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Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
(Journal article; Peer reviewed, 2023)Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ... -
Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers
(Journal article; Peer reviewed, 2023)Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with ... -
Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day
(Journal article; Peer reviewed, 2023)Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications ... -
Challenges, limitations, and measurement strategies to ensure data quality in deep-sea sensors
(Journal article; Peer reviewed, 2023-04-06)In this paper we give an overview of factors and limitations impairing deep-sea sensor data, and we show how automatic tests can give sensors self-validation and self-diagnostic capabilities. This work is intended to lay ... -
Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean
(Journal article; Peer reviewed, 2023)Bioaccumulation of persistent organic pollutants (POPs) in marine fish may pose a health risk to human consumers. Using data from ∼8400 individuals of 15 fish species collected in the North-East Atlantic Ocean (NEAO), we ... -
It’s About Time! Temporal Dynamics and Longitudinal Research Designs in Public Administration
(Journal article; Peer reviewed, 2023)Many of the fundamental research questions in public administration relate to individual- or organization-level temporal dynamics, including the impact of public sector reforms, (in)stability of public policies and ... -
Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both
(Journal article; Peer reviewed, 2023)Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients ... -
CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation
(Journal article; Peer reviewed, 2023)Prostate cancer is often treated by perturbing androgen receptor signalling. CACNA1D, encoding CaV1.3 ion channels is upregulated in prostate cancer. Here we show how hormone therapy affects CACNA1D expression and CaV1.3 ... -
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
(Journal article; Peer reviewed, 2023)Purpose: Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have inflammatory complications ... -
Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample
(Journal article; Peer reviewed, 2023)Background/Objectives: Food hypersensitivity (FHS) is common, but little is known about the factors associated with severe reactions, age of onset and whether sensitization persists. This study examines the factors associated ... -
Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers
(Journal article; Peer reviewed, 2023)The International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB) provides educational documents to facilitate the interpretation and use of cardiac biomarkers in ... -
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
(Journal article; Peer reviewed, 2023-08-01)Background: Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of ... -
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma
(Journal article; Peer reviewed, 2023)This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and ... -
The Genre of the Royal Crisis Address: Six European Monarchs’ Rhetorical Responses to the Covid-19 Pandemic
(Journal article; Peer reviewed, 2023)This article offers a rhetorical analysis of the addresses delivered by six Northern European monarchs in response to the Covid-19 pandemic in early 2020. The analysis establishes a new genre with distinctive traits and ... -
Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?
(Journal article; Peer reviewed, 2023-03-17)Background: Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists ... -
Training of medical students in the use of emergency whole blood collection and transfusion in the framework of a civilian walking blood
(Journal article; Peer reviewed, 2023)Introduction: In this report, we describe a training program in emergency whole blood collection and transfusion for medical students at the University of Bergen. The overall aim of the program is to improve the availability ... -
Glacier thinning, recession and advance, and the associated evolution of a glacial lake between 1966 and 2021 at Austerdalsbreen, western Norway
(Journal article; Peer reviewed, 2023)The Jostedalsbreen is the largest ice cap in Norway and mainland Europe. Rapid retreat of many of its outlet glaciers since the 2000s has led to the formation of several glacial lakes. Processes causing the formation and ... -
DarSIA: An Open-Source Python Toolbox for Two-Scale Image Processing of Dynamics in Porous Media
(Journal article; Peer reviewed, 2023)Understanding porous media flow is inherently a multi-scale challenge, where at the core lies the aggregation of pore-level processes to a continuum, or Darcy-scale, description. This challenge is directly mirrored in image ... -
Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
(Journal article; Peer reviewed, 2023)Background: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ... -
The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression
(Journal article; Peer reviewed, 2023)Background Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while ...
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