• Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis. Specific Immunity in Young Children 

      Jenum, Synne; Sivakumaran, Dhanasekaran; Ritz, Christian; Macaden, R; Doherty, TM; Grewal, Harleen; TB Trials Study, Group (Peer reviewed; Journal article, 2016)
      We have explored the added value of interferon-γ (IFNγ)– inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for ...
    • Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum 

      Jenum, Synne; Sivakumaran, Dhanasekaran; Lodha, Rakesh; Mukherjee, Aparna; Saini, Deepak Kumar; Singh, Sarman; Singh, Varinder; Medigeshi, Guruprasad; Haks, Marielle C.; Ottenhoff, Tom H.M.; Doherty, Timothy Mark; Kabra, Sushil K.; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-01-04)
      The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress “Towards Zero Deaths”. Whereas the sensitivity ...
    • BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome 

      Jenum, Synne; Bakken, Rasmus; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; Lodha, Rakesh; Singh, Sarman; Singh, Varinder; Haks, Marielle C.; Ottenhoff, Tom H.M.; Kabra, Sushil K.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-12-12)
      Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification ...
    • Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children 

      Gjøen, John Espen; Jenum, Synne; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; MacAden, Ragini; Kabra, Sushil K.; Lodha, Rakesh; Ottenhoff, Tom H.M.; Haks, Marielle C.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2017-07-19)
      Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ...