinical and Biochemical Characteristics of Alemtuzumab-Induced Graves Disease 

      Ueland, Grethe Åstrøm; Ueland, Hans Olav; Stokland, Ann-Elin Meling; Bhan, Alok; Schønberg, Anne; Sollid, Stina Therese; Morgas, Dina Edvarda; Holmøy, Trygve; Lima, Kari; Methlie, Paal; Løvås, Kristian; Torkildsen, Øivind; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2024)
      Objective Atypical Graves disease (GD) is a common complication in multiple sclerosis (MS) patients treated with alemtuzumab. We present epidemiological, clinical, and biochemical characteristics of alemtuzumab-induced ...