Browsing Bergen Open Research Archive by Author "Leenders, William P.J."
Now showing items 1-2 of 2
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Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways
Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ... -
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin
Biedermann, Julia; Preussler, Mathias; Conde, Marina; Peitzsch, Mirko; Richter, Susan; Wiedemuth, Ralf; Abou-El-Ardat, Khalil; Krüger, Alexander; Meinhardt, Mathias; Schackert, Gabriele; Leenders, William P.J.; Herold-Mende, Christel; Niclou, Simone Pierrette; Bjerkvig, Rolf; Eisenhofer, Graeme; Temme, Achim; Seifert, Michael; Kunz-Schughart, Leoni A.; Schröck, Evelin; Klink, Barbara (Peer reviewed; Journal article, 2019-12-16)IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ...