Browsing Bergen Open Research Archive by Author "Mustafa, Kamal Babikeir Elnour"
Now showing items 1-20 of 28
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Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds
Jenssen, Astrid Bjørke; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kankuri, Esko; Brekke, Ragnvald Ljones; Guttormsen, Anne Berit; Gjertsen, Bjørn Tore; Mustafa, Kamal Babikeir Elnour; Almeland, Stian Kreken (Journal article; Peer reviewed, 2022)Cellular therapies for burn wound healing, including the administration of mesenchymal stem or stromal cells (MSCs), have shown promising results. This review aims to provide an overview of the current administration methods ... -
Biomimetic Highly Porous Nanocellulose-Nanohydroxyapatite Scaffolds for Bone Tissue Engineering
Korkeamäki, Jannika Timontytär; Rashad, Ahmad; Berstad, Kaia; Weber, Florian; Syverud, Kristin; Haugen, Håvard Jostein; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2024)Wood-derived TEMPO-oxidized cellulose nanofibrils (CNFs) have potential as scaffolding for bone tissue engineering. Although biocompatible, the material lacks osteoconductive and appropriate mechanical properties. Incorporation ... -
Bone regeneration in rat calvarial defects using dissociated or spheroid mesenchymal stromal cells in scaffold-hydrogel constructs
Shanbhag, Siddharth; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kampleitner, Carina; Hassan, Mohamed Nageeb; Heimel, Patrick; Dobsak, Toni; Tangl, Stefan; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)Background Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D printing offers the possibility to produce customized scaffolds for complex ... -
Brief communication: Effects of conditioned media from human platelet lysate cultured MSC on osteogenic cell differentiation in vitro
Shanbhag, Siddharth; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Gruber, Reinhard; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)Culturing mesenchymal stromal cells (MSC) in human platelet lysate (HPL) supplemented media can enhance their osteogenic differentiation potential. The objective of this study was to test the hypothesis that conditioned ... -
Conditioned Medium from Bone Marrow Mesenchymal Stem Cells Restored Oxidative Stress-Related Impaired Osteogenic Differentiation
Saleem, Ragda; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Elnour, Rammah; Berggreen, Ellen; Mustafa, Kamal Babikeir Elnour; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid (Journal article; Peer reviewed, 2021)Oxidative stress from high levels of intracellular reactive oxygen species (ROS) has been linked to various bone diseases. Previous studies indicate that mesenchymal stem cells (MSC) secrete bioactive factors (conditioned ... -
Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate)
Hassan, Mohamad Nageeb Abdelaziz; Yassin, Mohammed Ahmed; Eltawila, Ahmed Maher; Aladawi, Ahmed Emad; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Suliman, Salwa; Kandil, Sherif; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)Background To support bone regeneration, 3D-printed templates function as temporary guides. The preferred materials are synthetic polymers, due to their ease of processing and biological inertness. Poly(lactide-co-trimethylene ... -
Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs
Shanbhag, Siddharth; Kampleitner, Carina; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Yassin, Mohammed Ahmed Alamin Yousif; Dongre, Harsh Nitin; Costea, Daniela Elena; Tangl, Stefan; Stavropoulos, Andreas; Bolstad, Anne Isine; Suliman, Salwa; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021-11-30)Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation and bone regeneration capacity of mesenchymal stromal cells (MSC). Gingiva-derived progenitor cells (GPC) represent a less invasive alternative ... -
The effect of resolvin D1 on bone regeneration in a rat calvarial defect model
Jiang, Xiaofeng; Liu, Jing; Li, Si; Qiu, Yingfei; Wang, Xiaoli; He, Xiaoli; Pedersen, Torbjørn Østvik; Mustafa, Kamal Babikeir Elnour; Xue, Ying; Mustafa, Manal; Kantarci, Alpdogan; Xing, Zhe (Journal article; Peer reviewed, 2022)Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose of this study was to investigate the effect of RvD1 on bone regeneration using ... -
Efficacy of treating segmental bone defects through endochondral ossification: 3D printed designs and bone metabolic activities
Hara, Kenji; Hellem, Endre; Yamada, Shuntaro; Sariibrahimoglu, Kemal; Mølster, Anders; Gjerdet, Nils Roar; Hellem, Sølve; Mustafa, Kamal Babikeir Elnour; Yassin, Mohammed Ahmed Alamin Yousif (Journal article; Peer reviewed, 2022)Three-dimensional printing (3D printing) is a promising technique for producing scaffolds for bone tissue engineering applications. Porous scaffolds can be printed directly, and the design, shape and porosity can be ... -
Endochondral Ossification Induced by Cell Transplantation of Endothelial Cells and Bone Marrow Stromal Cells with Copolymer Scaffold Using a Rat Calvarial Defect Model
Xing, Zhe; Jiang, Xiaofeng; Si, Qingzong; Finne-Wistrand, Anna; Liu, Bin; Xue, Ying; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)It has been recently reported that, in a rat calvarial defect model, adding endothelial cells (ECs) to a culture of bone marrow stromal cells (BMSCs) significantly enhanced bone formation. The aim of this study is to further ... -
Extracellular Vesicles Derived from Primed Mesenchymal Stromal Cells Loaded on Biphasic Calcium Phosphate Biomaterial Exhibit Enhanced Macrophage Polarization
Rana, Neha; Suliman, Salwa; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)Mesenchymal stromal cells (MSC) loaded on biphasic calcium phosphate biomaterial (MSC + BCP) have been used as an advanced therapy medicinal product to treat complex maxillofacial bone defects in patients. Further, MSC-derived ... -
Functionalizing Collagen Membranes with MSC-Conditioned Media Promotes Guided Bone Regeneration in Rat Calvarial Defects
Shanbhag, Siddharth; Kampleitner, Carina; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Apaza Alccayhuaman, Karol Ali; Heimel, Patrick; Tangl, Stefan; Beinlich, Andreas Michael; Rana, Neha; Sanz, Mariano; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Gruber, Reinhard (Journal article; Peer reviewed, 2023-02-28)Functionalizing biomaterials with conditioned media (CM) from mesenchymal stromal cells (MSC) is a promising strategy for enhancing the outcomes of guided bone regeneration (GBR). This study aimed to evaluate the bone ... -
Hybrid material based on hyaluronan hydrogels and poly(l-lactide-co-1,3-trimethylene carbonate) scaffolds toward a cell-instructive microenvironment with long-term in vivo degradability
Kivijärvi, Tove; Goksøyr, Øyvind; Yassin, Mohammed Ahmed Alamin Yousif; Jain, Shubham; Yamada, Shuntaro; Mustafa, Kamal Babikeir Elnour; Finne-Wistranda, Anna (Journal article; Peer reviewed, 2022)Degradable polyester-based scaffolds are ideal for tissue engineering applications where long-term structural integrity and mechanical support are a requisite. However, their hydrophobic and unfunctionalized surfaces ... -
Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration
Suliman, Salwa; Mieszkowska, Anna; Folkert, Justyna; Rana, Neha; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fuoco, Tiziana; Finne-Wistrand, Anna; Dirscherl, Kai; Jørgensen, Bodil; Mustafa, Kamal Babikeir Elnour; Gurzawska-Comis, Katarzyna (Journal article; Peer reviewed, 2022)Background Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly ... -
In-Silico Prediction of Mechanical Behaviour of Uniform Gyroid Scaffolds Affected by Its Design Parameters for Bone Tissue Engineering Applications
Nazimutheen Musthafa, Haja Sherief; Walker, Jason; Rahman, Talal; Bjørkum, Alvhild Alette; Mustafa, Kamal Babikeir Elnour; Velauthapillai, Dhayalan (Journal article; Peer reviewed, 2023)Due to their excellent properties, triply periodic minimal surfaces (TPMS) have been applied to design scaffolds for bone tissue engineering applications. Predicting the mechanical response of bone scaffolds in different ... -
Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor
Yamada, Shuntaro; Yassin, Mohammed Ahmed; Schwarz, Thomas; Hansmann, Jan; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)The fatal determination of bone marrow mesenchymal stem/stromal cells (BMSC) is closely associated with mechano-environmental factors in addition to biochemical clues. The aim of this study was to induce osteogenesis in ... -
Influence of Bone Substitutes on Mesenchymal Stromal Cells in an Inflammatory Microenvironment
Shanbhag, Siddharth; Rana, Neha; Suliman, Salwa; Idris, Shaza Bushra Mohamed; Mustafa, Kamal Babikeir Elnour; Stavropoulos, Andreas (Journal article; Peer reviewed, 2022)Bone regeneration is driven by mesenchymal stromal cells (MSCs) via their interactions with immune cells, such as macrophages (MPs). Bone substitutes, e.g., bi-calcium phosphates (BCPs), are commonly used to treat bone ... -
The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination
Kråkenes, Torbjørn; Wergeland, Stig; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fromreide, Siren; Costea, Daniela Elena; Mustafa, Kamal Babikeir Elnour; Bø, Lars; Kvistad, Christopher Elnan (Journal article; Peer reviewed, 2023)Introduction Multiple sclerosis (MS) is characterized by chronic inflammation, demyelination, and axonal degeneration within the central nervous system (CNS), for which there is no current treatment available with the ... -
Optimisation and validation of a custom-designed perfusion bioreactor for bone tissue engineering: Flow assessment and optimal culture environmental conditions
Yamada, Shuntaro; Yassin, Mohammed Ahmed Alamin Yousif; Schwarz, Thomas; Mustafa, Kamal Babikeir Elnour; Hansmann, Jan (Journal article; Peer reviewed, 2022)Various perfusion bioreactor systems have been designed to improve cell culture with three-dimensional porous scaffolds, and there is some evidence that fluid force improves the osteogenic commitment of the progenitors. ... -
Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin
Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Gruber, Reinhard; Sanz, Mariano; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Shanbhag, Siddharth (Journal article; Peer reviewed, 2023)Secretomes of mesenchymal stromal cells (MSCs) are emerging as a novel growth factor (GF)-based strategy for periodontal and bone regeneration. The objective of this study was to compare the secretome of human bone marrow ...