Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis. Specific Immunity in Young Children
Peer reviewed, Journal article
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Original versionJenum S, Sivakumaran D, Ritz C, Macaden R, Doherty T, Grewal H, TB Trials Study. Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis. Specific Immunity in Young Children. The Pediatric Infectious Disease Journal. 2016;35(12):1336-1338 https://doi.org/10.1097/inf.0000000000001328
We have explored the added value of interferon-γ (IFNγ)– inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.