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    • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

      Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Peer reviewed, 2023)
      Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...

    • Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 

      Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article; Peer reviewed, 2020)
      Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ...

    • Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation 

      Berge-Seidl, Sebastian; Nielsen, Nis Valentin; Alfonso, Armando A Rodriguez; Etscheid, Michael; Kandanur, Sai Priya Sarma; Haug, Bengt Erik; Stensland, Maria; Thiede, Bernd; Karacan, M; Preising, N; Wiese, S; Standker, L; Declerck, Paul J.; Løset, Geir Åge; Kanse, Sandip (Journal article; Peer reviewed, 2022)
      Factor VII Activating protease (FSAP) has a protective effect in diverse disease conditions as inferred from studies in FSAP–/– mice and humans deficient in FSAP activity due to single-nucleotide polymorphism. The zymogen ...

    • Identification of biomarkers for glycaemic deterioration in type 2 diabetes 

      Slieker, Roderick C.; Donnelly, Louise A.; Akalestou, Elina; Lopez-Noriega, Livia; Melhem, Rana; Güneş, Ayşim; Abou Azar, Frederic; Efanov, Alexander; Georgiadou, Eleni; Muniangi-Muhitu, Hermine; Sheikh, Mahsa; Giordano, Giuseppe N.; Åkerlund, Mikael; Ahlqvist, Emma; Ali, Ashfaq; Banasik, Karina; Brunak, Søren; Barovic, Marko; Bouland, Gerard A.; Burdet, Frédéric; Canouil, Mickaël; Dragan, Iulian; Elders, Petra J. M.; Fernandez, Celine; Festa, Andreas; Fitipaldi, Hugo; Froguel, Phillippe; Gudmundsdottir, Valborg; Gudnason, Vilmundur; Gerl, Mathias J.; van der Heijden, Amber A.; Jennings, Lori L.; Hansen, Michael K.; Kim, Min; Leclerc, Isabelle; Klose, Christian; Kuznetsov, Dmitry; Mansour Aly, Dina; Mehl, Florence; Marek, Diana; Melander, Olle; Niknejad, Anne; Ottosson, Filip; Pavo, Imre; Duffin, Kevin; Syed, Samreen K.; Shaw, Janice L.; Cabrera, Over; Pullen, Timothy J.; Simons, Kai; Solimena, Michele; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido Quigley, Cristina; Groop, Leif; Thorens, Bernard; Franks, Paul W.; Lim, Gareth E.; Estall, Jennifer; Ibberson, Mark; Beulens, Joline W. J.; ’t Hart, Leen M; Pearson, Ewan R.; Rutter, Guy A. (Journal article; Peer reviewed, 2023)
      We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ...

    • Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis 

      Kong, Yang; Xue, Zhiwei; Wang, Haiying; Cui, Guangqiang; Chen, Anjing; Liu, Jie; Wang, Jian; Li, Xingang; Huang, Bin (Journal article; Peer reviewed, 2022)
      Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer. However, in ...

    • Identification of critical enzymes in the salmon louse chitin synthesis pathway as revealed by RNA interference-mediated abrogation of infectivity 

      Braden, Laura; Michaud, Dylan; Igboeli, Okechukwu O.; Dondrup, Michael; Hamre, Lars Are; Dalvin, Sussie; Purcell, Sara; Kongshaug, Heidi; Eichner, Christiane; Nilsen, Frank; Fast, Mark D. (Journal article; Peer reviewed, 2020)
      Treatment of infestation by the ectoparasite Lepeophtheirus salmonis relies on a small number of chemotherapeutant treatments that currently meet with limited success. Drugs targeting chitin synthesis have been largely ...

    • Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism 

      Reyes-Calderón, Almendra; Gutiérrez-García, Claudia; Urióstegui-Pena, Andrea G.; Srivastava, Aashish; Aguilar-Marcelino, Liliana; Iqbal, Hafiz M. N.; Ahmed, Shiek S. S. J.; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2023-04-25)
      The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ...

    • Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach 

      Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2023)
      Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ...

    • Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis 

      Khalid, Shizza; Ambreen, Atiqa; Khaliq, Aasia; Ullah, Hafeez; Mustafa, Manal; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)
      There is a lack of objective tools for monitoring treatment response in extrapulmonary tuberculosis (EPTB). This study aimed to explore the utility of inflammatory biomarkers from the dry blood spots (DBS) as a tool for ...

    • Identification of housekeeping genes of Candidatus Branchiomonas cysticola associated with epitheliocystis in Atlantic salmon (Salmo salar L.) 

      Mjølnerød, Even Bysveen; Srivastava, Aashish; Moore, Lindsey; Plarre, Heidrun; Nylund, Are (Journal article; Peer reviewed, 2022)
      Candidatus Branchiomonas cysticola is an intracellular, gram-negative Betaproteobacteria causing epitheliocystis in Atlantic Salmon (Salmo salar L.). The bacterium has not been genetically characterized at the intraspecific ...

    • Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis 

      Kong, Yang; Feng, Zichao; Zhang, Yulin; Liu, Xiaofei; Ma, Yuan; Zhao, Zhimin; Huang, Bin; Chen, An-Jing; Zhang, Di; Thorsen, Frits; Wang, Jian; Yang, Ning; Li, Xingang (Journal article; Peer reviewed, 2020)
      Background: The tumor microenvironment (TME) of human glioblastoma (GBM) exhibits considerable immune cell infiltration, and such cell types have been shown to be widely involved in the development of GBM. Here, weighted ...

    • Identification of in vivo induced antigens of the malacosporean parasite Tetracapsuloides bryosalmonae (Cnidaria) using in vivo induced antigen technology 

      Kumar, Gokhlesh; Sudhagar, Arun; Shivam, Saloni; Nilsen, Frank; Bartholomew, Jerri L.; El-Matbouli, Mansour (Journal article; Peer reviewed, 2022)
      Tetracapsuloides bryosalmonae is a malacosporean endoparasite that causes proliferative kidney disease (PKD) in wild and farmed salmonids in Europe and North America. The life cycle of T. bryosalmonae completes between ...

    • Identification of microRNAs from medicinal plant Murraya Koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis 

      Gutiérrez-García, Claudia; Ahmed, Shiek S. S. J.; Ramalingam, Sathishkumar; Selvaraj, Dhivya; Srivastava, Aashish; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2022)
      MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement in ...

    • Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders 

      Karadag, Naz; Shadrin, Alexey; O'Connell, Kevin S; Hindley, Guy Frederick Lanyon; Rahman, Zillur; Parker, Nadine; Bahrami, Shahram; Fominykh, Vera; Cheng, Weiqiu; Holen, Børge; Alvestad, Silje; Taubøll, Erik; Steen, Nils Eiel; Djurovic, Srdjan; Dale, Anders M; Frei, Oleksandr; Andreassen, Ole; Smeland, Olav Bjerkehagen (Journal article; Peer reviewed, 2023)
      Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity and overlapping symptoms. However, the causative mechanisms underlying this relationship are poorly understood. Here we aimed to ...

    • Identification of pleiotropy at the gene level between psychiatric disorders and related traits 

      Polushina, Tatiana; Banerjee, Niladri; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas; Lundervold, Astri J.; Djurovic, Srdjan; Cichon, Sven; Hoffmann, Per; Nöthen, Markus M.; Steen, Vidar Martin; Andreassen, Ole A.; Le Hellard, Stéphanie (Journal article; Peer reviewed, 2021)
      Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) ...

    • Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations 

      Bekken, Gry Klouman; Ritz, Christian; Selvam, Sumithra; Jesuraj, Nelson; Hesseling, Anneke; Doherty, T. Mark; Grewal, Harleen; Vaz, Mario; Jenum, Synne (Journal article; Peer reviewed, 2020-01-31)
      Background: The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as “asymptomatic, early pre-clinical ...

    • Identifying barriers and facilitators in HIV-indicator reporting for different health facility performances: A qualitative case study 

      Gesicho, Milka Bochere; Babic, Ankica (Journal article; Peer reviewed, 2021)
      Identifying barriers and facilitators in HIV-indicator reporting contributes to strengthening HIV monitoring and evaluation efforts by acknowledging contributors to success, as well as identifying weaknesses within the ...

    • Identifying logical evidence 

      Martin, Ben (Journal article; Peer reviewed, 2020-03-13)
      Given the plethora of competing logical theories of validity available, it’s understandable that there has been a marked increase in interest in logical epistemology within the literature. If we are to choose between these ...

    • Identifying major drivers of daily streamflow from large-scale atmospheric circulation with machine learning 

      Hagen, Jenny Sjåstad; Leblois, Etienne; Lawrence, Deborah; Solomatine, Dimitri; Sorteberg, Asgeir (Journal article; Peer reviewed, 2021)
      Previous studies linking large-scale atmospheric circulation and river flow with traditional machine learning techniques have predominantly explored monthly, seasonal or annual streamflow modelling for applications in ...

    • Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics 

      Lam, Max; Chen, Chia-Yen; Ge, Tian; Xia, Yan; Hill, David W.; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli A.; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri J.; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widen, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Koltai, Deborah; Need, AC; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson B.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Hellard, Stephanie Francoise Claire Le; Keller, Matthew C.; Andreassen, Ole; Deary, Ian J.; Glahn, David C.; Huang, Hailiang; Liu, Chunyu; Malhotra, Anil K.; Lencz, Todd (Journal article; Peer reviewed, 2021)
      Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. While novel drug targets for ...