• Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice 

      Svärd, Jessica; Røst, Therese Halvorsen; Sommervoll, Camilla Elise Nergård; Haugen, Christine; Gudbrandsen, Oddrun Anita; Christensen, Anne Elisabeth; Rødahl, Eyvind; Fernø, Johan; Dankel, Simon N; Sagen, Jørn V.; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Studies have implicated the extracellular matrix (ECM) of adipose tissue in insulin resistance. The proteoglycan decorin, a component of ECM, has been associated with glucose tolerance, but possible causal effects on ...
    • Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery 

      Christensen, Monika; Fadnes, Dag Jone Stokke; Røst, Therese Halvorsen; Pedersen, Eva Ringdal; Andersen, John Roger; Våge, Villy; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Nygård, Ottar; Mellgren, Gunnar (Peer reviewed; Journal article, 2018-02-05)
      Objective: Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio ...
    • Peroxisome proliferator-activated receptors (PPARs) and mitochondria in relation to lifestyle-related diseases 

      Røst, Therese Halvorsen (Doctoral thesis, 2008-06-17)
      Obesity is a growing life-style related health problem, and is often accompanied by dyslipidemia, insulin resistance and inflammation. This may in turn lead to hyperinsulinemia, increased risk of non-alcoholic fatty liver ...
    • The Rho GTPase RND3 regulates adipocyte lipolysis 

      Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte ...
    • Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer 

      Moi, Line Leonora Haugan; Flågeng, Marianne Hauglid; Gjerde, Jennifer; Madsen, Andre; Røst, Therese Halvorsen; Gudbrandsen, Oddrun Anita; Lien, Ernst Asbjørn; Mellgren, Gunnar (Peer reviewed; Journal article, 2012-06-15)
      Background: Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling ...