• Amphetamine-induced psychosis - a separate diagnostic entity or primary psychosis triggered in the vulnerable? 

      Bramness, Jørgen G.; Gundersen, Øystein H.; Guterstam, Joar; Rognli, Eline B.; Konstenius, Maija; Løberg, Else-Marie; Medhus, Sigrid; Tanum, Lars; Franck, Johan (Peer reviewed; Journal article, 2012-12-05)
      Use of amphetamine and methamphetamine is widespread in the general population and common among patients with psychiatric disorders. Amphetamines may induce symptoms of psychosis very similar to those of acute schizophrenia ...
    • Anti-depressive effectiveness of olanzapine, quetiapine, risperidone and ziprasidone: a pragmatic, randomized trial 

      Kjelby, Eirik; Jørgensen, Hugo A.; Kroken, Rune A.; Løberg, Else-Marie; Johnsen, Erik (Peer reviewed; Journal article, 2011-08-31)
      Background: Efficacy studies indicate anti-depressive effects of at least some second generation antipsychotics (SGAs). The Bergen Psychosis Project (BPP) is a 24-month, pragmatic, industry-independent, randomized, head-tohead ...
    • The association between lithium use and neurocognitive performance in patients with bipolar disorder 

      Burdick, Katherine E.; Millett, Caitlin E.; Russo, Manuela; Alda, Martin; Alliey-Rodriguez, Ney; Anand, Amit; Balaraman, Yokesh; Berrettini, Wade H.; Bertram, Holli; Calabrese, Joseph R.; Calkin, Cynthia V.; Conroy, Carla; Coryell, William; DeModena, Anna; Feeder, Scott; Fisher, Carrie; Frazier, Nicole; Frye, Mark; Gao, Keming; Garnham, Julie; Gershon, Elliot S.; Glazer, Kara; Goes, Fernando S.; Goto, Toyomi; Harrington, Gloria J.; Jakobsen, Petter; Kamali, Masoud; Kelly, Marisa; Leckband, Susan G.; Løberg, Else-Marie; Lohoff, Falk W.; Maihofer, Adam X.; McCarthy, Michael J.; McInnis, Melvin; Morken, Gunnar; Nievergelt, Caroline M.; Nurnberger, John I.; Oedegaard, Ketil J.; Ortiz, Abigail; Ritchey, Megan; Ryan, Kelly; Schinagle, Martha; Schwebel, Candice; Shaw, Martha; Shilling, Paul D.; Slaney, Claire; Stapp, Emma; Tarwater, Bruce; Zandi, Peter P.; Kelsoe, John R. (Journal article; Peer reviewed, 2020)
      Lithium remains the gold standard for the treatment of bipolar disorder (BD); however, its use has declined over the years mainly due to the side effects and the subjective experience of cognitive numbness reported by ...
    • Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study 

      Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)
      Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ...
    • The cannabis pathway to non-affective psychosis may reflect less neurobiological vulnerability 

      Løberg, Else-Marie; Helle, Siri; Nygård, Merethe; Berle, Jan Øystein; Kroken, Rune; Johnsen, Erik (Peer reviewed; Journal article, 2014-11-18)
      There is a high prevalence of cannabis use reported in non-affective psychosis. Early prospective longitudinal studies conclude that cannabis use is a risk factor for psychosis, and neurochemical studies on cannabis have ...
    • Cognitive changes in patients with acute phase psychosis - Effects of illicit drug use 

      Helle, Siri; Gjestad, Rolf; Johnsen, Erik; Kroken, Rune; Jørgensen, Hugo A.; Løberg, Else-Marie (Peer reviewed; Journal article, 2014-12)
      Illicit drug use may influence cognition in non-affective psychosis. Previous studies have shown better cognition in psychosis with illicit drug use as compared to psychosis only. Possibly, illicit drug using patients have ...
    • Cognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated norms 

      Anda-Ågotnes, Liss Gøril; Brønnick, Kolbjørn Kallesten; Johannessen, Jan Olav; Joa, Inge; Kroken, Rune Andreas; Johnsen, Erik; Rettenbacher, Maria; Fathian, Farivar; Løberg, Else-Marie (Peer reviewed; Journal article, 2019-10-01)
      Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized ...
    • A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation 

      Kroken, Rune; Løberg, Else-Marie; Drønen, Tore; Grüner, Renate; Hugdahl, Kenneth; Kompus, Kristiina; Skrede, Silje; Johnsen, Erik (Peer reviewed; Journal article, 2014-02-04)
      Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic ...
    • Does changing from a first generation antipsychotic (perphenazin) to a second generation antipsychotic (risperidone) alter brain activation and motor activity? A case report 

      Berle, Jan Øystein; Løberg, Else-Marie; Fasmer, Ole Bernt (Peer reviewed; Journal article, 2013-05-06)
      Background: In patients with schizophrenia, altered brain activation and motor activity levels are central features, reflecting cognitive impairments and negative symptoms, respectively. Newer studies using nonlinear methods ...
    • Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders. 

      Mørkved, Nina; Johnsen, Erik; Kroken, Rune Andreas; Gjestad, Rolf; Winje, Dagfinn; Thimm, J.; Fathian, Farivar; Rettenbacher, Maria; Anda-Ågotnes, Liss Gøril; Løberg, Else-Marie (Journal article; Peer reviewed, 2020)
      Childhood trauma (CT) is a risk factor for schizophrenia spectrum disorders (SSDs), and cognitive impairment is a core feature and a vulnerability marker of SSDs. Studies of the relationship between CT and cognitive ...
    • Dynamic Functional Connectivity Patterns in Schizophrenia and the Relationship With Hallucinations 

      Weber, Sarah; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      There is a wealth of evidence showing aberrant functional connectivity (FC) in schizophrenia but with considerable variability in findings across studies. Dynamic FC is an extension of traditional static FC, in that such ...
    • Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study 

      Falkenberg, Liv E.; Westerhausen, René; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Kompus, Kristiina; Ersland, Lars; Sandøy, Lydia Brunvoll; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      The arcuate fasciculus (AF) has been implicated in the pathology behind schizophrenia and auditory verbal hallucinations (AVHs). White matter tracts forming the arcuate fasciculus can be quantified and visualized using ...
    • Hallucinations in acutely admitted patients with psychosis, and effectiveness of risperidone, olanzapine, quetiapine, and ziprasidone: a pragmatic, randomized study 

      Johnsen, Erik; Sinkeviciute, Igne; Løberg, Else-Marie; Kroken, Rune A.; Hugdahl, Kenneth; Jørgensen, Hugo A. (Peer reviewed; Journal article, 2013-09-30)
      Background Hallucinations are prevalent in schizophrenia and related psychotic disorders and may have severe consequences for the affected patients. Antipsychotic drug trials that specifically address the anti-hallucinatory ...
    • Health-related quality of life of long-term patients receiving opioid agonist therapy: a nested prospective cohort study in Norway 

      Aas, Christer Frode; Vold, Jørn Henrik; Skurtveit, Svetlana; Lim, Aaron G.; Ruths, Sabine; Kamrul, Islam; Askildsen, Jan Erik; Løberg, Else-Marie; Fadnes, Lars T.; Johansson, Kjell Arne (Journal article; Peer reviewed, 2020)
      Background Opioid dependence carries the highest disease burden of all illicit drugs. Opioid agonist therapy (OAT) is an evidence-based medical intervention that reduces morbidity and mortality. There is limited knowledge ...
    • Impact of clinical and sociodemographic factors on fatigue among patients with substance use disorder: a cohort study from Norway for the period 2016–2020 

      Vold, Jørn Henrik; Gjestad, Rolf; Aas, Christer Frode; Chalabianloo, Fatemeh; Skurtveit, Svetlana; Løberg, Else-Marie; Johansson, Kjell Arne; Fadnes, Lars T. (Journal article; Peer reviewed, 2020)
      Background The impact of clinical and sociodemographic factors on fatigue remains unknown among patients with substance use disorders (SUD). This study aims to evaluate fatigue among patients with SUD using a nine-item ...
    • Impact of glutamate levels on neuronal response and cognitive abilities in schizophrenia 

      Falkenberg, Liv Eggset; Westerhausen, René; Craven, Alexander R.; Kroken, Rune A.; Løberg, Else-Marie; Specht, Karsten; Hugdahl, Kenneth (Peer reviewed; Journal article, 2014-04-02)
      Schizophrenia is characterized by impaired cognitive functioning, and brain regions involved in cognitive control processes show marked glutamatergic abnormalities. However, it is presently unclear whether aberrant neuronal ...
    • Integrated care of severe infectious diseases to people with substance use disorders; a systematic review 

      Vold, Jørn Henrik; Aas, Christer Frode; Leiva, Rafael Alexander Mo; Vickerman, Peter; Chalabianloo, Fatemeh; Løberg, Else-Marie; Johansson, Kjell Arne; Fadnes, Lars T. (Peer reviewed; Journal article, 2019)
      Background: Various integrated care models have been used to improve treatment completion of medications for chronic hepatitis B virus (HBV), chronic hepatitis C virus (HCV), Mycobacterium tuberculosis (TB), and Human ...
    • Integrated treatment of hepatitis C virus infection among people who inject drugs: study protocol for a randomised controlled trial (INTRO-HCV) 

      Fadnes, Lars T.; Aas, Christer Frode; Vold, Jørn Henrik; Ohldieck, Christian; Leiva, Rafael Alexander Mo; Chalabianloo, Fatemeh; Skurtveit, Svetlana; Lygren, Ole Jørgen; Dalgard, Olav; Vickerman, Peter; Midgard, Håvard; Løberg, Else-Marie; Johansson, Kjell Arne (Peer reviewed; Journal article, 2019-11-08)
      Background: A large proportion of people who inject drugs (PWID) living with hepatitis C virus (HCV) infection have not been treated. It is unknown whether inclusion of HCV diagnostics and treatment into integrated substance ...
    • Intra-Regional Glu-GABA vs Inter-Regional Glu-Glu Imbalance: A 1H-MRS Study of the Neurochemistry of Auditory Verbal Hallucinations in Schizophrenia. 

      Hjelmervik, Helene; Craig-Craven, Alexander Richard; Sinkeviciute, Igne; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Gruner, Eli Renate; Hugdahl, Kenneth (Peer reviewed; Journal article, 2019-10-18)
      Glutamate (Glu), gamma amino-butyric acid (GABA), and excitatory/inhibitory (E/I) imbalance have inconsistently been implicated in the etiology of schizophrenia. Elevated Glu levels in language regions have been suggested ...
    • Left temporal lobe structural and functional abnormality underlying auditory hallucinations in schizophrenia 

      Hugdahl, Kenneth; Løberg, Else-Marie; Nygård, Merethe (Peer reviewed; Journal article, 2009-05-01)
      In this article, we have reviewed recent findings from our laboratory, originally presented in Hugdahl et al. (2008) . These findings reveal that auditory hallucinations in schizophrenia should best be conceptualized as ...