• 2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia 

      Svendsen, Karianne; Krogh, Henriette Walaas; Igland, Jannicke; Tell, Grethe S.; Mundal, Liv J.; Holven, Kirsten Bjørklund; Bogsrud, Martin P.; Leren, Trond P.; Retterstøl, Kjetil (Journal article; Peer reviewed, 2021)
      Background and aims A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial ...
    • Association of low-density lipoprotein cholesterol with risk of aortic valve stenosis in familial hypercholesterolemia 

      Mundal, Liv; Hovland, Anders; Igland, Jannicke; Veierød, Marit Bragelien; Holven, Kirsten Bjørklund; Bogsrud, Martin Prøven; Tell, Grethe S.; Leren, Trond Paul; Retterstøl, Kjetil (Peer reviewed; Journal article, 2019)
      Importance: Aortic valve stenosis (AS) is the most common valve disease. Elevated levels of low-density lipoprotein (LDL) cholesterol are a risk factor; however, lipid-lowering treatment seems not to prevent progression ...
    • Impact of age on excess risk of coronary heart disease in patients with familial hypercholesterolaemia 

      Mundal, Liv; Igland, Jannicke; Veierød, Marit Bragelien; Holven, Kirsten Bjørklund; Ose, Leiv; Selmer, Randi; Wisløff, Torbjørn; Kristiansen, Ivar Sønbø; Tell, Grethe S.; Leren, Trond Paul; Retterstøl, Kjetil (Peer reviewed; Journal article, 2018)
      Objective: The primary objective was to study the risk of acute myocardial infarction (AMI) and coronary heart disease (CHD) in patients with familial hypercholesterolaemia (FH) and compare with the risk in the general ...
    • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Peer reviewed; Journal article, 2019-07-01)
      Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...
    • Lower risk of smoking-related cancer in individuals with familial hypercholesterolemia compared with controls: a prospective matched cohort study 

      Krogh, Henriette Walaas; Svendsen, Karianne; Igland, Jannicke; Mundal, Liv; Holven, Kirsten Bjørklund; Bogsrud, Martin Prøven; Leren, Trond Paul; Retterstøl, Kjetil (Peer reviewed; Journal article, 2019-12-17)
      According to guidelines, individuals with familial hypercholesterolemia (FH) shall receive lifestyle intervention and intensive lipid-lowering treatment from early in life to reduce the risk of coronary heart disease. Our ...
    • Risk of Ischemic Stroke and Total Cerebrovascular Disease in Familial Hypercholesterolemia. 

      Hovland, Anders; Mundal, Liv; Igland, Jannicke; Veierød, Marit Bragelien; Holven, Kirsten Bjørklund; Bogsrud, Martin Prøven; Tell, Grethe S.; Leren, Trond Paul; Retterstøl, Kjetil (Peer reviewed; Journal article, 2019-01)
      Background and Purpose—Familial hypercholesterolemia (FH) is a common autosomal dominant disease leading to increased level of serum LDL (low-density lipoprotein) cholesterol and risk of coronary heart disease. Whether FH ...
    • Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study 

      Ulven, Stine Marie; Christensen, Jacob J.; Nygård, Ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Lysne, Vegard; Laupsa-Borge, Johnny; Ueland, Per Magne; Midttun, Øivind; Meyer, Klaus; McCann, Adrian; Andersen, Lene Frost; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2019-04-26)
      Background: Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, ...