Blar i Bergen Open Research Archive på forfatter "Karlsson, Thomas"
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Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation
Karlsson, Thomas; Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Pollock, Pamela M.; Salvesen, Helga; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2017-12-16)PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β ... -
Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells
Mazloumi Gavgani, Fatemeh; Karlsson, Thomas; Tangen, Ingvild Løberg; Papdine Morovicz, Andrea; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; Spang, Katharina Maria; Krakstad, Camilla; Guillermet-Guibert, Julie; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α and p110β are ubiquitously expressed but differently targeted in tumours. In cancer, PIK3CB (encoding p110β) is seldom mutated compared with PIK3CA ... -
A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction
Karlsson, Thomas; Altankhuyag, Altanchimeg; Dobrovolska, Olena; Turcu, Diana Cornelia; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07)Polyphosphoinositides (PPIns) are present in the nucleus where they participate in crucial nuclear processes, such as chromatin remodelling, transcription and mRNA processing. In a previous interactomics study, aimed to ...