• Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation 

      Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Maeland, Steffen; O'Connell, Kevin S.; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Dale, Anders (Peer reviewed; Journal article, 2019-06-03)
      Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, ...
    • Common brain disorders are associated with heritable patterns of apparent aging of the brain 

      Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2019)
      Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data ...
    • Discovery of shared genomic loci using the conditional false discovery rate approach 

      Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-09-13)
      In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic ...
    • The genetic architecture of human brainstem structures and their involvement in common brain disorders 

      Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik G.; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O’ Connell, Kevin S.; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar M.; Tsolaki, Magda; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Kaufmann, Tobias (Journal article, 2020)
      Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ...
    • Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes 

      Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders M; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-03-13)
      Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD ...
    • Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence 

      Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)
      Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ...
    • Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment 

      O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ...
    • Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder 

      O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)
      Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ...
    • Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment 

      Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-02)
      Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve ...