Browsing Bergen Open Research Archive by Author "Johnsen, Erik"
Now showing items 1-20 of 22
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Anti-depressive effectiveness of olanzapine, quetiapine, risperidone and ziprasidone: a pragmatic, randomized trial
Kjelby, Eirik; Jørgensen, Hugo A.; Kroken, Rune A.; Løberg, Else-Marie; Johnsen, Erik (Peer reviewed; Journal article, 2011-08-31)Background: Efficacy studies indicate anti-depressive effects of at least some second generation antipsychotics (SGAs). The Bergen Psychosis Project (BPP) is a 24-month, pragmatic, industry-independent, randomized, head-tohead ... -
Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study
Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ... -
The cannabis pathway to non-affective psychosis may reflect less neurobiological vulnerability
Løberg, Else-Marie; Helle, Siri; Nygård, Merethe; Berle, Jan Øystein; Kroken, Rune; Johnsen, Erik (Peer reviewed; Journal article, 2014-11-18)There is a high prevalence of cannabis use reported in non-affective psychosis. Early prospective longitudinal studies conclude that cannabis use is a risk factor for psychosis, and neurochemical studies on cannabis have ... -
Cognitive changes in patients with acute phase psychosis - Effects of illicit drug use
Helle, Siri; Gjestad, Rolf; Johnsen, Erik; Kroken, Rune; Jørgensen, Hugo A.; Løberg, Else-Marie (Peer reviewed; Journal article, 2014-12)Illicit drug use may influence cognition in non-affective psychosis. Previous studies have shown better cognition in psychosis with illicit drug use as compared to psychosis only. Possibly, illicit drug using patients have ... -
Cognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated norms
Anda-Ågotnes, Liss Gøril; Brønnick, Kolbjørn Kallesten; Johannessen, Jan Olav; Joa, Inge; Kroken, Rune Andreas; Johnsen, Erik; Rettenbacher, Maria; Fathian, Farivar; Løberg, Else-Marie (Peer reviewed; Journal article, 2019-10-01)Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized ... -
Constructing the immune signature of schizophrenia for clinical use and research; an integrative review translating descriptives into diagnostics
Kroken, Rune Andreas; Sommer, Iris Else Clara; Steen, Vidar Martin; Dieset, Ingrid; Johnsen, Erik (Peer reviewed; Journal article, 2019)Schizophrenia is considered a syndrome comprised by several disease phenotypes, covering a range of underlying pathologies. One of these disease mechanisms seems to involve immune dysregulation and neuroinflammation. While ... -
A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation
Kroken, Rune; Løberg, Else-Marie; Drønen, Tore; Grüner, Renate; Hugdahl, Kenneth; Kompus, Kristiina; Skrede, Silje; Johnsen, Erik (Peer reviewed; Journal article, 2014-02-04)Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic ... -
Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders.
Mørkved, Nina; Johnsen, Erik; Kroken, Rune Andreas; Gjestad, Rolf; Winje, Dagfinn; Thimm, J.; Fathian, Farivar; Rettenbacher, Maria; Anda-Ågotnes, Liss Gøril; Løberg, Else-Marie (Journal article; Peer reviewed, 2020)Childhood trauma (CT) is a risk factor for schizophrenia spectrum disorders (SSDs), and cognitive impairment is a core feature and a vulnerability marker of SSDs. Studies of the relationship between CT and cognitive ... -
Dynamic Functional Connectivity Patterns in Schizophrenia and the Relationship With Hallucinations
Weber, Sarah; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)There is a wealth of evidence showing aberrant functional connectivity (FC) in schizophrenia but with considerable variability in findings across studies. Dynamic FC is an extension of traditional static FC, in that such ... -
Effectiveness of second generation antipsychotics: A systematic review of randomized trials
Johnsen, Erik; Jørgensen, Hugo A. (Peer reviewed; Journal article, 2008-04-25)Background Systematic reviews based on efficacy trials are inconclusive about which second generation antipsychotic drug (SGA) should be preferred in normal clinical practice, and studies with longer duration and more ... -
Effectiveness of second-generation antipsychotics: a naturalistic, randomized comparison of olanzapine, quetiapine, risperidone, and ziprasidone
Johnsen, Erik; Kroken, Rune A.; Wentzel-Larsen, Tore; Jørgensen, Hugo A. (Peer reviewed; Journal article, 2010-03-24)Background: No clear recommendations exist regarding which antipsychotic drug should be prescribed first for a patient suffering from psychosis. The primary aims of this naturalistic study were to assess the head-to-head ... -
Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis
Sinkeviciute, Igne; Begemann, Marieke; Prikken, Merel; Oranje, Bob; Johnsen, Erik; Lei, Wan U.; Hugdahl, Kenneth; Kroken, Rune Andreas; Rau, Carina; Jacobs, Jolien D.; Mattaroccia, Silvia; Sommer, Iris Else Clara (Peer reviewed; Journal article, 2018)Cognitive impairment is a core feature of schizophrenia, which is predictive for functional outcomes and is, therefore, a treatment target in itself. Yet, literature on efficacy of different pharmaco-therapeutic options ... -
Elderly Patients With No Previous Psychiatric History: Suicidality and Other Factors Relating to Psychiatric Acute Admissions
Lund-Heimark, Hallvard; Kjelby, Eirik; Mehlum, Lars; Gjestad, Rolf; Selbæk, Geir; Kroken, Rune Andreas; Johnsen, Erik; Ødegaard, Ketil Joachim; Mellesdal, Liv Solrunn (Journal article; Peer reviewed, 2020)Background: The common recommendation that adults with onset of mental illness after the age of 65 should receive specialised psychogeriatric treatment is based on limited evidence. Aims: To compare factors related to ... -
Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study
Falkenberg, Liv E.; Westerhausen, René; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Kompus, Kristiina; Ersland, Lars; Sandøy, Lydia Brunvoll; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)The arcuate fasciculus (AF) has been implicated in the pathology behind schizophrenia and auditory verbal hallucinations (AVHs). White matter tracts forming the arcuate fasciculus can be quantified and visualized using ... -
Hallucinations in acutely admitted patients with psychosis, and effectiveness of risperidone, olanzapine, quetiapine, and ziprasidone: a pragmatic, randomized study
Johnsen, Erik; Sinkeviciute, Igne; Løberg, Else-Marie; Kroken, Rune A.; Hugdahl, Kenneth; Jørgensen, Hugo A. (Peer reviewed; Journal article, 2013-09-30)Background Hallucinations are prevalent in schizophrenia and related psychotic disorders and may have severe consequences for the affected patients. Antipsychotic drug trials that specifically address the anti-hallucinatory ... -
Intra-Regional Glu-GABA vs Inter-Regional Glu-Glu Imbalance: A 1H-MRS Study of the Neurochemistry of Auditory Verbal Hallucinations in Schizophrenia.
Hjelmervik, Helene; Craig-Craven, Alexander Richard; Sinkeviciute, Igne; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Gruner, Eli Renate; Hugdahl, Kenneth (Peer reviewed; Journal article, 2019-10-18)Glutamate (Glu), gamma amino-butyric acid (GABA), and excitatory/inhibitory (E/I) imbalance have inconsistently been implicated in the etiology of schizophrenia. Elevated Glu levels in language regions have been suggested ... -
Mapping psychotic-like experiences: Results from an online survey
Kusztrits, Isabella; Larøi, Frank; Laloyaux, Julien Freddy; Marquardt, Lynn Anne; Sinkeviciute, Igne; Kjelby, Eirik; Johnsen, Erik; Sommer, Iris Else Clara; Hugdahl, Kenneth; Hirnstein, Marco (Journal article; Peer reviewed, 2020-10-02)Suggestions have been made that psychotic‐like experiences (PLEs), such as hallucinatory and delusional experiences, exist on a continuum from healthy individuals to patients with a diagnosis of schizophrenia. We used the ... -
One-year outcome and adherence to pharmacological guidelines in first-episode schizophrenia: Results from a consecutive cohort study
Drosos, Petros; Brønnick, Kolbjørn Kallesten; Joa, Inge; Johannessen, Jan Olav; Johnsen, Erik; Kroken, Rune Andreas; Stain, Helen J.; Hegelstad, Wenche; Larsen, Tor Ketil (Journal article; Peer reviewed, 2020)Background Remission in schizophrenia is difficult to achieve. Antipsychotic drugs are critical in the treatment of schizophrenia. International guidelines for the pharmacological treatment of schizophrenia recommend a ... -
The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations
Kompus, Kristiina; Falkenberg, Liv Eggset; Bless, Josef J; Johnsen, Erik; Kroken, Rune; Kråkvik, Bodil; Larøi, Frank; Løberg, Else-Marie; Vedul-Kjelsås, Einar; Westerhausen, René; Hugdahl, Kenneth (Peer reviewed; Journal article, 2013-04-24)Auditory verbal hallucinations (AVHs) are a subjective experience of “hearing voices” in the absence of corresponding physical stimulation in the environment. The most remarkable feature of AVHs is their perceptual quality, ... -
The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis
Johnsen, Erik; Fathian, Farivar; Kroken, Rune A; Steen, Vidar M; Jørgensen, Hugo A; Gjestad, Rolf; Løberg, Else-Marie (Peer reviewed; Journal article, 2016-03-14)Background Inflammatory processes have been implicated in the etiology of schizophrenia and related psychoses, in which cognitive deficits represent core symptoms. The aim of the present study was to investigate possible ...