• Akathisia and atypical antipsychotics. Relation to suicidality, agitation and depression in a clinical trial 

      Bjarke, Jill Kristin; Gjerde, Helga Nødland; Jørgensen, Hugo A; Kroken, Rune Andreas; Løberg, Else-Marie; Johnsen, Erik (Journal article; Peer reviewed, 2022)
      Objective: Akathisia is among the most unpleasant side effects related to antipsychotic drug (AP) use, and possible associations between akathisia and agitation, depression and suicidal behaviour, respectively, have been ...
    • Association between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute psychosis 

      Fathian, Farivar; Gjestad, Rolf; Kroken, Rune Andreas; Løberg, Else-Marie; Reitan, Solveig Merete Klæbo; Fleichhacker, W. Wolfgang; Rettenbacher, Maria; Larsen, Tor Ketil; Joa, Inge; Stabell, Lena Antonsen; Kjelby, Eirik; Sinkevicute, Igne; Alisauskiene, Renata; Steen, Vidar Martin; Johnsen, Erik (Journal article; Peer reviewed, 2022)
      Background A potential role of inflammatory pathways in the pathology of schizophrenia has been suggested for at least a subgroup of patients. Elevated levels of the inflammatory marker C-reactive protein (CRP) have been ...
    • The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study 

      Larsen, Jeanette Brun; Reitan, Solveig Merete Klæbo; Løberg, Else-Marie; Rettenbacher, Maria; Bruserud, Øystein; Larsen, Tor Ketil; Anda, Liss Gøril; Bartz-Johannessen, Christoffer; Johnsen, Erik; Kroken, Rune Andreas (Journal article, 2021)
      Background In schizophrenia, impaired psychomotor speed is a common symptom predicting worse functional outcome. Inflammation causes changes in white matter integrity, which may lead to reduced psychomotor speed. Therefore, ...
    • Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study 

      Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)
      Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ...
    • Cognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated norms 

      Anda-Ågotnes, Liss Gøril; Brønnick, Kolbjørn Kallesten; Johannessen, Jan Olav; Joa, Inge; Kroken, Rune Andreas; Johnsen, Erik; Rettenbacher, Maria; Fathian, Farivar; Løberg, Else-Marie (Peer reviewed; Journal article, 2019-10-01)
      Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized ...
    • Constructing the immune signature of schizophrenia for clinical use and research; an integrative review translating descriptives into diagnostics 

      Kroken, Rune Andreas; Sommer, Iris Else Clara; Steen, Vidar Martin; Dieset, Ingrid; Johnsen, Erik (Peer reviewed; Journal article, 2019)
      Schizophrenia is considered a syndrome comprised by several disease phenotypes, covering a range of underlying pathologies. One of these disease mechanisms seems to involve immune dysregulation and neuroinflammation. While ...
    • Differential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trial 

      Sinkeviciute, Igne; Hugdahl, Kenneth Jan; Bartz-Johannessen, Christoffer; Kroken, Rune Andreas; Løberg, Else-Marie; Kjelby, Eirik; Rettenbacher, maria; Joa, Inge; Reitan, Solveig Merete Klæbo; Alisauskiene, Renata; Fathian, Farivar; Johnsen, Erik (Journal article; Peer reviewed, 2021-07)
      Background Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in ...
    • Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders. 

      Mørkved, Nina; Johnsen, Erik; Kroken, Rune Andreas; Gjestad, Rolf; Winje, Dagfinn; Thimm, J.; Fathian, Farivar; Rettenbacher, Maria; Anda-Ågotnes, Liss Gøril; Løberg, Else-Marie (Journal article; Peer reviewed, 2020)
      Childhood trauma (CT) is a risk factor for schizophrenia spectrum disorders (SSDs), and cognitive impairment is a core feature and a vulnerability marker of SSDs. Studies of the relationship between CT and cognitive ...
    • Dynamic Functional Connectivity Patterns in Schizophrenia and the Relationship With Hallucinations 

      Weber, Sarah; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      There is a wealth of evidence showing aberrant functional connectivity (FC) in schizophrenia but with considerable variability in findings across studies. Dynamic FC is an extension of traditional static FC, in that such ...
    • Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis 

      Sinkeviciute, Igne; Begemann, Marieke; Prikken, Merel; Oranje, Bob; Johnsen, Erik; Lei, Wan U.; Hugdahl, Kenneth; Kroken, Rune Andreas; Rau, Carina; Jacobs, Jolien D.; Mattaroccia, Silvia; Sommer, Iris Else Clara (Peer reviewed; Journal article, 2018)
      Cognitive impairment is a core feature of schizophrenia, which is predictive for functional outcomes and is, therefore, a treatment target in itself. Yet, literature on efficacy of different pharmaco-therapeutic options ...
    • Elderly Patients With No Previous Psychiatric History: Suicidality and Other Factors Relating to Psychiatric Acute Admissions 

      Lund-Heimark, Hallvard; Kjelby, Eirik; Mehlum, Lars; Gjestad, Rolf; Selbæk, Geir; Kroken, Rune Andreas; Johnsen, Erik; Ødegaard, Ketil Joachim; Mellesdal, Liv Solrunn (Journal article; Peer reviewed, 2020)
      Background: The common recommendation that adults with onset of mental illness after the age of 65 should receive specialised psychogeriatric treatment is based on limited evidence. Aims: To compare factors related to ...
    • Glutamate- and GABA-Modulated Connectivity in Auditory Hallucinations—A Combined Resting State fMRI and MR Spectroscopy Study 

      Weber, Sarah; Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2021)
      Background: Auditory verbal hallucinations (AVH) have been linked to aberrant interhemispheric connectivity between the left and the right superior temporal gyrus (STG), labeled the interhemispheric miscommunication theory. ...
    • Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study 

      Falkenberg, Liv E.; Westerhausen, René; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Kompus, Kristiina; Ersland, Lars; Sandøy, Lydia Brunvoll; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      The arcuate fasciculus (AF) has been implicated in the pathology behind schizophrenia and auditory verbal hallucinations (AVHs). White matter tracts forming the arcuate fasciculus can be quantified and visualized using ...
    • Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis 

      Skrede, Silje; Berg, Jon Andsnes; Fossan, Kjell Ove; Bartz-Johannessen, Christoffer; Løberg, Else-Marie; Kroken, Rune Andreas; Johnsen, Erik (Journal article, 2021)
      Background The prevalence of new psychoactive substances (NPS) in acute psychotic patients has not been investigated systematically. We applied a highly sensitive and specific mass spectrometry method for detection of NPS ...
    • Impact of childhood trauma on antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, semi-randomized trial 

      Mørkved, Nina; Johnsen, Erik; Kroken, Rune Andreas; Winje, Dagfinn; Larsen, Tor Ketil; Thimm, Jens; Rettenbacher, M.A.; Johannesen, C.A. Bartz; Løberg, Else-Marie (Journal article; Peer reviewed, 2022)
      Antipsychotic medications are generally effective in ameliorating psychotic symptoms in schizophrenia spectrum disorders (SSDs). Identifying predictors associated with poor treatment response is important for a personalized ...
    • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

      Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...
    • Intra-Regional Glu-GABA vs Inter-Regional Glu-Glu Imbalance: A 1H-MRS Study of the Neurochemistry of Auditory Verbal Hallucinations in Schizophrenia. 

      Hjelmervik, Helene; Craven, Alexander R.; Sinkeviciute, Igne; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Gruner, Eli Renate; Hugdahl, Kenneth (Peer reviewed; Journal article, 2019-10-18)
      Glutamate (Glu), gamma amino-butyric acid (GABA), and excitatory/inhibitory (E/I) imbalance have inconsistently been implicated in the etiology of schizophrenia. Elevated Glu levels in language regions have been suggested ...
    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Journal article; Peer reviewed, 2021)
      Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...
    • Mortality and non-use of antipsychotic drugs after acute admission in schizophrenia: A prospective total-cohort study 

      Strømme, Maria Fagerbakke; Mellesdal, Liv Solrunn; Bartz-Johannesen, Christoffer; Kroken, Rune Andreas; Krogenes, Marianne; Mehlum, Lars; Johnsen, Erik (Journal article; Peer reviewed, 2021)
      Background In society at large, it is debated whether use of antipsychotic drugs is associated with increased or decreased mortality among patients with schizophrenia. Large register studies have demonstrated an increased ...
    • Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients 

      Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Sinkeviciute, Igne; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Grüner, Eli Renate; Sommer, Iris E.; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2021)
      Objectives Negative emotional valence of auditory verbal hallucinations (AVHs) in schizophrenia can be a source of distress and is considered a strong predictor of illness severity. Previous studies have found glutamate ...