Blar i Bergen Open Research Archive på forfatter "Mohamed-Ahmed, Samih Salah Eldin Mahgoub"
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Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds
Jenssen, Astrid Bjørke; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kankuri, Esko; Brekke, Ragnvald Ljones; Guttormsen, Anne Berit; Gjertsen, Bjørn Tore; Mustafa, Kamal Babikeir Elnour; Almeland, Stian Kreken (Journal article; Peer reviewed, 2022)Cellular therapies for burn wound healing, including the administration of mesenchymal stem or stromal cells (MSCs), have shown promising results. This review aims to provide an overview of the current administration methods ... -
Bone regeneration in rat calvarial defects using dissociated or spheroid mesenchymal stromal cells in scaffold-hydrogel constructs
Shanbhag, Siddharth; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kampleitner, Carina; Hassan, Mohamed Nageeb; Heimel, Patrick; Dobsak, Toni; Tangl, Stefan; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)Background Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D printing offers the possibility to produce customized scaffolds for complex ... -
Brief communication: Effects of conditioned media from human platelet lysate cultured MSC on osteogenic cell differentiation in vitro
Shanbhag, Siddharth; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Gruber, Reinhard; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)Culturing mesenchymal stromal cells (MSC) in human platelet lysate (HPL) supplemented media can enhance their osteogenic differentiation potential. The objective of this study was to test the hypothesis that conditioned ... -
Conditioned Medium from Bone Marrow Mesenchymal Stem Cells Restored Oxidative Stress-Related Impaired Osteogenic Differentiation
Saleem, Ragda; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Elnour, Rammah; Berggreen, Ellen; Mustafa, Kamal Babikeir Elnour; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid (Journal article; Peer reviewed, 2021)Oxidative stress from high levels of intracellular reactive oxygen species (ROS) has been linked to various bone diseases. Previous studies indicate that mesenchymal stem cells (MSC) secrete bioactive factors (conditioned ... -
Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate)
Hassan, Mohamad Nageeb Abdelaziz; Yassin, Mohammed Ahmed; Eltawila, Ahmed Maher; Aladawi, Ahmed Emad; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Suliman, Salwa; Kandil, Sherif; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)Background To support bone regeneration, 3D-printed templates function as temporary guides. The preferred materials are synthetic polymers, due to their ease of processing and biological inertness. Poly(lactide-co-trimethylene ... -
Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs
Shanbhag, Siddharth; Kampleitner, Carina; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Yassin, Mohammed Ahmed Alamin Yousif; Dongre, Harsh Nitin; Costea, Daniela Elena; Tangl, Stefan; Stavropoulos, Andreas; Bolstad, Anne Isine; Suliman, Salwa; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021-11-30)Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation and bone regeneration capacity of mesenchymal stromal cells (MSC). Gingiva-derived progenitor cells (GPC) represent a less invasive alternative ... -
Functionalizing Collagen Membranes with MSC-Conditioned Media Promotes Guided Bone Regeneration in Rat Calvarial Defects
Shanbhag, Siddharth; Kampleitner, Carina; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Apaza Alccayhuaman, Karol Ali; Heimel, Patrick; Tangl, Stefan; Beinlich, Andreas Michael; Rana, Neha; Sanz, Mariano; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Gruber, Reinhard (Journal article; Peer reviewed, 2023-02-28)Functionalizing biomaterials with conditioned media (CM) from mesenchymal stromal cells (MSC) is a promising strategy for enhancing the outcomes of guided bone regeneration (GBR). This study aimed to evaluate the bone ... -
Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration
Suliman, Salwa; Mieszkowska, Anna; Folkert, Justyna; Rana, Neha; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fuoco, Tiziana; Finne-Wistrand, Anna; Dirscherl, Kai; Jørgensen, Bodil; Mustafa, Kamal Babikeir Elnour; Gurzawska-Comis, Katarzyna (Journal article; Peer reviewed, 2022)Background Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly ... -
The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination
Kråkenes, Torbjørn; Wergeland, Stig; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fromreide, Siren; Costea, Daniela Elena; Mustafa, Kamal Babikeir Elnour; Bø, Lars; Kvistad, Christopher Elnan (Journal article; Peer reviewed, 2023)Introduction Multiple sclerosis (MS) is characterized by chronic inflammation, demyelination, and axonal degeneration within the central nervous system (CNS), for which there is no current treatment available with the ... -
Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin
Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Gruber, Reinhard; Sanz, Mariano; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Shanbhag, Siddharth (Journal article; Peer reviewed, 2023)Secretomes of mesenchymal stromal cells (MSCs) are emerging as a novel growth factor (GF)-based strategy for periodontal and bone regeneration. The objective of this study was to compare the secretome of human bone marrow ... -
Understanding of how the properties of medical grade lactide based copolymer scaffolds influence adipose tissue regeneration: Sterilization and a systematic in vitro assessment
Jain, Shubham; Yassin, Mohammed Ahmed Alamin Yousif; Fuoco, Tiziana; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Vindenes, Hallvard; Mustafa, Kamal Babikeir Elnour; Finne-Wistand, Anna (Journal article; Peer reviewed, 2021)Aliphatic polyesters are the synthetic polymers most commonly used in the development of resorbable medical implants/devices. Various three-dimensional (3D) scaffolds have been fabricated from these polymers and used in ...