Blar i Bergen Open Research Archive på forfatter "Skrede, Silje"
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Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat
Jassim, Goran; Skrede, Silje; Vázquez, María Jesús; Wergedahl, Hege; Vik-Mo, Audun O.; Lunder, Niclas; Diéguez, Carlos; Vidal-Puig, Antonio; Berge, Rolf Kristian; López, Miguel; Steen, Vidar Martin; Fernø, Johan (Peer reviewed; Journal article, 2011-07-12)This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of ... -
Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial
Henriksen, Tone Elise Gjøtterud; Skrede, Silje; Fasmer, Ole Bernt; Schøyen, Helle Kristine; Leskauskaite, Ieva; Bjørke-Bertheussen, Janette; Assmus, Jörg; Hamre, Børge; Grønli, Janne; Lund, Anders (Peer reviewed; Journal article, 2016-05)Objectives: The discovery of the blue lightsensitive retinal photoreceptor responsible for signaling daytime to the brain suggested that light to the circadian system could be inhibited by using blue-blocking orange tinted ... -
A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation
Kroken, Rune; Løberg, Else-Marie; Drønen, Tore; Grüner, Renate; Hugdahl, Kenneth; Kompus, Kristiina; Skrede, Silje; Johnsen, Erik (Peer reviewed; Journal article, 2014-02-04)Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic ... -
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells
Reikvam, Håkon; Brenner, Annette; Hagen, Karen Marie; Liseth, Knut; Skrede, Silje; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2015-11)Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. However, the molecular mechanisms involved in the cytokine-mediated crosstalk ... -
Developing a rodent model for antipsychotic-induced metabolic adverse effects
Skrede, Silje (Doctoral thesis, 2012-04-20)Antipsychotic agents represent efficient therapy for serious psychiatric disorders, particularly schizophrenia, but also bipolar disorder, and are used by millions of patients worldwide. Metabolic adverse effects of ... -
Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs
Fernø, Johan; Skrede, Silje; Vik-Mo, Audun O.; Håvik, Bjarte; Steen, Vidar Martin (Peer reviewed; Journal article, 2006-10-20)Background: The etiology of schizophrenia is unknown, but neurodevelopmental disturbances, myelin- and oligodendrocyte abnormalities and synaptic dysfunction have been suggested as pathophysiological factors in this severe ... -
Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study
Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan; Hughes, Timothy (Peer reviewed; Journal article, 2019)Lithium has been the first-line treatment for bipolar disorder (BD) for more than six decades. Although the molecular effects of lithium have been studied extensively and gene expression changes are generally believed to ... -
Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis
Skrede, Silje; Berg, Jon Andsnes; Fossan, Kjell Ove; Bartz-Johannessen, Christoffer; Løberg, Else-Marie; Kroken, Rune Andreas; Johnsen, Erik (Journal article, 2021)Background The prevalence of new psychoactive substances (NPS) in acute psychotic patients has not been investigated systematically. We applied a highly sensitive and specific mass spectrometry method for detection of NPS ... -
Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims
Steine, Iris Mulders; Zayats, Tetyana; Stansberg, Christine; Pallesen, Ståle; Mrdalj, Jelena; Håvik, Bjarte; Soule, Jonathan; Haavik, Jan; Milde, Anne Marita; Skrede, Silje; Murison, Robert; Krystal, John H; Grønli, Janne (Peer reviewed; Journal article, 2016-12-13)Sexual abuse contributes to the development of multiple forms of psychopathology, including anxiety and depression, but the extent to which genetics contributes to these disorders among sexual abuse victims remains unclear. ... -
Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis
Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid; Steen, Vidar Martin (Peer reviewed; Journal article, 2017-07)Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug ... -
Lipid-Lowering Effects of Tetradecylthioacetic Acid in Antipsychotic-Exposed, Female Rats: Challenges with Long-Term Treatment
Skrede, Silje; Fernø, Johan; Bjørndal, Bodil; Brede, Wenche Rødseth; Bohov, Pavol; Berge, Rolf Kristian; Steen, Vidar Martin (Peer reviewed; Journal article, 2012-11-30)Background: Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially ... -
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Journal article; Peer reviewed, 2021)Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ... -
No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex
Marti, Andrea Rørvik; Patil, Sudarshan; Mrdalj, Jelena; Meerlo, Peter; Skrede, Silje; Pallesen, Ståle; Pedersen, Torhild; Bramham, Clive R.; Grønli, Janne (Peer reviewed; Journal article, 2017-10-04)Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. ... -
Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation
Fernø, Johan; Varela, Luis; Skrede, Silje; Vázquez, María Jesús; Nogueiras, Rubén; Diéguez, Carlos; Vidal-Puig, Antonio; Steen, Vidar Martin; López, Miguel (Peer reviewed; Journal article, 2011-06-13)The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine ... -
One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects
Ersland, Kari Merete; Myrmel, Lene Secher; Fjære, Even; Berge, Rolf Kristian; Madsen, Lise; Steen, Vidar Martin; Skrede, Silje (Peer reviewed; Journal article, 2019-05)Background: Antipsychotic drugs can negatively affect the metabolic status of patients, with olanzapine as one of the most potent drugs. While patients are often medicated for long time periods, experiments in rats typically ... -
Shift in Food Intake and Changes in Metabolic Regulation and Gene Expression during Simulated Night-Shift Work: A Rat Model
Marti, Andrea Rørvik; Meerlo, Peter; Grønli, Janne; Hasselt, Sjoerd van; Mrdalj, Jelena; Pallesen, Ståle; Pedersen, Torhild; Henriksen, Tone Elise Gjøtterud; Skrede, Silje (Journal article; Peer reviewed, 2016)Night-shift work is linked to a shift in food intake toward the normal sleeping period, and to metabolic disturbance. We applied a rat model of night-shift work to assess the immediate effects of such a shift in food intake ... -
Short communication: Distribution of psychotropic drugs into lipoproteins
Serkland, Trond T.; Schjøtt, Jan; Berg, Jon Andsnes; Herfindal, Lars; Riedel, Bettina; Skrede, Silje (Peer reviewed; Journal article, 2019)Aim: The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) ... -
Understanding the Effects of Antipsychotics on Appetite Control
Mukherjee, Sayani; Skrede, Silje; Milbank, Edward; Andriantsitohaina, Ramaroson; López, Miguel; Fernø, Johan (Journal article; Peer reviewed, 2021)Antipsychotic drugs (APDs) represent a cornerstone in the treatment of schizophrenia and other psychoses. The effectiveness of the first generation (typical) APDs are hampered by so-called extrapyramidal side effects, and ...