Blar i Bergen Open Research Archive på forfatter "Oltedal, Leif"

Viser treff 1-20 av 20

    • Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy 

      Wade, Benjamin; Hellemann, Gerhard S.; Espinoza, Randall; Woods, Roger P.; Joshi, Shantanu H.; Redlich, Ronny; Dannlowski, Udo; Jorgensen, Anders; Abbott, Christopher; Oltedal, Leif; Narr, Katherine L. (Journal article; Peer reviewed, 2021)
      Depression symptom heterogeneity limits the identifiability of treatment-response biomarkers. Whether improvement along dimensions of depressive symptoms relates to separable neural networks remains poorly understood. We ...

    • Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy 

      Erchinger, Vera Jane; Miller, Jeremy; Jones, Thomas; Kessler, Ute; Bustillo, Juan R.; Haavik, Jan; Petrillo, Jonathan; Ziomek, Gregory; Hammar, Åsa; Ødegaard, Ketil Joachim; Calhoun, Vince D.; McClintock, Shawn M.; Ersland, Lars; Oltedal, Leif; Abbott, Christopher (Journal article; Peer reviewed, 2020-09-17)
      Objective The anticonvulsant hypothesis posits that ECT’s mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory ...

    • Brain changes induced by electroconvulsive therapy are broadly distributed 

      Ousdal, Olga Therese; Argyelan, Miklos; Narr, Katherine L.; Abbott, Christopher; Wade, Benjamin; Vandenbulcke, Mathieu; Urretavizcaya, Mikel; Tendolkar, Indira; Takamiya, Akihiro; Stek, Max L.; Soriano-Mas, Carles; Redlich, Ronny; Paulson, Olaf B.; Oudega, Mardien L.; Opel, Nils; Nordanskog, Pia; Kishimoto, Taishiro; Kämpe, Robin; Jørgensen, Anders; Hanson, Lars G.; Hamilton, J. Paul; Espinoza, Randall; Emsell, Louise; van Eijndhoven, Philip; Dols, Annemieke; Dannlowski, Udo; Cardoner, Narcis; Bouckaert, Filip; Anand, Amit; Bartsch, Hauke; Kessler, Ute; Ødegaard, Ketil Joachim; Dale, Anders; Oltedal, Leif (Peer reviewed; Journal article, 2020-03-01)
      Background Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we ...

    • Development and validation of a multimodal neuroimaging biomarker for electroconvulsive therapy outcome in depression: A multicenter machine learning analysis 

      Bruin, Willem Benjamin; Oltedal, Leif; Bartsch, Hauke; Abbott, Christopher; Argyelan, Miklos; Barbour, Tracy; Camprodon, Joan; Chowdhury, Samadrita; Espinoza, Randall; Mulders, Peter; Narr, Katherine; Oudega, Mardien; Rhebergen, Didi; Ten Doesschate, Freek; Tendolkar, Indira; Van Eijndhoven, Philip; Van Exel, Eric; Van Verseveld, Mike; Wade, Benjamin; Van Waarde, Jeroen; Zhutovsky, Paul; Dols, Annemiek; Van Wingen, Guido (Journal article; Peer reviewed, 2023)
      Background Electroconvulsive therapy (ECT) is the most effective intervention for patients with treatment resistant depression. A clinical decision support tool could guide patient selection to improve the overall ...

    • The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites 

      Aarsland, Tore Ivar Malmei; Leskauskaite, Ieva; Midttun, Øivind; Ulvik, Arve; Ueland, Per Magne; Oltedal, Leif; Erchinger, Vera Jane; Ødegaard, Ketil Joachim; Haavik, Jan; Kessler, Ute (Peer reviewed; Journal article, 2019-05-31)
      Background: Prior studies suggest that activation of the tryptophan catabolism via the kynurenine pathway by proinflammatory cytokines may be involved in the pathophysiology of depression. Electroconvulsive therapy (ECT) ...

    • Effective resting-state connectivity in severe unipolar depression before and after electroconvulsive therapy 

      ten Doesschate, Freek; Bruin, Willem; Zeidman, Peter; Abbott, Christopher C.; Argyelan, Miklos; Dols, Annemieke; Emsell, Louise; van Eijndhoven, Philip F.P.; van Exel, Eric; Mulders, Peter C.R.; Narr, Katherine; Tendolkar, Indira; Rhebergen, Didi; Sienaert, Pascal; Vandenbulcke, Mathieu; Verdijk, Joey; van Verseveld, Mike; Bartsch, Hauke; Oltedal, Leif; van Waarde, Jeroen A.; van Wingen, Guido A. (Journal article; Peer reviewed, 2023)
      Background Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depressive disorders. A recent multi-center study found no consistent changes in correlation-based (undirected) resting-state ...

    • Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function 

      Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-05-01)
      Background Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ...

    • Electric field causes volumetric changes in the human brain 

      Argyelan, Miklos; Oltedal, Leif; Deng, Zhi-De; Wade, Benjamin; Bikson, Marom; Joanlanne, Andrea; Sanghani, Sohag; Bartsch, Hauke; Cano, Marta; Dale, Anders M.; Dannlowski, Udo; Dols, Annemieke; Enneking, Verena; Espinoza, Randall; Kessler, Ute; Narr, Katherine L.; Ødegaard, Ketil Joachim; Oudega, Mardien L.; Redlich, Ronny; Stek, Max L.; Takamiya, Akihiro; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Pujol, Jesus; Tendolkar, Indira; van Eijndhoven, Philip; Petrides, Georgios; Malhotra, Anil K.; Abbott, Christopher (Peer reviewed; Journal article, 2019)
      Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used ...

    • Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate 

      Erchinger, Vera Jane; Craven, Alexander R.; Ersland, Lars; Oedegaard, Ketil J.; Bartz-Johannessen, Christoffer; Hammar, Åsa Karin; Haavik, Jan; Riemer, Frank; Kessler, Ute; Oltedal, Leif (Journal article; Peer reviewed, 2023)
      Introduction: Based on previous research on electroconvulsive therapy (ECT) we have proposed a model where disruption, potentiation, and rewiring of brain networks occur in sequence and serve as the underlying therapeutic ...

    • Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression 

      Argyelan, Miklos; Deng, Zhi-De; Ousdal, Olga Therese; Oltedal, Leif; Angulo, Brian; Baradits, Mate; Spitzberg, Andrew J.; Kessler, Ute; Sartorius, Alexander; Dols, Annemiek; Narr, Katherine L.; Espinoza, Randall; van Waarde, Jeroen A.; Tendolkar, Indira; van Eijndhoven, Philip; van Wingen, Guido A.; Takamiya, Akihiro; Kishimoto, Taishiro; Jorgensen, Martin B.; Jorgensen, Anders; Paulson, Olaf B.; Yrondi, Antoine; Péran, Patrice; Soriano-Mas, Carles; Cardoner, Narcis; Cano, Marta; van Diermen, Linda; Schrijvers, Didier; Belge, Jean-Baptiste; Emsell, Louise; Bouckaert, Filip; Vandenbulcke, Mathieu; Kiebs, Maximilian; Hurlemann, René; Mulders, Peter Cr.; Redlich, Ronny; Dannlowski, Udo; Erhan, Kavakbasi; Kritzer, Michael D.; Ellard, Kristen K.; Camprodon, Joan A.; Petrides, Georgios; Malhotra, Anil K.; Abbott, Christopher C. (Journal article; Peer reviewed, 2023)
      Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, ...

    • Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy 

      Opel, Nils; Narr, Katherine L; Abbott, Christopher; Argyelan, Miklos; Espinoza, Randall; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Vandenbulcke, Mathieu; Nordanskog, Pia; Repple, Jonathan; Kavakbasi, Erhan; Jorgensen, Martin B.; Paulson, Olaf B.; Hanson, Lars G.; Dols, Annemieke; van Exel, Eric; Oudega, Mardien L.; Takamiya, Akihiro; Kishimoto, Taishiro; Ousdal, Olga Therese; Haavik, Jan; Hammar, Åsa Karin; Ødegaard, Ketil Joachim; Kessler, Ute; Bartsch, Hauke; Dale, Anders M.; Baune, Bernhard T; Dannlowski, Udo; Oltedal, Leif; Redlich, Ronny (Journal article; Peer reviewed, 2021)
      Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive ...

    • Feasibility of deep learning-based tumor segmentation for target delineation and response assessment in grade-4 glioma using multi-parametric MRI 

      Hannisdal, Marianne Hjellvik; Goplen, Dorota; Alam, Saruar; Haász, Judit; Oltedal, Leif; Rahman, Mohummad Aminur; Rygh, Cecilie Brekke; Lie, Stein Atle; Lundervold, Arvid; Enger, Martha (Journal article; Peer reviewed, 2023)
      Background Tumor burden assessment is essential for radiation therapy (RT), treatment response evaluation, and clinical decision-making. However, manual tumor delineation remains laborious and challenging due to ...

    • Magnetic Resonance Spectroscopy in Depressed Subjects Treated With Electroconvulsive Therapy—A Systematic Review of Literature 

      Erchinger, Vera Jane; Ersland, Lars; Aukland, Stein Magnus; Abbott, Christopher; Oltedal, Leif (Journal article; Peer reviewed, 2021)
      Electroconvulsive therapy (ECT) is considered to be the most effective acute treatment for otherwise treatment resistant major depressive episodes, and has been used for over 80 years. Still, the underlying mechanism of ...

    • Multimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes 

      van de Mortel, L.A.; Bruin, W.B.; Thomas, R.M.; Abbott, C.; Argyelan, M.; van Eijndhoven, P.; Mulders, P.; Narr, K.L.; Tendolkar, I.; Verdijk, J.P.A.J.; van Waarde, J.A.; Bartsch, Hauke; Oltedal, Leif; van Wingen, G.A. (Journal article; Peer reviewed, 2022)
      Background: Electroconvulsive therapy (ECT) is an effective treatment for severe depression and induces gray matter (GM) increases in the brain. Small-scale studies suggest that ECT also leads to changes in brain functioning, ...

    • Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration 

      Takamiya, Akihiro; Dols, Annemiek; Emsell, Louise; Abbott, Christopher; Yrondi, Antoine; Soriano-Mas, Carles; Jørgensen, Martin Balslev; Nordanskog, Pia; Rhebergen, Didi; van Exel, Eric; Oudega, Mardien L.; Bouckaert, Filip; Vandenbulcke, Mathieu; Sienaert, Pascal; Péran, Patrice; Cano, Marta; Cardoner, Narcis; Jørgensen, Anders; Paulson, Olaf B.; Hamilton, Paul; Kampe, Robin; Bruin, Willem; Bartsch, Hauke; Ousdal, Olga Therese; Kessler, Ute; van Wingen, Guido; Oltedal, Leif; Kishimoto, Taishiro (Journal article; Peer reviewed, 2021)
      Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to ...

    • The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go? 

      Ousdal, Olga Therese; Brancati, Giulio E.; Kessler, Ute; Erchinger, Vera; Dale, Anders M.; Abbott, Christopher; Oltedal, Leif (Journal article; Peer reviewed, 2021)
      Electroconvulsive therapy (ECT) is an established treatment choice for severe, treatment-resistant depression, yet its mechanisms of action remain elusive. Magnetic resonance imaging (MRI) of the human brain before and ...

    • Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative 

      Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank (Peer reviewed; Journal article, 2019-09-25)
      Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...

    • Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study 

      Rahman, Mohummad Aminur; Brekke, Jorunn; Arnesen, Victoria Smith; Hannisdal, Marianne; Navarro, Andrea Gras; Waha, Andreas; Herfindal, Lars; Rygh, Cecilie Brekke; Bratland, Eirik; Brandal, Petter; Haász, Judit; Oltedal, Leif; Miletic, Hrvoje; Lundervold, Arvid; Lie, Stein Atle; Goplen, Dorota; Chekenya, Martha (Journal article; Peer reviewed, 2020)
      Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ...

    • Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes 

      Brancati, Giulio Emilio; Brekke, Njål; Bartsch, Hauke; Sørhaug, Ole Johan Evjenth; Ousdal, Olga Therese; Hammar, Åsa Karin; Schuster, Peter Moritz; Ødegaard, Ketil Joachim; Kessler, Ute; Oltedal, Leif (Journal article; Peer reviewed, 2021)
      Background: Electroconvulsive therapy (ECT) has been shown to induce broadly distributed cortical and subcortical volume increases, more prominently in the amygdala and the hippocampus. Structural changes after one ECT ...

    • Structural changes induced by electroconvulsive therapy are associated with clinical outcome 

      Mulders, Peter C. R.; Llera, Alberto; Beckmann, Christian F.; Vandenbulcke, Mathieu; Stek, Max L; Sienaert, Pascal; Redlich, Ronny; Petrides, Georgios; Oudega, Mardien L.; Oltedal, Leif; Ødegaard, Ketil Joachim; Narr, Katherine L; Magnusson, Peter; Kessler, Ute; Jorgensen, Anders; Espinoza, Randall; Enneking, Verena; Emsell, Louise; Dols, Annemieke; Dannlowski, Udo; Bolwig, Tom G; Bartsch, Hauke; Argyelan, Miklos; Anand, Amit; Abbott, Christopher; van Eijndhoven, Philip; Tendolkar, Indira (Journal article; Peer reviewed, 2020)
      Background Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and ...