Browsing Bergen Open Research Archive by Author "Johannessen, Anne Christine"
Now showing items 1-20 of 39
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Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival
Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ... -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients
Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Ahmed, Israa A.H.; Elsheikh, Mariam; Dongre, Harsh Nitin; Jacobsen, Martha Rolland; Mohamed, Nazar; Fromreide, Siren; Suleiman, Ahmed Mohamed; Johannessen, Anne Christine; Nginamau, Elisabeth Sivy; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Background Tumor immune infiltrate has been explored in oral squamous cell carcinoma (OSCC), but studies on simultaneous characterization of multiple immune cell subtypes separately in stromal and intraepithelial tumor ... -
Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan
Suliman, Nada M.; Åstrøm, Anne Nordrehaug; Ali, Raouf Wahab; Salman, Hussein; Johannessen, Anne Christine (Peer reviewed; Journal article, 2013-11-21)Background: Pemphigus is a rare group of life-threatening mucocutaneous autoimmune blistering diseases. Frequently, oral lesions precede the cutaneous ones. This study aimed to describe clinical and histological features ... -
Combined in situ hybridization and immunohistochemistry on archival tissues reveals stromal microRNA-204 as prognostic biomarker for oral squamous cell carcinoma
Rajthala, Saroj; Dongre, Harsh; Parajuli, Himalaya; Min, Anjie; Nginamau, Elisabeth Sivy; Kvalheim, Arild; Lybak, Stein; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Micro-RNAs (miRs) are emerging as important players in carcinogenesis. Their stromal expression has been less investigated in part due to lack of methods to accurately differentiate between tumor compartments. This study ... -
A Comparison of p53 Isoform Profiles and Apoptosis Induced by Camptothecin or a Herbal Khat Extract (Catha Edulis (Vahl) Forssk. ex Endl.) in Leukemic Cell Lines: Exploring Cellular Responses in Therapy Development
Onyango, Therese Bredholt; Hjelle, Sigrun Margrethe; Haaland, Ingvild; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)Khat (Catha edulis (Vahl) Forssk. ex Endl.) is habitually used as a natural stimulant by millions of people, but is associated with adverse effects on gastrointestinal, cardiovascular and central neural systems. At the ... -
The composition of gingival inflammatory cell infiltrates in children studied by enzyme histochemistry
Alcoforado, Gil Alves Pessanha; Kristoffersen, Tore; Johannessen, Anne Christine; Nilsen, Rune (Journal article, 1990-07)Gingival biopsies were obtained from 23 children, aged 5-11 years (8.6 ± 1.8 years). Specimens were taken from areas of the gingiva adjacent to the teeth which were to be extracted because of caries or its sequelae and ... -
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, André; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-11)Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is ... -
Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction
Das, Ridhima; Harper, Lisa; Kitajima, Kayoko; Osman, Tarig Al-Hadi; Cimpan, Mihaela-Roxana; Johannessen, Anne Christine; Suliman, Salwa; Mackenzie, Ian C.; Costea, Daniela Elena (Journal article; Peer reviewed, 2023)We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell line ... -
Epithelial PD-L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan
Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Elsheikh, Mariam; Alhaj Ahmed, Israa Abdul Rhman Hassaballah; Dongre, Harsh Nitin; Fromreide, Siren; Suleiman, Ahmed M.; Johannessen, Anne Christine; Nginamau, Elisabeth Sivy; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Background We recently described the tumor immune microenvironment (TIME) in oral squamous cell carcinomas (OSCC) from Sudan by assessing the core of the lesions. However, the invasive tumor front (ITF) is the most active ... -
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ... -
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential
Dongre, Harsh; Rana, Neha; Fromreide, Siren; Rajthala, Saroj; Engelsen, Ingeborg Bøe; Paradis, Justine; Gutkind, J. Silvio; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Bjørge, Line; Costea, Daniela Elena (Journal article; Peer reviewed, 2020)Vulvar squamous cell carcinoma associated with lichen sclerosus (VLS-VSCC) are rare tumors but with higher recurrence and worse prognosis than other types of VSCC. Lack of experimental models has limited the search for ... -
Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinomas
Ibrahim, Salah Osman; Lillehaug, Johan; Johannessen, Anne Christine; Liavaag, P. G.; Nilsen, Rune; Vasstrand, Endre N. (Peer reviewed; Journal article, 1999)Using immunohistochemistry, expression of p53, transforming growth factor-alpha (TGF-α), epidermal growth factor receptor (EGFR), c-erbB-2/neu and proliferating cell nuclear antigen (PCNA) was examined in 26 fresh frozen ... -
Feasibility of a portable electronic nose for detection of oral squamous cell carcinoma in sudan
Mohamed, Nazar; van de Goor, Rens; El-Sheikh, Mariam; Elrayah, Osman; Osman, Tarig; Nginamau, Elisabeth Sivy; Johannessen, Anne Christine; Suleiman, Ahmed; Costea, Daniela Elena; Kross, Kenneth W. (Journal article; Peer reviewed, 2021-05-03)Background: Oral squamous cell carcinoma (OSCC) is increasing at an alarming rate particularly in low-income countries. This urges for research into noninvasive, user-friendly diagnostic tools that can be used in ... -
Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?
Steigen, Sonja E; Søland, Tine Merete; Nginamau, Elisabeth Sivy; Laurvik, Helene; Costea, Daniela-Elena; Johannessen, Anne Christine; Jebsen, Peter Wilhelm; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Peer reviewed; Journal article, 2020)Background: Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring ... -
Granulocyte macrophage-colony stimulating factor and keratinocyte growth factor control of early stages of differentiation of oral epithelium
Das, Ridhima; Virlan, Maria Justina Roxana; Xenaki, Victoria; Kulasekara, Keerthi Kumara; Lukandu, Ochiba Mohammed; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Calenic, Bogdan; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Oral epithelial differentiation is known to be directed by underlying fibroblasts, but the responsible factor(s) have not been identified. We aimed here to identify fibroblast-derived factors responsible for oral epithelial ... -
Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients
Pandey, Sushma; Follin-Arbelet, Benoit; Bahadur Pun, Chin; K. Gautam, Dej; Johannessen, Anne Christine; Petersen, Fernanda Cristina; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Peer reviewed, 2020)Helicobacter pylori (HP) infection is an established causative agent for gastric cancer. Although the oral cavity is a part of the gastrointestinal system, the presence and possible causative role of HP in oral squamous ... -
Immunohistochemical detection of p53 in non-malignant and malignant oral lesions associated with snuff dipping in the Sudan and Sweden
Ibrahim, Salah Osman; Johannessen, Anne Christine; Idris, Ali M.; Hirsch, Jan M.; Vasstrand, Endre N.; Magnusson, Bengt; Nilsen, Rune (Journal article, 1996)Immunohistochemistry was used to examine the expression of p53 in pre-malignant oral lesions and oral squamous-cell carcinomas (SCCs) from Swedish and Sudanese snuff-dippers, as well as in pre-malignant oral lesions and ... -
In vitro reconstruction of human junctional and sulcular epithelium
Dabija-Wolter, Gabriela; Bakken, Vidar; Cimpan, Mihaela R.; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article, 2012)Background: The aim of this study was to develop and characterize standardized in vitro three-dimensional organotypic models of human junctional epithelium (JE) and sulcular epithelium (SE). Methods Organotypic models were ... -
Inflammatory tissue reactions around aseptically loose cemented hip prostheses: A retrieval study of the Spectron EF stem with Reflection All-Poly acetabular cup
Wolf, Susann; Johannessen, Anne Christine; Ellison, Peter; Furnes, Ove Nord; Hallan, Geir; Rogg, Katharina; Skarstein, Kathrine; Høl, Paul Johan (Journal article; Peer reviewed, 2022)The cemented Spectron EF stem in combination with the cemented non-crosslinked Reflection All-Poly cup showed a high rate of mid-term aseptic loosening. However, the failure mechanisms are not fully known. We assessed the ...