Browsing Bergen Open Research Archive by Author "Migaud, Marie E."

Now showing items 1-5 of 5

    • Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells 

      Kulikova, Veronika; Shabalin, Konstantin; Nerinovski, Kirill; Yakimov, Alexander; Svetlova, Maria; Solovjeva, Ljudmila; Kropotov, Andrey; Khodorkovskiy, Mikhail; Migaud, Marie E.; Ziegler, Mathias; Nikiforov, Andrey (Peer reviewed; Journal article, 2019-11-29)
      Nicotinamide adenine dinucleotide (NAD) is an essential redox carrier, whereas its degradation is a key element of important signaling pathways. Human cells replenish their NAD contents through NAD biosynthesis from ...

    • Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD 

      Sverkeli, Lars Jansen; Hayat, Faisal; Migaud, Marie E.; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is ...

    • Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells 

      Kropotov, Andrey; Kulikova, Veronika; Nerinovski, Kirill; Yakimov, Alexander; Svetlova, Maria; Solovjeva, Ljudmila; Sudnitsyna, Julia; Migaud, Marie E.; Khodorkovskiy, Mikhail; Ziegler, Mathias; Nikiforov, Andrey (Journal article; Peer reviewed, 2021)
      Nicotinamide riboside (NR), a new form of vitamin B3, is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in human and animal cells. The introduction of NR into the body effectively increases the level ...

    • Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells 

      Kropotov, Andrey; Kulikova, Veronika; Solovjeva, Ljudmila; Yakimov, Alexander; Nerinovski, Kirill; Svetlova, Maria; Sudnitsyna, Julia; Plusnina, Alena; Antipova, Maria; Khodorkovskiy, Mikhail; Migaud, Marie E.; Gambaryan, Stepan; Ziegler, Mathias; Nikiforov, Andrey (Journal article; Peer reviewed, 2022)
      Nicotinamide riboside (NR) is an effective precursor of nicotinamide adenine dinucleotide (NAD) in human and animal cells. NR supplementation can increase the level of NAD in various tissues and thereby improve physiological ...

    • SLC25A51 is a mammalian mitochondrial NAD+ transporter 

      Luongo, Timothy S.; Eller, Jared M.; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R.; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R.; Migaud, Marie E.; Rabinowitz, Joshua D.; Johnson, F. Brad; Johnsson, Kai; Ziegler, Mathias; Cambronne, Xiaolu A.; Baur, Joseph A. (Journal article; Peer reviewed, 2020)
      Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in ...