• Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy 

      Erchinger, Vera Jane; Miller, Jeremy; Jones, Thomas; Kessler, Ute; Bustillo, Juan R.; Haavik, Jan; Petrillo, Jonathan; Ziomek, Gregory; Hammar, Åsa; Ødegaard, Ketil Joachim; Calhoun, Vince D.; McClintock, Shawn M.; Ersland, Lars; Oltedal, Leif; Abbott, Christopher (Journal article; Peer reviewed, 2020-09-17)
      Objective The anticonvulsant hypothesis posits that ECT’s mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory ...
    • Brain changes induced by electroconvulsive therapy are broadly distributed 

      Ousdal, Olga Therese; Argyelan, Miklos; Narr, Katherine L.; Abbott, Christopher; Wade, Benjamin; Vandenbulcke, Mathieu; Urretavizcaya, Mikel; Tendolkar, Indira; Takamiya, Akihiro; Stek, Max L.; Soriano-Mas, Carles; Redlich, Ronny; Paulson, Olaf B.; Oudega, Mardien L.; Opel, Nils; Nordanskog, Pia; Kishimoto, Taishiro; Kämpe, Robin; Jørgensen, Anders; Hanson, Lars G.; Hamilton, J. Paul; Espinoza, Randall; Emsell, Louise; van Eijndhoven, Philip; Dols, Annemieke; Dannlowski, Udo; Cardoner, Narcis; Bouckaert, Filip; Anand, Amit; Bartsch, Hauke; Kessler, Ute; Ødegaard, Ketil Joachim; Dale, Anders; Oltedal, Leif (Peer reviewed; Journal article, 2020-03-01)
      Background Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we ...
    • The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites 

      Aarsland, Tore Ivar Malmei; Leskauskaite, Ieva; Midttun, Øivind; Ulvik, Arve; Ueland, Per Magne; Oltedal, Leif; Erchinger, Vera Jane; Ødegaard, Ketil Joachim; Haavik, Jan; Kessler, Ute (Peer reviewed; Journal article, 2019-05-31)
      Background: Prior studies suggest that activation of the tryptophan catabolism via the kynurenine pathway by proinflammatory cytokines may be involved in the pathophysiology of depression. Electroconvulsive therapy (ECT) ...
    • Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function 

      Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-05-01)
      Background Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ...
    • Electric field causes volumetric changes in the human brain 

      Argyelan, Miklos; Oltedal, Leif; Deng, Zhi-De; Wade, Benjamin; Bikson, Marom; Joanlanne, Andrea; Sanghani, Sohag; Bartsch, Hauke; Cano, Marta; Dale, Anders M.; Dannlowski, Udo; Dols, Annemieke; Enneking, Verena; Espinoza, Randall; Kessler, Ute; Narr, Katherine L.; Ødegaard, Ketil Joachim; Oudega, Mardien L.; Redlich, Ronny; Stek, Max L.; Takamiya, Akihiro; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Pujol, Jesus; Tendolkar, Indira; van Eijndhoven, Philip; Petrides, Georgios; Malhotra, Anil K.; Abbott, Christopher (Peer reviewed; Journal article, 2019)
      Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used ...
    • Magnetic Resonance Spectroscopy in Depressed Subjects Treated With Electroconvulsive Therapy—A Systematic Review of Literature 

      Erchinger, Vera Jane; Ersland, Lars; Aukland, Stein Magnus; Abbott, Christopher; Oltedal, Leif (Journal article; Peer reviewed, 2021)
      Electroconvulsive therapy (ECT) is considered to be the most effective acute treatment for otherwise treatment resistant major depressive episodes, and has been used for over 80 years. Still, the underlying mechanism of ...
    • Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative 

      Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank (Peer reviewed; Journal article, 2019-09-25)
      Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...
    • Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study 

      Rahman, Mohummad Aminur; Brekke, Jorunn; Arnesen, Victoria Smith; Hannisdal, Marianne; Navarro, Andrea Gras; Waha, Andreas; Herfindal, Lars; Rygh, Cecilie Brekke; Bratland, Eirik; Brandal, Petter; Haász, Judit; Oltedal, Leif; Miletic, Hrvoje; Lundervold, Arvid; Lie, Stein Atle; Goplen, Dorota; Chekenya, Martha (Journal article; Peer reviewed, 2020)
      Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ...
    • Structural changes induced by electroconvulsive therapy are associated with clinical outcome 

      Mulders, Peter C. R.; Llera, Alberto; Beckmann, Christian F.; Vandenbulcke, Mathieu; Stek, Max L; Sienaert, Pascal; Redlich, Ronny; Petrides, Georgios; Oudega, Mardien L.; Oltedal, Leif; Ødegaard, Ketil Joachim; Narr, Katherine L; Magnusson, Peter; Kessler, Ute; Jorgensen, Anders; Espinoza, Randall; Enneking, Verena; Emsell, Louise; Dols, Annemieke; Dannlowski, Udo; Bolwig, Tom G; Bartsch, Hauke; Argyelan, Miklos; Anand, Amit; Abbott, Christopher; van Eijndhoven, Philip; Tendolkar, Indira (Journal article; Peer reviewed, 2020)
      Background Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and ...