• Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways 

      Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)
      Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ...
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Peer reviewed; Journal article, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
    • Comparing the impact of upfront radiosurgery versus expectation in vestibular schwannoma (the V-REX study): protocol for a randomised, observer-blinded, 4-year, parallel-group, single-centre, superiority study 

      Dhayalan, Dhanushan; Tveiten, Øystein Vesterli; Goplen, Frederik Kragerud; Finnkirk, Monica Katrine; Storstein, Anette Margrethe; Gruner, Eli Renate; Lund-Johansen, Morten (Journal article; Peer reviewed, 2021)
      Introduction The optimal management of small-sized to medium-sized vestibular schwannoma (VS) is a matter of controversy. Clinical results of the prevailing treatment modalities (microsurgery, stereotactic radiosurgery ...
    • Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma 

      Håvik, Aril Løge; Bruland, Ove; Dhayalan, Dhanushan; Lund-Johansen, Morten; Knappskog, Per (Journal article; Peer reviewed, 2020)
      Introduction: Ionizing radiation is a known etiologic factor in tumorigenesis and its role in inducing malignancy in the treatment of vestibular schwannoma has been debated. The purpose of this study was to identify a copy ...
    • Gene expression profiling of meningiomas: current status after a decade of microarray-based transcriptomic studies 

      Aarhus, Mads; Lund-Johansen, Morten; Knappskog, Per (Peer reviewed; Journal article, 2011-01-14)
      Purpose This article provides a review of the transcriptomic expression profiling studies that have been performed on meningiomas so far. We discuss some future prospects and challenges ahead in the field of gene expression ...
    • Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma 

      Håvik, Aril Løge; Bruland, Ove; Miletic, Hrvoje; Poulsgaard, Lars; Scheie, David; Fugleholm, Kåre; Lund-Johansen, Morten; Knappskog, Per Morten (Journal article; Peer reviewed, 2022)
      Introduction: Malignant peripheral nerve sheath tumor of the vestibulocochlear nerve (VN-MPNST) is exceedingly rare and carries a poor prognosis. Little is known about its underlying genetics and in particular the process ...
    • Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis 

      Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019-04-10)
      Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ...
    • Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma 

      Obad, Nina; Espedal, Heidi; Jirík, Radovan; Sakariassen, Per Øystein; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Taxt, Torfinn; Niclou, Simone Pierrette; Bjerkvig, Rolf; Keunen, Olivier (Peer reviewed; Journal article, 2017)
      Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy ...
    • Long-term effects of conservative management of vestibular schwannoma on dizziness, balance, and caloric function 

      Nilsen, Kathrin Skorpa; Lund-Johansen, Morten; Nordahl, Stein Helge; Finnkirk, Monica Katrine; Goplen, Frederik Kragerud (Peer reviewed; Journal article, 2019)
      Objectives: To study the development of dizziness, caloric function, and postural sway during long-term observation of untreated vestibular schwannoma patients. Study Design: Retrospective review of a prospectively maintained ...
    • Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts 

      Aarhus, Mads; Helland, Christian Andre; Lund-Johansen, Morten; Wester, Knut; Knappskog, Per (Peer reviewed; Journal article, 2010-02-26)
      Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the temporal fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and ...
    • Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies 

      Keunen, Olivier; Taxt, Torfinn; Grüner, Renate; Lund-Johansen, Morten; Tonn, Joerg-Christian; Pavlin, Tina; Bjerkvig, Rolf; Niclou, Simone P.; Thorsen, Frits Alan (Peer reviewed; Journal article, 2014-09-30)
      The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology ...
    • Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Surgical Procedures, Complications, and Postoperative Outcomes 

      Teklemariam, Tsegazeab Laeke; Aklilu, Abenezer Tirsit; Kassahun, Azarias; Sahlu, Abat; Yesehak, Betelehem; Getahun, Samuel; Zenebe, Eyob; Deyassa, Negussie; Moen, Bente Elisabeth; Lund-Johansen, Morten; Sundstrøm, Terje (Journal article; Peer reviewed, 2021)
      Background Traumatic brain injury (TBI) is an important cause of trauma-related mortality and morbidity in Ethiopia. There are significant resource limitations along the entire continuum of care, and little is known about ...
    • Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Trauma Causes, Injury Types, and Clinical Presentation 

      Teklemariam, Tsegazeab Laeke; Aklilu, Abenezer Tirsit; Kassahun, Azarias; Sahlu, Abat; Debebe, Tequam; Yesehak, Betelehem; Masresha, Samuel; Deyassa, Negussie; Moen, Bente Elisabeth; Lund-Johansen, Morten; Sundstrøm, Terje (Journal article; Peer reviewed, 2021)
      Background Traumatic brain injury (TBI) is a public health problem in Ethiopia. More knowledge about the epidemiology and neurosurgical management of TBI patients is needed to identify possible focus areas for quality ...
    • The SH3PXD2A-HTRA1 fusion transcript is extremely rare in Norwegian sporadic vestibular schwannoma patients 

      Taule-Sivertsen, Peter; Bruland, Ove; Håvik, Aril Løge; Bratland, Eirik; Lund-Johansen, Morten; Knappskog, Per Morten (Journal article; Peer reviewed, 2021)
      Introduction Vestibular schwannoma (VS) is a benign intracranial tumor in which the underlying genetics is largely uncertain, apart from mutations in the tumor suppressor gene NF2. Alternative tumorigenic mechanisms have ...