• 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy 

      Joubert, Bonnie R.; Håberg, Siri Eldevik; Nilsen, Roy Miodini; Wang, Xuting; Vollset, Stein Emil; Murphy, Susan K; Huang, Zhiqing; Hoyo, Cathrine; Midttun, Øivind; Cupul-Uicab, Lea A; Ueland, Per Magne; Wu, Michael C; Nystad, Wenche; Bell, Douglas A; Peddada, Shyamal D; London, Stephanie J (Peer reviewed; Journal article, 2012-10)
      Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple ...
    • Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...
    • The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study 

      Luu, Hung N.; Paragomi, Pedram; Wang, Renwei; Huang, Joyce Y.; Adams-Haduch, Jennifer; Midttun, Øivind; Ulvik, Arve; Nguyen, Tin C.; Brand, Randall E.; Gao, Yutang; Ueland, Per Magne; Yuan, Jian-Min (Journal article; Peer reviewed, 2022-04-28)
      Background: Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic ...
    • Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study 

      Bakker, Lieke; Ramakers, Inez H. G. B.; van Boxtel, Martin P. J.; Schram, Miranda T.; Stehouwer, Coen D.A.; Van Der Kallen, Carla J.; Dagnelie, Pieter; Van Greevenbroek, Marleen M.J.; Wesselius, Anke; Midttun, Øivind; Ueland, Per M.; Verhey, Frans; Eussen, Simone; Köhler, Sebastian (Journal article; Peer reviewed, 2021)
      Aims/hypothesis Studies investigating associations between kynurenines and cognitive function have generally been small, restricted to clinical samples or have found inconsistent results, and associations in the general ...
    • Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine; Trøseid, Marius; Midttun, Øivind; Ueland, Per Magne; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Kummen, Martin; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio ...
    • Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats. 

      Vikøren, Linn A.; Drotningsvik, Aslaug; Midttun, Øivind; McCann, Adrian; Bergseth, Marthe Tønder; Austgulen, Maren H.; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)
      Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. ...
    • Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study 

      Chuang, Shu-Chun; Boeing, Heiner; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Bueno-de-Mesquita, Bas; Lajous, Martin; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Kaaks, Rudolf; Küehn, Tilman; Pischon, Tobias; Drogan, Dagmar; Tjønneland, Anne; Overvad, Kim; Quirós, J. Ramón; Agudo, Antonio; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J.; Travis, Ruth C.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H.; Weiderpass, Elisabete; Palmqvist, Richard; Ljuslinder, Ingrid; Gunter, Marc; Lu, Yunxia; Cross, Amanda J.; Riboli, Elio; Vineis, Paolo; Aleksandrova, Krasimira (Peer reviewed; Journal article, 2016-02-25)
      Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). ...
    • Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival 

      Johansson, Mattias; Anouar, Fanidi; Muller, David C.; Bassett, Julie K.; Midttun, Øivind; Vollset, Stein Emil; Travis, Ruth C.; Palli, Domenico; Mattiello, Amalia; Sieri, Sabina; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Ljungberg, Börje; Hallmans, Göran; Weiderpass, Elisabete; Skeie, Guri; Gonzalez, Carlos A.; Dorronsoro, Miren; Peeters, Petra H.; Bueno-de-Mesquita, H. B(as).; Ros, Martine M.; Ruault, Marie-Christine Boutron; Fagherazzi, Guy; Clavel, Françoise; Sanchez, Maria-Jose; Gurrea, Aurelio Barricarte; Navarro, Carmen; Quirós, J. Ramón; Overvad, Kim; Tjønneland, Anne; Aleksandrova, Krassimira; Vineis, Paolo; Gunter, Marc J.; Kaaks, Rudolf; Giles, Graham; Relton, Caroline; Riboli, Elio; Boeing, Heiner; Ueland, Per Magne; Severi, Gianluca; Brennan, Paul (Peer reviewed; Journal article, 2014)
      Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The ...
    • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

      Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Peer reviewed; Journal article, 2017-06)
      Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
    • Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium 

      Muller, David C.; Larose, Tricia L; Hodge, Allison; Guida, Florence; Langhammer, Arnulf; Grankvist, Kjell; Meyer, Klaus; Cai, Qiuyin; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Albanes, Demetrius; Giles, Graham G.; Sesso, Howard D.; Lee, I-Min; Gaziano, J. Michael; Yuan, Jian-Min; Hoffman Bolton, Judith; Buring, Julie E.; Visvanathan, Kala; Le Marchand, Loic; Purdue, Mark P.; Caporaso, Neil E.; Midttun, Øivind; Ueland, Per Magne; Prentice, Ross L.; Weinstein, Stephanie J.; Stevens, Victoria L.; Zheng, Wei; Blot, William J.; Shu, Xiao-Ou; Zhang, Xuehong; Xiang, Yong-Bing; Koh, Woon-Puay; Hveem, Kristian; Thomson, Cynthia A.; Pettinger, Mary; Engström, Gunnar; Brunnström, Hans; Milne, Roger L.; Stampfer, Meir J.; Han, Jiali; Johansson, Mikael; Brennan, Paul; Severi, Gianluca; Johansson, Mattias (Peer reviewed; Journal article, 2019-01-03)
      Objectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but ...
    • Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort 

      Fanidi, Anouar; Muller, David C.; Midttun, Øivind; Ueland, Per Magne; Vollset, Stein Emil; Relton, Caroline; Vineis, Paolo; Weiderpass, Elisabete; Skeie, Guri; Brustad, Magritt; Palli, Domenico; Tumino, Rosario; Grioni, Sara; Sacerdote, Carlotta; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Cadeau, Claire; Huerta, José María; Sánchez, María-José; Agudo, Antonio; Lasheras, Cristina; Quirós, J. Ramón; Chamosa, Saioa; Riboli, Elio; Travis, Ruth C; Ward, Heather; Murphy, Neil; Khaw, Kay-Tee; Trichopoulou, Antonia; Lagiou, Pagona; Papatesta, Eleni-Maria; Boeing, Heiner; Kühn, Tilman; Katzke, Verena; Steffen, Annika; Johansson, Anders; Brennan, Paul; Johansson, Mattias (Peer reviewed; Journal article, 2016-11-04)
      Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective ...
    • A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Clasen, Joanna L; Heath, Alicia K.; Van Puyvelde, Heleen; Huybrechts, Inge; Park, Jin Young; Ferrari, Pietro; Johansson, Mattias; Scelo, Ghislaine; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Dahm, Christina C; Halkjær, Jytte; Olsen, Anja; Johnson, Theron; Katzke, Verena; Schulze, Matthias B; Masala, Giovanna; Segrado, Francesco; De Magistris, Maria Santucci; Sacerdote, Carlotta; Ocké, Marga C; Luján-Barroso, Leila; Ching-López, Ana; Huerta, José María; Ardanaz, Eva; Amiano, Pilar; Ericson, Ulrika; Manjer, Jonas; Gylling, Björn; Johansson, Ingegerd; Schmidt, Julie; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J; Muller, David C (Journal article; Peer reviewed, 2021)
      Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. ...
    • Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway 

      Degerud, Eirik Magnus Meek; Hoff, Rune; Nygård, Ottar; Strand, Elin; Nilsen, Dennis W. T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; De Vogel, Stefan; Dierkes, Jutta (Peer reviewed; Journal article, 2016)
      Background/Objectives: Seasonal variation may reduce the validity of 25-hydroxyvitamin D (25OHD) as a biomarker of vitamin D status. Here we aimed to identify potential determinants of seasonal variation in 25OHD concentrations ...
    • Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease 

      Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2019-09-09)
      Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ...
    • DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy 

      Reese, Sarah E; Zhao, Shanshan; Wu, Michael C; Joubert, Bonnie R; Parr, Christine Louise; Håberg, Siri Eldevik; Ueland, Per Magne; Nilsen, Roy Miodini; Midttun, Øivind; Vollset, Stein Emil; Peddada, Shyamal D; Nystad, Wenche; London, Stephanie J (Peer reviewed; Journal article, 2017-04)
      Background: Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport smoking and smokers tend to have lower follow-up ...
    • Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial 

      Helland, Anita; Bratlie, Marianne; Hagen, Ingrid V.; Midttun, Øivind; Sveier, Harald; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)
      Purpose Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular ...
    • Effect of cod residual protein supplementation on markers of glucose regulation in lean adults: A randomized double-blind study 

      Vildmyren, Iselin; Halstensen, Alfred; McCann, Adrian; Midttun, Øivind; Ueland, Per Magne; Oterhals, Åge; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2020)
      Large quantities of protein-rich cod residuals, which are currently discarded, could be utilized for human consumption. Although fish fillet intake is related to beneficial health effects, little is known about the potential ...
    • The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites 

      Aarsland, Tore Ivar Malmei; Leskauskaite, Ieva; Midttun, Øivind; Ulvik, Arve; Ueland, Per Magne; Oltedal, Leif; Erchinger, Vera Jane; Ødegaard, Ketil Joachim; Haavik, Jan; Kessler, Ute (Peer reviewed; Journal article, 2019-05-31)
      Background: Prior studies suggest that activation of the tryptophan catabolism via the kynurenine pathway by proinflammatory cytokines may be involved in the pathophysiology of depression. Electroconvulsive therapy (ECT) ...
    • Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial 

      Bratlie, Marianne; Hagen, Ingrid Valheim; Helland, Anita; Erchinger, Friedemann Georg; Midttun, Øivind; Ueland, Per Magne; Rosenlund, Grethe; Sveier, Harald; Mellgren, Gunnar; Hausken, Trygve; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2020-10-27)
      Purpose To explore whether high intake of cod or salmon would affect gut microbiota profile, faecal output and serum concentrations of lipids and bile acids. Methods Seventy-six adults with overweight/obesity with no ...
    • Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults 

      Zahed, Hana; Johansson, Mattias; Ueland, Per Magne; Midttun, Øivind; Milne, Roger L.; Giles, Graham G.; Manjer, Jonas; Sandsveden, Malte; Langhammer, Arnulf; Sørgjerd, Elin Pettersen; Grankvist, Kjell; Johansson, Mikael; Freedman, Neal D.; Huang, Wen-Yi; Chen, Chu; Prentice, Ross; Stevens, Victoria L.; Wang, Ying; Le Marchand, Loic; Wilkens, Lynne R.; Weinstein, Stephanie J.; Albanes, Demetrius; Cai, Qiuyin; Blot, William J.; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Shu, Xiao-Ou; Zheng, Wei; Yuan, Jian-Min; Koh, Woon-Puay; Visvanathan, Kala; Sesso, Howard D.; Zhang, Xuehong; Gaziano, J. Michael; Fanidi, Anouar; Muller, David; Brennan, Paul; Guida, Florence; Robbins, Hilary A. (Journal article; Peer reviewed, 2021)
      Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin ...