dc.contributor.author | Mohamed, Hasaan Gassim | en_US |
dc.contributor.author | Idris, Shaza Bushra | en_US |
dc.contributor.author | Mustafa, Manal | en_US |
dc.contributor.author | Ahmed, Mutaz F. | en_US |
dc.contributor.author | Åstrøm, Anne Nordrehaug | en_US |
dc.contributor.author | Mustafa, Kamal Babikeir Eln | en_US |
dc.contributor.author | Ibrahim, Salah Osman | en_US |
dc.date.accessioned | 2016-01-05T09:38:09Z | |
dc.date.available | 2016-01-05T09:38:09Z | |
dc.date.issued | 2015-05-20 | |
dc.Published | PLoS ONE 2015, 10:e0127660(5) | eng |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/1956/10863 | |
dc.description.abstract | The relationship between diabetes and periodontal disease is bidirectional, but information about the effect of chronic periodontitis on the levels of the glucoregulatory biomarkers locally in gingival crevicular fluid (GCF) is limited. The aim of this study was to compare the levels of 10 glucoregulatory biomarkers in GCF, firstly in subjects with type 2 diabetes (T2DM) presenting with and without chronic periodontitis and secondly, in subjects without diabetes, with and without chronic periodontitis. The material comprised a total of 152 subjects, stratified as: 54 with T2DM and chronic periodontitis (G1), 24 with T2DM (G2), 30 with chronic periodontitis (G3) and 44 without T2DM or periodontitis (G4). The levels of the biomarkers were measured using multiplex biometric immunoassays. Periodontal pocket depths were recorded in mm. Subsets G1 and G2 and subsets G3 and G4 were compared independently. Among T2DM subjects, GIP, GLP-1 and glucagon were significantly up-regulated in G1 compared to G2. Moreover, there were no statistical differences between the two groups regarding C-peptide, insulin, ghrelin, leptin and PAI-1. Comparisons among individuals without T2DM revealed significantly lower amounts of C-peptide and ghrelin in G3 than in G4. The number of sites with pocket depth ≥ 4mm correlated negatively with C-peptide (Spearman's correlation co-efficient: -0.240, P < 0.01) and positively with GIP and visfatin (Spearman's correlation co-efficient: 0.255 and 0.241, respectively, P < 0.01). The results demonstrate that chronic periodontitis adversely influences the GCF levels of glucoregulatory biomarkers, as it is associated with disturbed levels of biomarkers related to the onset of T2DM and its medical complications. | en_US |
dc.language.iso | eng | eng |
dc.publisher | PLOS | eng |
dc.relation.ispartof | <a href="http://hdl.handle.net/1956/11004" target="blank">Impact of type 2 diabetes and periodontal disease on oral status of Sudanese adults. Clinical, microbial and immune-inflammatory aspects</a> | |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | Chronic periodontitis | eng |
dc.subject | Glucoregulatory Biomarkers | eng |
dc.subject | Gingival Crevicular Fluid | eng |
dc.subject | Type 2 diabetes | eng |
dc.title | Impact of chronic periodontitis on levels of glucoregulatory biomarkers in gingival crevicular fluid of adults with and without type 2 diabetes | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-22T10:31:02Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 Mohamed et al. | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0127660 | |
dc.identifier.cristin | 1245259 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk odontologiske fag: 830::Periodonti: 837 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical dentistry sciences: 830::Periodontics: 837 | |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |