• Clinical and Biological Factors Associated with Early Epstein-Barr Virus Infection in Human Immunodeficiency Virus-Exposed Uninfected Infants in Eastern Uganda 

      Montoya-Ferrer, Ana; Sanosyan, Armen; Fayd'Herbe De Maudave, Alexis; Pisoni, Amandine; Bollore, Karine; Molès, Jean-Pierre; Peries, Marianne; Tylleskär, Thorkild; Tumwine, James K.; Ndeezi, Grace; Gorgolas, Miguel; Nagot, Nicolas; Van De Perre, Philippe; Tuaillon, Edouard (Journal article; Peer reviewed, 2021)
      Background Immune control of Epstein-Barr virus (EBV) infection is impaired in individuals with HIV. We explored maternal factors associated with EBV acquisition in HIV-exposed uninfected (HEU) infants and the relationship ...
    • Design and challenges of a large HIV prevention clinical study on mother-to-child transmission: ANRS 12397 PROMISE-EPI study in Zambia and Burkina Faso 

      Mennecier, Anaïs; Kankasa, Chipepo; Fao, Paulin; Molès, Jean-Pierre; Eymard-Duvernay, Sabrina; Mwiya, Mwiya; Kania, Dramane; Chunda-Liyoka, Catherine; Sakana, Leticia; Rutagwera, David; Tassembedo, Souleymane; Wilfred-Tonga, Maria Melany; Mosqueira, Beatriz; Tylleskär, Thorkild; Nagot, Nicolas; Van De Perre, Philippe (Journal article; Peer reviewed, 2021)
      Post-natal HIV infection through breastfeeding remains a challenge in many low and middle-income countries, particularly due to non-availability of alternative infant feeding options and the suboptimal Prevention of Mother ...
    • Eliminating HIV transmission through breast milk from women taking antiretroviral drugs 

      Goga, Ameena; Van de Perre, Philippe; Ngandu, Nobubelo; Nagot, Nicolas; Abrams, Elaine J; Moodley, Dhayendre; King, Rachel; Molès, Jean-Pierre; Chirinda, Witness; Scarlatti, Gabriella; Tylleskär, Thorkild; Sherman, Gayle G; Pillay, Yogan; Dabis, François; Gray, Glenda (Journal article; Peer reviewed, 2021)
    • Eliminating postnatal HIV transmission in high incidence areas: need for complementary biomedical interventions 

      Van de Perre, Philippe; Goga, Ameena; Ngandu, Nobubelo; Nagot, Nicolas; Moodley, Dhayendre; King, Rachel; Molès, Jean-Pierre; Mosqueira, Beatriz; Chirinda, Witness; Scarlatti, Gabriella; Tylleskär, Thorkild; Dabis, François; Gray, Glenda (Journal article; Peer reviewed, 2021)
      The rate of mother-to-child transmission (MTCT) of HIV from breastfeeding is increasing relative to other causes of MTCT. Early effective preconception and antenatal antiretroviral therapy (ART) reduces intrauterine and ...
    • Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1‑year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life 

      Nagot, Nicolas; Singata-Madliki, Mandisa; Cournil, Amandine; Nalugya, Joyce; Tassembedo, Soleymane; Quillet, Catherine; Tonga, Melany W.; Tumwine, James K; Meda, Nicolas; Kankasa, Chipepo; Mwiya, Mwiya; Bangirana, Paul; Peries, Marianne; Batting, Joanne; Engebretsen, Ingunn Marie Stadskleiv; Tylleskär, Thorkild; Van de Perre, Philippe; Ndeezi, Grace; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      In the ANRS 12174 trial, HIV-exposed uninfected African neonates who received lopinavir-ritonavir (LPV/r) prophylaxis for 1 year exhibited slower growth from birth to week 50 compared with those receiving lamivudine (3TC). ...
    • Long-term persistence of mitochondrial DNA instability in HIV-exposed uninfected children during and after exposure to antiretroviral drugs and HIV 

      Desquiret-Dumas, Valérie; D’Ottavi, Morgana; Monnin, Audrey; Goudenège, David; Méda, Nicolas; Vizeneux, Amélie; Kankasa, Chipepo; Tylleskär, Thorkild; Bris, Céline; Procaccio, Vincent; Nagot, Nicolas; Van de Perre, Philippe; Reynier, Pascal; Molès, Jean-Pierre (Journal article; Peer reviewed, 2022)
      HIV-exposed uninfected (HEU) children show impaired health outcomes during childhood. A high rate of mitochondrial DNA (mtDNA) instability was reported in the blood of HEU at birth. We aimed to explore the relationship ...
    • Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis 

      Monnin, Audrey; Vizeneux, Amélie; Nagot, Nicolas; Eymard-Duvernay, Sabrina; Meda, Nicolas; Singata-Madliki, Mandisa; Ndeezi, Grace; Tumwine, James K; Kankasa, Chipepo; Goga, Ameena; Tylleskär, Thorkild; Van de Perre, Philippe; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of ...
    • Mitochondrial DNA Instability Is Common in HIV-Exposed Uninfected Newborns 

      Monnin, Audrey; Desquiret-Dumas, Valérie; Meda, Nicolas; Goudenège, David; Bris, Céline; Kankasa, Chipepo; Singata-Madliki, Mandisa; Tylleskär, Thorkild; Procaccio, Vincent; Nagot, Nicolas; Van De Perre, Philippe; Reynier, Pascal; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      Worldwide, one million HIV-exposed uninfected (HEU) children are born yearly, and chronic health impairments have been reported in these children. Mitochondrial DNA (mtDNA) instability and altered mtDNA content have been ...
    • Recurrent Severe Subclinical Mastitis and the Risk of HIV Transmission Through Breastfeeding 

      Rutagwera, David Gatsinzi; Molès, Jean-Pierre; Kankasa, Chipepo; Mwiya, Mwiya; Tuaillon, Edouard; Peries, Marianne; Nagot, Nicolas; Van de Perre, Philippe; Tylleskär, Thorkild (Journal article; Peer reviewed, 2022)
      Subclinical mastitis (SCM) is an important risk factor of postnatal HIV-1 transmission that is still poorly understood. A longitudinal sub-study of the ANRS12174 trial including 270 breastfeeding mothers in Lusaka, Zambia ...