Blar i Bergen Open Research Archive på forfatter "Jul-Larsen, Åsne"
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Immune Responses in Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the 2009 Influenza Pandemic in Norway
Mohn, Kristin Greve-Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M; Mjaaland, Siri (Peer reviewed; Journal article, 2015-11-25)Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during ... -
Live attenuated influenza vaccine in children induces b-cell responses in tonsils
Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Pathirana, Rishi; Bredholt, Geir; Jul-Larsen, Åsne; Trieu, Mai Chi; Jalloh, Sarah Larteley Lartey; Montemoli, Emanuele; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016)Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ... -
Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response
Madsen, Anders; Jul-Larsen, Åsne; Trieu, Mai Chi; Krammer, Florian; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)Current influenza vaccines have a suboptimal effectiveness. The introduction of a novel A/H1N1 influenza virus in 2009 (H1N1pdm09) provided a unique opportunity to study the humoral response to the AS03-adjuvanted H1N1pdm09 ... -
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
Grudic, Amra; Jul-Larsen, Åsne; Haring, SJ; Wold, MS; Lønning, Per Eystein; Bjerkvig, Rolf; Bøe, Stig Ove (Peer reviewed; Journal article, 2007-10-24)The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5–15%) employs a recombination-based mechanism ... -
Single dose vaccination of the ASO3-adjuvanted A (H1N1)pdm09 monovalent vaccine in health care workers elicits homologous and cross-reactive cellular and humoral responses to H1N1 strains
Jalloh, Sarah Larteley Lartey; Pathirana, Rishi; Zhou, Fan; Jul-Larsen, Åsne; Montomoli, Emanuele; Wood, John; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015)Healthcare workers (HCW) were prioritized for vaccination during the 2009 influenza A(H1N1)pdm09 pandemic. We conducted a clinical trial in October 2009 where 237 HCWs were immunized with a AS03-adjuvanted A(H1N1)pdm09 ... -
Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein
Jul-Larsen, Åsne; Grudic, Amra; Bjerkvig, Rolf; Bøe, Stig O. (Peer reviewed; Journal article, 2010-11-21)Background The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is ...