Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis. Specific Immunity in Young Children

Jenum, Synne; Sivakumaran, Dhanasekaran; Ritz, Christian; Macaden, R; Doherty, TM; Grewal, Harleen; TB Trials Study, Group
Peer reviewed, Journal article
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URI
https://hdl.handle.net/1956/15959
Date
2016
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Original version
https://doi.org/10.1097/inf.0000000000001328
Abstract
We have explored the added value of interferon-γ (IFNγ)– inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.
Publisher
Wolters Kluwer
Journal
The Pediatric Infectious Disease Journal
Copyright
Copyright 2016 Wolters Kluwer Health, Inc
Attribution CC BY-NC-ND
Except where otherwise noted, this item's license is described as Attribution CC BY-NC-ND