• An environmentally benign and high-rate Appel type reaction 

  Fuenzalida, Nicolas Mattias del Rio; Alme, Eirin; Lundevall, Frida Johanne; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2022)

  A high rate, selective, and productive Appel type reaction was developed. The method allows for ipso-substitution of the alcoholic hydroxy group with halogens ∈ [Cl, Br, I]. The method demands mild reaction conditions that ...

• Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts 

  Pezoulas, Vasileios C.; Goules, Andreas; Kalatzis, Fanis; Chatzis, Luke; Kourou, Konstantina D.; Venetsanopoulou, Aliki; Exarchos, Themis P.; Gandolfo, Saviana; Votis, Konstantinos; Zampeli, Evi; Burmeister, Jan; May, Thorsten; Marcelino Pérez, Manuel; Lishchuk, Iryna; Chondrogiannis, Thymios; Andronikou, Vassiliki; Varvarigou, Theodora; Filipovic, Nenad; Tsiknakis, Manolis; Baldini, Chiara; Bombardieri, Michele; Bootsma, Hendrika; Bowman, Simon J.; Shahnawaz Soyfoo, Muhammad; Parisis, Dorian; Delporte, Christine; Devauchelle-Pensec, Valérie; Pers, Jacques-Olivier; Dörner, Thomas; Bartoloni, Elena; Gerli, Roberto; Giacomelli, Roberto; Jonsson, Roland; Ng, Wan-Fai; Priori, Roberta; Ramos-Casals, Manuel; Sivils, Kathy; Skopouli, Fotini; Torsten, Witte; A. G. van Roon, Joel; Xavier, Mariette; De Vita, Salvatore; Tzioufas, Athanasios G.; Fotiadis, Dimitrios I. (Journal article; Peer reviewed, 2022)

  For many decades, the clinical unmet needs of primary Sjögren’s Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the ...

• Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study 

  Linde, Lorentz Erland; Ebbing, Cathrine; Moster, Dag; Kessler, Jørg; Baghestan, Elham; Gissler, Mika; Rasmussen, Svein (Journal article; Peer reviewed, 2022)

  Purpose: This study examines individual aggregation of postpartum hemorrhage (PPH), paternal contribution and how offspring birthweight and sex influence recurrence of PPH. Further, we wanted to estimate the proportion of ...

• MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells 

  Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2022-03-17)

  Background: Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its ...

• LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions 

  Lybæk, Helle; Robson, Michael; de Leeuw, Nicole; Hehir-Kwa, Jayne Y.; Jeffries, Aaron; Haukanes, Bjørn Ivar; Berland, Siren; de Bruijn, Diederik; Mundlos, Stefan; Spielmann, Malte; Houge, Gunnar Douzgos (Journal article; Peer reviewed, 2022)

  LRFN5 is a regulator of synaptic development and the only gene in a 5.4 Mb mammalian-specific conserved topologically associating domain (TAD); the LRFN5 locus. An association between locus structural changes and developmental ...

• Kaplan-Meier and Cox Regression Are Preferable for the Analysis of Time to Revision of Joint Arthroplasty: Thirty-One Years of Follow-up for Cemented and Uncemented THAs Inserted from 1987 to 2000 in the Norwegian Arthroplasty Register 

  Lie, Stein Atle; Fenstad, Anne Marie; Lygre, Stein Håkon Låstad; Kroken, Gard; Dybvik, Eva Hansen; Gjertsen, Jan-Erik; Hallan, Geir; Dale, Håvard; Furnes, Ove Nord (Journal article; Peer reviewed, 2022)

  Background: Previous studies have suggested that the probability function of 1 minus the Kaplan-Meier survivorship overestimates revision rates of implants and that patient death should be included in estimates as a competing ...

• Buegangsdehiscens 

  Goplen, Frederik Kragerud; Hess-Erga, Jeanette; Opheim, Leif Runar; Silvola, Juha Tapio; Stene, Brit Kari; Törpel, Jörg; Uppheim, Alexander; Bunne, Bodil Iris Marie (Journal article; Peer reviewed, 2022)

  Buegangsdehiscens er en tilstand med plagsomme øresymptomer og svimmelhet forårsaket av en defekt i benet mellom det indre øret og midtre skallegrop. Sykdommen er ufarlig, og for mange pasienter er det tilstrekkelig med ...

• The nonlinearities in the galvanostatic charging curves of supercapacitors provide insights into charging mechanisms 

  Helseth, Lars Egil (Journal article; Peer reviewed, 2022)

  Supercapacitors are often charged using constant currents. The capacitance can be determined from the slope of the voltage-time curve if the measured voltage over the supercapacitor increases linearly with time. However, ...

• Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

  Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Peer reviewed, 2022)

  Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ...

• Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement 

  Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Kristoffersen, Per Martin; Vetti, Nils; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Schistad, Ellina Iordanova; Haugen, Anne Julsrud; Johanessen, Anne Froholdt; Skouen, Jan Sture; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Lie, Benedicte Alexandra (Journal article; Peer reviewed, 2022-01-07)

  Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI ...

• Systematic reporting of medical kidney biopsies 

  Leh, Sabine; Dendooven, Amélie (Journal article; Peer reviewed, 2022)

  The medical kidney biopsy has an important added value in patient care in nephrology. In order to facilitate communication between the pathologist and the nephrologist and optimize patient care, both the content and form ...

• Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis 

  Lindland, Elisabeth Margrete Stokke; Solheim, Anne Marit; Dareez, Muhammad Nazeer; Eikeland, Randi; Ljøstad, Unn; Mygland, Åse Daasvand; Reiso, Harald; Lorentzen, Åslaug Rudjord; Harbo, Hanne; Beyer, Mona Kristiansen (Journal article; Peer reviewed, 2022)

  Purpose Symptoms of cranial neuritis are a common presentation of Lyme neuroborreliosis (LNB). Imaging studies are scarce and report contradictory low prevalence of enhancement compared to clinical studies of cranial ...

• Association of adverse childhood experiences with the development of multiple sclerosis 

  Eid, Karine; Torkildsen, Øivind; Aarseth, Jan Harald; Aalstad, Mari; Bhan, Alok; Celius, Elisabeth Gulowsen; Cortese, Marianna; Daltveit, Anne Kjersti Nesje; Holmøy, Trygve; Myhr, Kjell-Morten; Riise, Trond; Schuler, Stephan; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)

  Objective To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development. Methods A nationwide, prospective cohort study based on participants ...

• Changes in colonic enteroendocrine cells of patients with irritable bowel syndrome following fecal microbiota transplantation 

  Mazzawi, Tarek; Hausken, Trygve; El-Salhy, Magdy (Journal article; Peer reviewed, 2022)

  Objectives The aim was to investigate the effect of fecal microbiota transplantation (FMT) on colonic enteroendocrine cells densities in patients with irritable bowel syndrome (IBS). Materials and methods This study ...

• Lack of population genetic structure of lumpfish along the Norwegian coast: A reappraisal based on EST-STRs analyses 

  Jónsdóttir, Ólöf Dóra Bartels; Gíslason, Davíð; Ólafsdóttir, Guðbjörg; Maduna, Simo; Hagen, Snorre; Reynolds, Patrick; Sveinsson, Sæmundur; Imsland, Albert (Journal article; Peer reviewed, 2022)

  Lumpfish is now the single most important cleaner fish species to date and there is an extensive lumpfish translocation along the Norwegian coast. A reliable baseline information about the population genetic structure of ...

• Trends in Mortality Due to Myocardial Infarction, Stroke, and Pulmonary Embolism in Patients Receiving Dialysis 

  Ocak, Gurbey; Boenink, Rianne; Noordzij, Marlies; Bos, Willem Jan W.; Vikse, Bjørn Egil; Cases, Aleix; Kerschbaum, Julia; Helve, Jaakko; Nordio, Maurizio; Arici, Mustafa; Mercadal, Lucile; Wanner, Christoph; Palsson, Runolfur; Hommel, Kristine; De Meester, Johan; Kostopoulou, Myrto; Santamaria, Rafael; Rodrigo, Emilio; Rydell, Helena; Bell, Samira; Massy, Ziad A.; Jager, Kitty J.; Kramer, Anneke (Journal article; Peer reviewed, 2022)

  Importance: During the past decades, improvements in the prevention and management of myocardial infarction, stroke, and pulmonary embolism have led to a decline in cardiovascular mortality in the general population. ...

• Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study 

  Olsen, Cathrine Goberg; Busk, Øyvind Løvold; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjørnå, Ingrid Kristine; Braathen, Geir Julius; Breivik, Kristin Lif; Demic, Natasha; Flemmen, Heidi Øyen; Hallerstig, Erika; HogenEsch, Ineke; Holla, Øystein Lunde; Jøntvedt, Anne Berit; Kampman, Margitta T.; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Åse Hagen; Nakken, Ola; Novy, Camilla; Rekand, Tiina; Schlüter, Katrin Ruth; Schuler, Stephan; Tveten, Kristian; Tysnes, Ole-Bjørn; Holmøy, Trygve; Høyer, Helle (Journal article; Peer reviewed, 2022)

  Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ...

• Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas 

  Schem, Baard-Christian; Pfeffer, Frank; Ott, Martin Anton; Wiig, Johan N.; Sletteskog, Nils; Frøystein, Torbjørn; Myklebust, Mette Pernille; Leh, Sabine; Dahl, Olav; Mella, Olav (Journal article; Peer reviewed, 2022-01-29)

  Hyperthermia was added to standard preoperative chemoradiation for rectal adenocarcinomas in a phase II study. Patients with T3-4 N0-2 M0 rectal cancer or local recurrences were included. Radiation dose was 54 Gy combined ...

• Vurderingsstrategi og retningslinjer for vurdering - Rapport fra arbeidsgruppen 

  Nerheim, Magnus Svendsen; Balevik, Stine Beate; Boge, Cecilie; Raaheim, Arild; Voster, Ingunn (Research report, 2019)

• Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease? 

  Flønes, Irene Hana; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)

  Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ...

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