Browsing Bergen Open Research Archive by Author "Rongved, Pål"
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Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles
Prandina, Anthony; Herfindal, Lars; Radix, S; Rongved, Pål; Doskeland, Stein Ove; Le Borgne, Marc; Perret, F (Journal article; Peer reviewed, 2018)Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. ... -
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ...