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Earlier sea-ice melt extends the oligotrophic summer period in the Barents Sea with low algal biomass and associated low vertical flux
(Journal article; Peer reviewed, 2023)The decrease in Arctic sea-ice extent and thickness as a result of global warming will impact the timing, duration, magnitude and composition of phytoplankton production with cascading effects on Arctic marine food-webs ... -
Earliest human burial in Africa
(Journal article; Peer reviewed, 2021)The origin and evolution of hominin mortuary practices are topics of intense interest and debate1,2,3. Human burials dated to the Middle Stone Age (MSA) are exceedingly rare in Africa and unknown in East Africa1,2,3,4,5,6. ... -
Early anthropogenic use of hematite on Aurignacian ivory personal ornaments from Hohle Fels and Vogelherd caves, Germany
(Journal article; Peer reviewed, 2021)The Aurignacian (ca. 43–35 ka) of southwestern Germany is well known for yielding some of the oldest artifacts related to symbolic behaviors, including examples of figurative art, musical instruments, and personal ornaments. ... -
Early Behavioral Interventions for Children and Adolescents With Autism Spectrum Disorder in Routine Clinical Care: A Systematic Review and Meta-Analysis
(Journal article; Peer reviewed, 2022)The current paper systematically reviews and meta-analyses the effectiveness of early behavioral interventions (BI) for children with autism spectrum disorder (ASD) in routine clinical care. The effectiveness of BI, ... -
The Early Branching Group of Orbiniida Sensu Struck et al., 2015: Parergodrilidae and Orbiniidae
(Journal article; Peer reviewed, 2021)This review addresses the state of the art of the systematics and the improvements in the biology, ecology and species diversity of the two annelid taxa Parergodrilidae and Orbiniidae, the early branching group of Orbiniida ... -
Early child stimulation, linear growth and neurodevelopment in low birth weight infants
(Journal article; Peer reviewed, 2022)Background Children with low birth weight (LBW) are at risk of linear growth faltering and developmental deficits. Evidence suggests that early child stimulation and care reflected as responsive caregiving and opportunities ... -
Early constipation predicts faster dementia onset in Parkinson's disease
(Journal article; Peer reviewed, 2021)Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s ... -
Early detection of anthropogenic climate change signals in the ocean interior
(Journal article; Peer reviewed, 2023)Robust detection of anthropogenic climate change is crucial to: (i) improve our understanding of Earth system responses to external forcing, (ii) reduce uncertainty in future climate projections, and (iii) develop efficient ... -
Early diagnosis is associated with improved clinical outcomes in benign esophageal perforation: an individual patient data meta‑analysis
(Journal article; Peer reviewed, 2020)Background Time of diagnosis (TOD) of benign esophageal perforation is regarded as an important risk factor for clinical outcome, although convincing evidence is lacking. The aim of this study is to assess whether time ... -
Early Diagnosis of Pancreatic Cancer: Clinical Premonitions, Timely Precursor Detection and Increased Curative-Intent Surgery
(Journal article; Peer reviewed, 2023)Background: The overall poor prognosis in pancreatic cancer is related to late clinical detection. Early diagnosis remains a considerable challenge in pancreatic cancer. Unfortunately, the onset of clinical symptoms in ... -
Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: A population-based cohort
(Journal article; Peer reviewed, 2022)Objective: The objective of this study was to evaluate the association between empirical antibiotic therapy in the first postnatal week in uninfected infants born very preterm and the risk of adverse outcomes until ... -
Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria
(Journal article; Peer reviewed, 2022)Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ... -
Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
(Journal article; Peer reviewed, 2022)Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) ... -
Early Gut Fungal and Bacterial Microbiota and Childhood Growth
(Journal article; Peer reviewed, 2020)Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ... -
Early Holocene Temperature Oscillations Exceed Amplitude of Observed and Projected Warming in Svalbard Lakes
(Journal article; Peer reviewed, 2019)Arctic climate is uniquely sensitive to ongoing warming. The feedbacks that drive this amplified response remain insufficiently quantified and misrepresented in model scenarios of future warming. Comparison with paleotemperature ... -
Early human impacts and ecosystem reorganization in southern-central Africa
(Journal article; Peer reviewed, 2021-05-05)Modern Homo sapiens engage in substantial ecosystem modification, but it is difficult to detect the origins or early consequences of these behaviors. Archaeological, geochronological, geomorphological, and paleoenvironmental ... -
Early identification of treatment non-response in first-episode psychosis
(Journal article; Peer reviewed, 2023)Background Approximately one-third of patients with psychotic disorders does not respond to standard antipsychotic treatments. Consensus criteria for treatment resistance (TR) may aid the identification of non-response ... -
Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation: Findings from the opinion-based PREDICT-FD modified Delphi consensus initiative
(Journal article; Peer reviewed, 2020)Objectives The PRoposing Early Disease Indicators for Clinical Tracking in Fabry Disease (PREDICT-FD) initiative aimed to reach consensus among a panel of global experts on early indicators of disease progression that may ... -
Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children
(Journal article; Peer reviewed, 2020)Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ... -
Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population
(Journal article; Peer reviewed, 2023)Background We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults ...