Browsing Bergen Open Research Archive by Author "Jugessur, Astanand"
Now showing items 1-20 of 22
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Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with DMD, FGF13, EGFL6, and Additional Loci at Xp22.2
Skare, Øivind; Lie, Rolv T.; Haaland, Øystein Ariansen; Gjerdevik, Miriam; Romanowska, Julia; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-22)Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which ... -
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ... -
Design efficiency in genetic association studies
Gjerdevik, Miriam; Gjessing, Håkon K.; Romanowska, Julia; Haaland, Øystein Ariansen; Jugessur, Astanand; Czajkowski, Nikolai Olavi; Lie, Rolv T. (Journal article; Peer reviewed, 2020)Selecting the best design for genetic association studies requires careful deliberation; different study designs can be used to scan for different genetic effects, and each design has its own set of strengths and limitations. ... -
Detecting diferentially methylated regions using a fast wavelet‑based approach to functional association analysis
Denault, William Robert Paul; Jugessur, Astanand (Journal article; Peer reviewed, 2021)Background We present here a computational shortcut to improve a powerful wavelet-based method by Shim and Stephens (Ann Appl Stat 9(2):665–686, 2015. https://doi.org/10.1214/14-AOAS776) called WaveQTL that was originally ... -
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies
Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ... -
Epigenome-wide association study of leukocyte telomere length
Lee, Yunsung; Sun, Dianjianyi; Ori, Anil P.S.; Lu, Ake T.; Seeboth, Anne; Harris, Sarah E.; Deary, Ian J.; Marioni, Riccardo E.; Sørensen, Mette; Mengel-From, Jonas; Hjelmborg, Jacob; Christensen, Kaare; Wilson, James G.; Levy, Daniel; Reiner, Alex P.; Chen, Wei; Li, Shengxu; Harris, Jennifer Ruth; Magnus, Per; Aviv, Abraham; Jugessur, Astanand; Horvath, Steve (Peer reviewed; Journal article, 2019)Telomere length is associated with age-related diseases and is highly heritable. It is unclear, however, to what extent epigenetic modifications are associated with leukocyte telomere length (LTL). In this study, we conducted ... -
A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population
Denault, William Robert Paul; Romanowska, Julia; Helgeland, Øyvind; Jacobsson, Bo; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)Background Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW has increased dramatically since ... -
Gene-methylation interactions: Discovering region-wise DNA methylation levels that modify SNP-associated disease risk
Romanowska, Julia; Haaland, Øystein Ariansen; Jugessur, Astanand; Gjerdevik, Miriam; Xu, Zongli; Taylor, Jack A.; Wilcox, Allen J; Jonassen, Inge; Lie, Rolv T.; Gjessing, Håkon K. (Journal article; Peer reviewed, 2020)Background Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously. ... -
Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios
Haaland, Øystein Ariansen; Jugessur, Astanand; Gjerdevik, Miriam; Romanowska, Julia; Shi, Min; Beaty, Terri H.; Marazita, Mary L.; Murray, Jeffrey C.; Wilcox, Allen J.; Lie, Rolv T.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2017-09-12)Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease ... -
A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption
Haaland, Øystein Ariansen; Romanowska, Julia; Gjerdevik, Miriam; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article, 2019-06-24)Background: Although both genetic and environmental factors have been reported to influence the risk of isolated cleft lip with or without cleft palate (CL/P), the exact mechanisms behind CL/P are still largely unaccounted ... -
A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption
Haaland, Øystein Ariansen; Romanowska, Julia; Gjerdevik, Miriam; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2019-06-24)Background: Although both genetic and environmental factors have been reported to influence the risk of isolated cleft lip with or without cleft palate (CL/P), the exact mechanisms behind CL/P are still largely unaccounted ... -
A genome-wide search for gene-environment effects in isolated cleft lip with or without cleft palate triads points to an interaction between maternal periconceptional vitamin use and variants in ESRRG
Haaland, Øystein Ariansen; Lie, Rolv T.; Romanowska, Julia; Gjerdevik, Miriam; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-26)Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these ... -
Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls
Gjerdevik, Miriam; Jugessur, Astanand; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Cordell, Heather J.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2019-04-02)Background: Log-linear and multinomial modeling offer a flexible framework for genetic association analyses of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety of child-parent ... -
Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data
Vefring, Hege K.; Wee, Line; Jugessur, Astanand; Gjessing, Håkon K.; Nilsen, Stein Tore; Lie, Rolv Terje (Peer reviewed; Journal article, 2010-06-10)Background Preeclampsia is a debilitating disorder affecting approximately 3% of pregnant women in the Western world. Although inconclusive, current evidence suggests that the renin-angiotensin system may be involved in ... -
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia
Jugessur, Astanand; Shi, Min; Gjessing, Håkon K.; Lie, Rolv Terje; Wilcox, Allen James; Weinberg, Clarice Ring; Christensen, Kaare; Boyles, Abee Lowman; Daack-Hirsch, Sandra; Nguyen, Truc Trung; Christiansen, Lene; Lidral, Andrew Carl; Murray, Jeffrey Clark (Peer reviewed; Journal article, 2010-07-09)Background Fetal conditions can in principle be affected by the mother's genotype working through the prenatal environment. Methodology/Principal Findings Genotypes for 1536 SNPs in 357 cleft candidate genes were available ... -
Matrilineal diversity and population history of Norwegians
Kristjansson, Dana; Bohlin, Jon; Jugessur, Astanand; Schurr, Theodore G. (Journal article; Peer reviewed, 2021)Background While well known for its Viking past, Norway's population history and the influences that have shaped its genetic diversity are less well understood. This is particularly true with respect to its demography, ... -
A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts
Skare, Øivind; Gjessing, Håkon K.; Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand (Peer reviewed; Journal article, 2017-09-06)Background: GWAS discoveries on the X-chromosome are underrepresented in the literature primarily because the analytical tools that have been applied were originally designed for autosomal markers. Our objective here is ... -
Parent-of-origin-environment interactions in case-parent triads with or without independent controls
Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand; Gjessing, Håkon K. (Peer reviewed; Journal article, 2018-03)With case–parent triad data, one can frequently deduce parent of origin of the child's alleles. This allows a parent‐of‐origin (PoO) effect to be estimated as the ratio of relative risks associated with the alleles inherited ... -
Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels
Lee, Yunsung; Choufani, Sanaa; Weksberg, Rosanna; Wilson, Samantha L.; Yuan, Victor; Burt, Amber; Marsit, Carmen; Lu, Ake T.; Ritz, Beate; Bohlin, Jon; Gjessing, Håkon K.; Harris, Jennifer Ruth; Magnus, Per; Binder, Alexandra M.; Robinson, Wendy P.; Jugessur, Astanand; Horvath, Steve (Peer reviewed; Journal article, 2019)The human pan-tissue epigenetic clock is widely used for estimating age across the entire lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental DNAm methylation (DNAm) data. We ... -
Rapid genotyping of the human renin (REN) gene by the LightCycler® instrument: Identification of unexpected nucleotide substitutions within the selected hybridization probe area
Wee, Line L.; Vefring, Hege; Jonsson, Grete; Jugessur, Astanand; Lie, Rolv Terje (Peer reviewed; Journal article, 2010)Preeclampsia is a serious disorder affecting nearly 3% of all in the Western world. It is associated with hypertension and proteinuria, and several lines of evidence suggest that the renin-angiotensin system (RAS) may be ...