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dc.contributor.authorBrandt, Christine Lycke
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorTønnesen, Siren
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorHugdahl, Kenneth
dc.contributor.authorMelle, Ingrid
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorWestlye, Lars Tjelta
dc.PublishedNeuroImage: Clinical 2015, 9:253-263eng
dc.description.abstractSchizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural cortical and subcortical brain abnormalities have been documented, but little is known about how task-related brain activation is associated with brain anatomy in SZ compared to healthy controls (HC). Utilizing linked independent component analysis (LICA), a data-driven multimodal analysis approach, we investigated structure–function associations in a large sample of SZ (n = 96) and HC (n = 142). We tested for associations between task-positive (fronto-parietal) and task-negative (default-mode) brain networks derived from fMRI activation during an n-back working memory task, and brain structural measures of surface area, cortical thickness, and gray matter volume, and to what extent these associations differed in SZ compared to HC. A significant association (p < .05, corrected for multiple comparisons) was found between a component reflecting the task-positive fronto-parietal network and another component reflecting cortical thickness in fronto-temporal brain regions in SZ, indicating increased activation with increased thickness. Other structure–function associations across, between and within groups were generally moderate and significant at a nominal p-level only, with more numerous and stronger associations in SZ compared to HC. These results indicate a complex pattern of moderate associations between brain activation during cognitive processing and brain morphometry, and extend previous findings of fronto-temporal brain abnormalities in SZ by suggesting a coupling between cortical thickness of these brain regions and working memory-related brain activation.en_US
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectFunctional magnetic resonance imagingeng
dc.subjectLinked independent component analysiseng
dc.titleAssessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysiseng
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authorseng
dc.relation.projectNorges forskningsråd: 204966

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