• Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy 

      Braun, Fabian; Abed, Ahmed; Sellung, Dominik; Rogg, Manuel; Woidy, Mathias; Eikrem, Øystein Solberg; Wanner, Nicola; Gambardella, Jessica; Laufer, Sandra; Haas, Fabian; Wong, Milagros; Dumoulin, Bernhard; Rischke, Paula; Mühlig, Anne; Sachs, Wiebke; von Cossel, Katharina M; Schulz, Kristina; Muschol, Nicole; Gersting, Sören; Muntau, Ania C.; Kretz, Oliver; Hahn, Oliver; Rinschen, Markus; Mauer, Michael; Bork, Tillmann; Grahammer, Florian; Liang, Wei; Eierhoff, Thorsten; Römer, Winfried; Hansen, Arne; Meyer-Schwesinger, Catherine; Iaccarino, Guido; Tøndel, Camilla; Marti, Hans Peter; Najafian, Behzad; Puelles, Victor G; Schell, Christoph; Huber, Tobias B (Journal article; Peer reviewed, 2023)
      Current therapies for Fabry disease are based on reversing intracellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby ...
    • The Association of Sarcopenia and Central Obesity with Mortality Risk in Patients with Chronic Kidney Disease – a 2-Year Observational Study 

      Dahl, Helene; Rosendahl-Riise, Hanne; Marti, Hans Peter; Dierkes, Jutta (Journal article; Peer reviewed, 2023)
      Background Patients with chronic kidney disease (CKD) face numerous challenges regarding their nutritional status, including undernutrition, wasting, overweight, and obesity. However, there is a gap in the knowledge on ...
    • AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model 

      Chen, Tony Jialiang; Mydel, Piotr Mateusz; Benedyk-Machaczka, Małgorzata; Kamińska, Marta; Kalucka, Urszula; Blø, Magnus; Furriol, Jessica; Gausdal, Gro; Lorens, James Bradley; Osman, Tarig Al-Hadi; Marti, Hans Peter (Journal article; Peer reviewed, 2021)
      AXL tyrosine kinase activation enhances cancer cell survival, migration, invasiveness, and promotes drug resistance. AXL overexpression is typically detected in a high percentage of renal cell carcinomas (RCCs) and is ...
    • Cardiovascular changes in young renal failure patients 

      Tøndel, Camilla; Marti, Hans Peter (Journal article; Peer reviewed, 2021)
      Progresses in medical care of severe kidney disease and congenital anomalies of kidney and urinary tract make it possible for a higher percentage of young renal failure patients to survive and enter adulthood. There is ...
    • Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use 

      Stalund, Ida Viken; Grønseth, Heidi Lønne; Reinholt, Finn P.; Svarstad, Einar; Marti, Hans Peter; Leh, Sabine (Journal article; Peer reviewed, 2022)
      Background and objectives: Persons with intravenous drug use have a higher risk of developing CKD compared with the general population. In Norway, deposits of polyvinylpyrrolidone have been observed in kidney biopsies taken ...
    • Cystatin C proteoforms in chronic kidney disease 

      Dahl, Helene; Meyer, Klaus; Sandnes, Kristina; Welland, Natasha Lervaag; Arnesen, Iselin; Marti, Hans Peter; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)
      Cystatin C, a cysteine protease inhibitor, is used as a biomarker of renal function. It offers several advantages compared to creatinine, and formulas for the estimation of the glomerular filtration rate based on cystatin ...
    • A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice 

      O'Keeffe, Maria; Oterhals, Åge; Weishaupt, Hrafn; Leh, Sabine; Ulvik, Arve; Ueland, Per Magne; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)
      Purpose The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish ...
    • Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life 

      Gjerde, Anna; Skrunes, Rannveig; Reisæter, Anna Varberg; Marti, Hans Peter; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2021)
      Introduction: Previous studies have revealed that individuals with low birth weight (LBW) have higher risk of chronic kidney disease (CKD) and that LBW and CKD cluster in families. This study investigates how familial ...
    • Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca2+ Signaling Similar to Fabry Disease 

      Elsaid, Hassan Osman Alhassan; Tjeldnes, Håkon; Rivedal, Mariell Lossius; Serre, Camille Julia; Eikrem, Øystein Solberg; Svarstad, Einar; Tøndel, Camilla; Marti, Hans Peter; Furriol, Jessica; Babickova, Janka (Journal article; Peer reviewed, 2022)
      Fabry disease (FD) is an X-linked inborn metabolic disorder due to partial or complete lysosomal α-galactosidase A deficiency. FD is characterized by progressive renal insufficiency and cardio- and cerebrovascular involvement. ...
    • Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts 

      Kipp, Anne; Marti, Hans Peter; Babickova, Janka; Nakken, Sigrid; Leh, Sabine; Strøm Halden, Thea Anine; Jenssen, Trond; Vikse, Bjørn Egil; Åsberg, Anders; Spagnoli, Giulio; Furriol, Jessica (Journal article; Peer reviewed, 2023)
      Background Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM ...
    • Identification and characterization of aptameric inhibitors of human neutrophil elastase 

      Malicki, Stanisław; Książek, Mirosław; Sochaj Gregorczyk, Alicja; Kaminska, Marta; Golda, Anna; Chruścicka, Barbara; Mizgalska, Danuta; Potempa, Jan; Marti, Hans Peter; Kozieł, Joanna; Wieczorek, Maciej; Pieczykolan, Jerzy; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2023)
      Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases ...
    • Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe 

      Malicki, Stanisław; Pucelik, Barbara; Żyła, Edyta; Benedyk-Machaczka, Małgorzata; Gałan, Wojciech; Golda, Anna; Sochaj-Gregorczyk, Alicja; Kaminska, Marta; Encarnação, João Crispim; Chruścicka, Barbara; Marti, Hans Peter; Chen, Tony Jialiang; Magiera-Mularz, Katarzyna; Zięba, Bartosz; Holak, Tad A.; Dabrowski, Janusz M.; Czarna, Anna; Kozieł, Joanna; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2022-06-01)
      Immune checkpoint targeting immunotherapy has revolutionized the treatment of certain cancers in the recent years. Determination of the status of immune checkpoint expression in particular cancers may assist decision making. ...
    • Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats 

      Vildmyren, Iselin Thowsen; Oterhals, Åge; Leh, Sabine; Samuelsen, Tor Andreas; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2022)
      Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the ...
    • Low Immunization Rate in Kidney Transplant Recipients Also After Dose 2 of the BNT162b2 Vaccine: Continue to Keep Your Guard up! 

      Midtvedt, Karsten; Tran, Trung; Parker, Krystina; Marti, Hans Peter; Stenehjem, Aud Eldrid; Gøransson, Lasse Gunnar; Soldal, Kari Mørkve; Madsen, Camilla; Smedbråten, Julia; Vaage, Eline Benno; Lund-Johansen, Fridtjof; Åsberg, Anders (Journal article, 2021)
    • A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome 

      Hoel, Fredrik; Hoel, August; Pettersen, Ina Katrine Nitschke; Rekeland, Ingrid Gurvin; Risa, Kristin; Alme, Kine; Sørland, Kari; Fosså, Alexander; Lien, Katarina; Herder, Ingrid; Thurmer, Hanne; Gotaas, Merethe Otelie Eide; Schäfer, Christoph; Berge, Rolf K.; Sommerfelt, Kristian; Marti, Hans Peter; Dahl, Olav; Mella, Olav; Fluge, Øystein; Tronstad, Karl Johan (Journal article; Peer reviewed, 2021)
      Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic ...
    • Medication Prescription, Common Side-effects, and Nutritional Status are Associated in Patients With Chronic Kidney Disease 

      Dahl, Helene; Sandblost, Silje Regine Thue; Welland, Natasha Lervaag; Sandnes, Kristina; Sekse, Ingegjerd; Sæle, Kristin; Marti, Hans Peter; Holst, Lone; Dierkes, Jutta (Journal article; Peer reviewed, 2022)
      Objective Chronic kidney disease (CKD) is associated with metabolic, nutritional, and extra-renal changes, as well as a high rate of comorbidities, which necessitates the prescription of numerous medications. Patients ...
    • A multiomics disease progression signature of low-risk ccRCC 

      Strauss, Philipp; Rivedal, Mariell; Scherer, Andreas; Eikrem, Øystein Solberg; Nakken, Sigrid; Beisland, Christian; Bostad, Leif; Flatberg, Arnar; Skandalou, Eleni; Beisvag, Vidar; Furriol, Jessica; Marti, Hans Peter (Journal article; Peer reviewed, 2022)
      Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ...
    • Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target 

      Eikrem, Øystein Solberg; Lillefosse, Bjørnar; Delaleu, Nicolas; Strauss, Philipp; Osman, Tarig Al-Hadi; Vikse, Bjørn Egil; Debiec, Hanna; Ronco, Pierre; Sekulic, Miroslav; Koch, Even Evjen; Furriol, Jessica; Leh, Sabine; Marti, Hans Peter (Journal article; Peer reviewed, 2023)
      Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, ...
    • Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease 

      Elsaid, Hassan Osman Alhassan; Rivedal, Mariell Lossius; Skandalou, Eleni; Svarstad, Einar; Tøndel, Camilla; Birkeland, Even; Eikrem, Øystein Solberg; Babickova, Janka; Marti, Hans Peter; Furriol, Jessica (Journal article; Peer reviewed, 2023)
      Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ...
    • Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)
      Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ...