Browsing Bergen Open Research Archive by Author "Larsen, Alf Inge"
Now showing items 1-20 of 28
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The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication
Brügger-Andersen, Trygve; Bostad, Leif; Sandnes, Dagny A.; Larsen, Alf Inge; Bonarjee, Vernon V. S.; Barvik, Ståle; Melberg, Tor; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2010-01-27)Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation ... -
Adding stress biomarkers to high-sensitivity cardiac troponin for rapid non-ST-elevation myocardial infarction rule-out protocols
Restan, Ingar Ziad; Sanchez, Ana Yufera; Steiro, Ole-Thomas; Lopez-Ayala, Pedro; Tjora, Hilde Lunde; Langørgen, Jørund; Omland, Torbjørn; Boeddinghaus, Jasper; Nestelberger, Thomas; Koechlin, Luca; Collinson, Paul; Bjørneklett, Rune Oskar; Vikenes, Kjell; Strand, Heidi; Skadberg, Øyvind; Mjelva, Øistein; Larsen, Alf Inge; Vernon, Bonarjee; Mueller, Christian; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2022)Aims This study tested the hypothesis that combining stress-induced biomarkers (copeptin or glucose) with high-sensitivity cardiac troponin (hs-cTn) increases diagnostic accuracy for non-ST-elevation myocardial infarction ... -
Aerobic high-intensity interval exercise training in patients with angina and no obstructive coronary artery disease: feasibility and physiological effects
Larsen, Alf Inge; Sæland, Charlotte; Vegsundvåg, Johnny Åge; Skadberg, Mette Storebø; Nilsen, Jorunn; Butt, Noreen; Ushakova, Anastasia; Valborgland, Torstein; Munk, Peter Scott; Isaksen, Kjetil (Journal article; Peer reviewed, 2023)Aims Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims ... -
Automatic Estimation of Coronary Blood Flow Velocity Step 1 for Developing a Tool to Diagnose Patients With Micro-Vascular Angina Pectoris
Khanmohammadi, Mahdieh; Sæland, Charlotte; Engan, Kjersti; Eftestøl, Trygve Christian; Larsen, Alf Inge (Peer reviewed; Journal article, 2019-01-22)Aim: Our aim was to automatically estimate the blood velocity in coronary arteries using cine X-ray angiographic sequence. Estimating the coronary blood velocity is a key approach in investigating patients with angina ... -
Blood Lactate AUC Is a Sensitive Test for Evaluating the Effect of Exercise Training on Functional Work Capacity in Patients with Chronic Heart Failure
Valborgland, Torstein; Isaksen, Kjetil; Munk, Peter Scott; Larsen, Alf Inge (Journal article; Peer reviewed, 2021)Purpose. Exercise training is an essential treatment option for patients with chronic heart failure (CHF). However, it remains controversial, which surrogate measures of functional work capacity are most reliable. The ... -
Burden of treatment in patients with chronic heart failure – A cross-sectional study
Nordfonn, Oda Karin; Morken, Ingvild Margreta; Bru, Lars Edvin; Larsen, Alf Inge; Husebø, Anne Marie Lunde (Journal article; Peer reviewed, 2021)Background Patients with heart failure (HF) must manage both a demanding treatment regimen and self-care, which may lead to a burden of treatment. The purpose of this study was to assess the levels of burdens from treatment ... -
Cardiac arrest as a reportable condition: A cohort study of the first 6 years of the Norwegian out-of-hospital cardiac arrest registry
Tjelmeland Myrhaugen, Ingvild Beathe; Alm-Kruse, Kristin; Andersson, Lars-Jøran; Bratland, Ståle; Hafstad, Arne Ketil; Haug, Bjørn; Langørgen, Jørund; Larsen, Alf Inge; Lindner, Thomas Werner; Nilsen, Jan Erik; Olasveengen, Theresa Mariero; Søreide, Eldar; Skogvoll, Eirik; Kramer-Johansen, Jo (Journal article; Peer reviewed, 2020)Objectives The Norwegian Cardiac Arrest Registry (NorCAR) was established in 2013 when cardiac arrest became a mandatory reportable condition. The aim of this cohort study is to describe how the world’s first mandatory, ... -
Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study
Bergland, Anne Katrine; Sønnesyn, Hogne; Dalen, Ingvild; Rodriguez-Mateos, Ana; Berge, Rolf Kristian; Melvær, Giil Lasse; Rajendran, Lawrence; Siow, Richard; Tassotti, Michele; Larsen, Alf Inge; Aarsland, Dag (Peer reviewed; Journal article, 2019-06-11)Background: Anthocyanins may protect against cardiovascular related cognitive decline and dementia. Objective: Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of ... -
Effects of interval training on inflammatory biomarkers in patients with ischemic heart failure
Isaksen, Kjetil; Halvorsen, Bente; Munk, Peter Scott; Aukrust, Pål; Larsen, Alf Inge (Peer reviewed; Journal article, 2019)Objectives. Exercise training has been proposed to have anti-inflammatory effects. We examined whether aerobic interval training (AIT) can attenuate the inflammatory response in ischemic heart failure (HF) as measured by ... -
Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial
Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Oesterhus, Ragnhild; Dalen, Ingvild; Larsen, Alf Inge; Fladby, Tormod; Brooker, Helen; Wesnes, Keith A.; Ballard, Clive; Aarsland, Dag (Journal article; Peer reviewed, 2020)Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ... -
Estimating cardiac output from coronary CT angiography: an individualized compartment model in comparison to the Stewart–Hamilton method
Leiknes, Jon Bjarne; Hiorth, Aksel; Havnen, Jorunn; Greve, Ole Jacob; Kurz, Kathinka Dæhli; Larsen, Alf Inge (Journal article; Peer reviewed, 2023)Background: Attenuation is correlated with the concentration of contrast medium (CM) in the arteries. The cardiac output (CO) affects the concentration of CM in the circulatory system; therefore, CO affects the time–density ... -
Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction
Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Journal article; Peer reviewed, 2021)Aims Whether an exercise training intervention is associated with reduction in long-term high-sensitivity cardiac troponin T (hs-cTnT) concentration (a biomarker of subclinical myocardial injury) in patients with heart ... -
Exercise training and high-sensitivity cardiac troponin-I in patients with heart failure with reduced ejection fraction
Riveland, Egil Aarstad; Valborgland, Torstein; Ushakova, Anastasia; Skadberg, Øyvind; Karlsen, Trine; Hole, Torstein Laurits; Støylen, Asbjørn; Dalen, Håvard; Videm, Vibeke; Koppen, Elias; Linke, Axel; Delagardelle, Charles; Van Craenenbroeck, Emeline M.; Beckers, Paul; Prescott, Eva; Halle, Martin; Omland, Torbjørn; Ellingsen, Øyvind; Larsen, Alf Inge (Journal article; Peer reviewed, 2024)Aims The aims of this sub-study of the SMARTEX trial were (1) to evaluate the effects of a 12-week exercise training programme on serum levels of high sensitivity cardiac troponin I (hs-cTnI) in patients with moderate ... -
Factors predicting the use of therapeutic hypothermia and survival in unconscious out-of-hospital cardiac arrest patients admitted to the ICU
Lindner, Thomas Werner; Langørgen, Jørund; Sunde, Kjetil; Larsen, Alf Inge; Kvaløy, Jan Terje; Heltne, Jon-Kenneth; Drægni, Tomas; Søreide, Eldar (Peer reviewed; Journal article, 2013-07-23)Introduction: Therapeutic hypothermia (TH) after out-of-hospital cardiac arrest (OHCA) was adopted early in Norway. Since 2004 the general recommendation has been to cool all unconscious OHCA patients treated in the intensive ... -
Guideline-Recommended Time Less Than 90 Minutes From ECG to Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Is Associated with Major Survival Benefits, Especially in Octogenarians: A Contemporary Report in 11 226 Patients from NORIC
Larsen, Alf Inge; Løland, Kjetil Halvorsen; Hovland, Siren; Bleie, Øyvind; Eek, Christian; Fossum, Eigil; Trovik, Thor; Juliebø, Vibeke; Hegbom, Knut; Moer, Rasmus; Larsen, Tomas; Uchto, Michael; Rotevatn, Svein (Journal article; Peer reviewed, 2022)Background Using contemporary data from NORIC (Norwegian Registry of Invasive Cardiology) we investigated the predictive value of patient age and time from ECG diagnosis to sheath insertion (ECG‐2‐sheath) in primary ... -
High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction
Ellingsen, Øyvind; Halle, Martin; Conraads, Viviane; Støylen, Asbjørn; Dalen, Håvard; Delagardelle, Charles; Larsen, Alf Inge; Hole, Torstein; Mezzani, Alessandro; Van Craenenbroeck, Emeline M.; Videm, Vibeke; Beckers, Paul; Christle, Jeffrey W.; Winzer, Ephraim; Mangner, Norman; Woitek, Felix; Höllriegel, Robert; Pressler, Axel; Monk-Hansen, Tea; Snoer, Martin; Feiereisen, Patrick; Valborgland, Torstein; Kjekshus, John; Hambrecht, Rainer; Gielen, Stephan; Karlsen, Trine; Prescott, Eva; Linke, Axel (Peer reviewed; Journal article, 2017-02)Background: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart ... -
A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control study
Pönitz, Volker; Govers-Riemslag, José W.; Cate, Hugo ten; Oerle, Rene van; Brügger-Andersen, Trygve; Grundt, Heidi; Næsgaard, Patrycja A.; Pritchard, David; Larsen, Alf Inge; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2010-04-15)Background: The pathophysiological pathways resulting in Late Stent Thrombosis (LST) remain uncertain. Findings from animal studies indicate a role of the intrinsic coagulation pathway in arterial thrombus formation, while ... -
Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial
Larsen, Alf Inge; Grejs, Anders Morten; Vistisen, Simon Tilma; Strand, Kristian; Skadberg, Øyvind; Jeppesen, Anni Nørgaard; Duez, Christophe H. V.; Kirkegaard, Hans; Søreide, Eldar (Journal article; Peer reviewed, 2022)Introduction Short term hypothermia has been suggested to have cardio protective properties in acute myocardial infarction (AMI) by reducing infarct size as assessed by troponins. There are limited data on the kinetics ... -
The Localization and Characterization of Ischemic Scars in relation to the Infarct Related Coronary Artery Assessed by Cardiac Magnetic Resonance and a Novel Automatic Postprocessing Method
Woie, Leik; Engan, Kjersti; Eftestøl, Trygve; Larsen, Alf Inge; Ørn, Stein (Peer reviewed; Journal article, 2015)Aims. The correspondence between the localization and morphology of ischemic scars and the infarct related artery (IRA) by use of cardiac magnetic resonance imaging and a novel automatic postprocessing method. Methods and ... -
N-terminal pro-B-type natriuretic peptide for prediction of ventricular arrhythmias: Data from the SMASH study
Sourour, Nur; Riveland, Egil Aarstad; Næsgaard, Patrycja; Kjekshus, Harald; Larsen, Alf Inge; Omland, Torbjørn; Røsjø, Helge Rørvik; Myhre, Peder Langeland (Journal article; Peer reviewed, 2023)Background Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations predict heart failure (HF) and mortality, but whether NT-proBNP predicts ventricular arrhythmias (VA) is not clear. Hypothesis We ...