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    • Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies 

      Leclair, Valérie; Galindo-Feria, Angeles S.; Rothwell, Simon; Kryštůfková, Olga; Zargar, Sepehr Sarrafzadeh; Mann, Herman; Diederichsen, Louise Pyndt; Andersson, Anna Helena; Klein, Martin; Tansley, Sarah; Rönnblom, Lars; Lindblad-Toh, Kerstin; Syvänen, Ann-Christine; Wahren Herlenius, Marie Elisabeth; Sandling, Johanna K.; Bianchi, Matteo; Lundberg, Ingrid E.; Padyukov, Leonid; Molberg, Øyvind; Lamb, Janine A.; Chinoy, Hector; Holmqvist, Marie; Diaz-Gallo, Lina-Marcela (Journal article; Peer reviewed, 2023)
      Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles ...

    • Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model 

      Mostafavi, Sepideh; Balafkan, Novin; Pettersen, Ina Katrine Nitschke; Nido, Gonzalo Sanchez; Siller, Richard; Tzoulis, Charalampos; Sullivan, Gareth John; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2021-10-14)
      Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time 

      Kenny, Grace; O’Reilly, Sophie; Wrigley Kelly, Neil; Negi, Riya; Gaillard, Colette; Alalwan, Dana; Saini, Gurvin; Alrawahneh, Tamara; Francois, Nathan; Angeliadis, Matthew; Garcia Leon, Alejandro Abner; Tinago, Willard; Feeney, Eoin R.; Cotter, Aoife G.; de Barra, Eoghan; Yousif, Obada; Horgan, Mary; Doran, Peter; Stemler, Jannik; Koehler, Philipp; Cox, Rebecca Jane; O’Shea, Donal; Olesen, Ole F.; Landay, Alan; Hogan, Andrew E.; Lelievre, Jean-Daniel; Gautier, Virginie; Cornely, Oliver A.; Mallon, Patrick W. G.; Leon, Alejandro Garcia; Feeney, Eoin; Mallon, Patrick (Journal article; Peer reviewed, 2023)
      SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as surrogate markers of neutralising capacity, but whether these ...

    • Distinct T cell subsets in adipose tissue are associated with obesity 

      Haugstøyl, Martha Eimstad; Cornillet, Martin; Strand, Kristina; Stiglund, Natalie; Sun, Dan; Lawrence-Archer, Laurence; Hjellestad, Iren Drange; Sparrelid, Ernesto; Busch, Christian; Hjelmesæth, Jøran Sture; Hertel, Jens Kristoffer; Ponzetta, Andrea; Mellgren, Gunnar; Fernø, Johan; Björkström, Niklas K. (Journal article; Peer reviewed, 2022)
      Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data ...

    • Distinctions Between Self-Report and Performance-Based Measures of Physical Function in Older Patients Prior to Chemotherapy 

      Torstveit, Ann Helen; Løyland, Borghild; Grov, Ellen Karine; Guren, Marianne; Paul, Steven M.; Ritchie, Christine; Vistad, Ingvild; Miaskowski, Christine; Utne, Inger (Journal article; Peer reviewed, 2021)
      Background: The maintenance of physical function (PF) is an extremely important outcome for older adults. Objective: The aims of this study were to, identify differences in subjective and objective measures of PF between ...

    • Distinguishing Septal Heart Defects from the Valvular Regurgitation Using Intelligent Phonocardiography 

      Gharehbaghi, Arash; Sepehri, Amir A; Babic, Ankica (Journal article; Peer reviewed, 2020)
      This paper presents an original machine learning method for extracting diagnostic medical information from heart sound recordings. The method is proposed to be integrated with an intelligent phonocardiography in order to ...

    • Distributed team processes in healthcare services: a scoping review 

      Eid, Jarle; Brattebø, Guttorm; Espevik, Roar; Johan K, Jacobsen; Bjørn Helge, Johnsen (Journal article; Peer reviewed, 2023)
      Objective: High-quality healthcare services is delivered by teams rather than individuals and depends heavily on multidisciplinary cooperation between dispersed healthcare professionals. The aim of this scoping review is ...

    • Distribution and Determinants of Serum Zinc, Copper, and Selenium Levels among Children under Five Years from Popokabaka, Democratic Republic of Congo: A Cross-Sectional Study 

      Mbunga, Branly Kilola; Engebretsen, Ingunn Marie Stadskleiv; Strand, Tor Arne; Gjengedal, Elin Lovise Folven; Akilimali, Pierre Z.; Langfjord, Mina Marthinsen; Tugirimana, Pierrot L.; Mapatano, Mala Ali (Journal article; Peer reviewed, 2022)
      Information about essential trace elements among children in many African countries, including the Democratic Republic of Congo (DRC), is limited. We aimed to measure the distribution and determinants of serum zinc (Zn), ...

    • Distribution and Occurrence Frequency of dB/dt Spikes During Magnetic Storms 1980–2020 

      Schillings, A.; Palin, L.; Opgenoorth, H.J.; Hamrin, M.; Rosenqvist, L.; Gjerløv, Jesper; Juusola, Liisa; Barnes, R. (Journal article; Peer reviewed, 2022)
      The physical magnetospheric cause for geomagnetically induced currents (GICs) are rapid time-varying magnetic fields (dB/dt), which occur mainly during magnetic substorms and storms. When, where and why exactly such rapid ...

    • Distribution and suitable habitat of the cold-water corals Lophelia pertusa, Paragorgia arborea, and Primnoa resedaeformis on the Norwegian continental shelf 

      Sundahl, Hanna; Buhl-Mortensen, Pål; Buhl-Mortensen, Lene (Journal article; Peer reviewed, 2020)
      Cold-water corals are habitat-forming species that are also classified as indicators of vulnerable marine ecosystems (VMEs) due to the threat of various anthropogenic impacts, e.g., fisheries and oil/mineral exploration. ...

    • Distribution of discontinuous Mudstone beds within wavedominated shallow-marine deposits: Star point sandstone and blackhawk formation, Eastern Utah 

      Eide, Christian Haug; Howell, John Anthony; Buckley, Simon John (Journal article; Peer reviewed, 2014)
      Deposits of wave-dominated shorelines are typically considered to act as relatively simple hydrocarbon reservoirs and are commonly modeled as “tanks of sand.” However, important heterogeneities that can act as barriers to ...

    • The Distribution of IgT mRNA+ Cells in the Gut of the Atlantic Salmon (Salmo salar L.) 

      Castro, Pedro Luis; Barac, Fran; Hansen, Tom Johnny; Fjelldal, Per Gunnar; Hordvik, Ivar; Bjørgen, Håvard; Koppang, Erling Olaf (Journal article; Peer reviewed, 2023)
      The newly discovered IgT+ B cell is thought to play a dominant role in mucosal immunity, but limited studies have examined its distribution in fish species, hindering our understanding of its function. This study investigated ...

    • Distribution of Kudoa thyrsites (Cnidaria, Myxozoa) myoliquefactive stages in Northeast Atlantic mackerel (Scomber scombrus) inferred from qPCR and histology 

      Giulietti, Lucilla; Johansen Nedberg, Heidi; Karlsbakk, Egil Erlingsson; Marathe, Nachiket Prakash; Storesund, Julia Endresen; Mæhle, Stig; Fiksdal, Ingrid Uglenes; Ghebretnsae, Dawit Berhe; Levsen, Arne (Journal article; Peer reviewed, 2022)
      Kudoa thyrsites is a myxosporean parasite (Cnidaria, Myxozoa) that infects the skeletal and cardiac muscle of Northeast Atlantic (NEA) mackerel (Scomber scombrus). Heavy infections are associated with post-mortem myoliquefaction ...

    • The distribution of lichens and mosses at Edward VII Peninsula, Marie Byrd Land, Antarctica 

      Ochyra, Ryszard; Øvstedal, Dag Olav; Broady, Paul A. (Journal article; Peer reviewed, 2022)
      This is the first detailed study of the distribution of mosses and lichens at Alexandra Mountains and Rockefeller Mountains, Edward VII Peninsula, Antarctica. A total of 418 samples was collected on 21 nunataks in the ...

    • Distributional impact of infectious disease interventions in the Ethiopian Essential Health Service Package: a modelling study 

      Assebe, Lelisa Fekadu; Norheim, Ole Frithjof (Journal article; Peer reviewed, 2023)
      Objectives Reducing inequalities in health and financial risk are key goals on the path toward universal health coverage, particularly in low-income and middle-income countries. The design of the health benefit package ...

    • Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Skarpengland, Tonje; Berge, Rolf Kristian; Fevang, Børre; Halvorsen, Bente; Aukrust, Pål (Journal article; Peer reviewed, 2023)
      The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity ...

    • Disulfiram, a ferroptosis inducer, triggers lysosomal membrane permeabilization by up-regulating ROS in glioblastoma 

      Qiu, Chen; Zhang, Xin; Huang, Bin; Wang, Shuai; Zhou, Wenjing; Li, Chao; Li, Xingang; Wang, Jian; Yang, Ning (Journal article; Peer reviewed, 2020)
      Introduction: Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and ...

    • Diurnal gait fluctuations in single- and dual- task conditions 

      Bessot, Nicolas; Polyte, Raphaël; Quesney, Marius; Bulla, Jan; Gauthier, Antoine (Journal article; Peer reviewed, 2020)
      Gait is one of the most basic movements, and walking activity accomplished in dual task conditions realistically represents daily life mobility. Much is known about diurnal variations of gait components such as muscle ...

    • Diurnal temperature range as a key predictor of plants’ elevation ranges globally 

      Gallou, Arnaud; Jump, Alistair S.; Lynn, Joshua; Field, Richard; Irl, Severin D. H.; Steinbauer, Manuel; Beierkuhnlein, Carl; Chen, Jan-Chang; Chou, Chang-Hung; Hemp, Andreas; Kidane, Yohannes; König, Christian; Kreft, Holger; Naqinezhad, Alireza; Nowak, Arkadiusz; Nuppenau, Jan-Niklas; Trigas, Panayiotis; Price, Jonathan P.; Roland, Carl A.; Schweiger, Andreas H.; Weigelt, Patrick; Flantua, Suzette; Grytnes, John Arvid (Journal article; Peer reviewed, 2023)
      A prominent hypothesis in ecology is that larger species ranges are found in more variable climates because species develop broader environmental tolerances, predicting a positive range size-temperature variability ...