Browsing University of Bergen Library by Author "Ueland, Per Magne"
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Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ... -
Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study
Van Parys, Anthea; Lysne, Vegard; Dierkes, Jutta; Nygård, Ottar Kjell; Øyen, Jannike; Vinknes, Kathrine Jørgensen; Karlsson, Therese; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Ueland, Per Magne; Brække, Maria Sandvik (Journal article; Peer reviewed, 2022)Background: Choline is an essential nutrient for humans and is involved in various physiologic functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and the fat-soluble choline ... -
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris
Bråtveit, Marianne; Parys, Anthea van; Olsen, Thomas; Strand, Elin; Marienborg, Ingvild; Laupsa-Borge, Johnny; Haugsgjerd, Teresa Risan; McCann, Adrian; Dhar, Indu; Ueland, Per Magne; Dierkes, Jutta; Dankel, Simon Erling Nitter; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2024)Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations ... -
The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study
Luu, Hung N.; Paragomi, Pedram; Wang, Renwei; Huang, Joyce Y.; Adams-Haduch, Jennifer; Midttun, Øivind; Ulvik, Arve; Nguyen, Tin C.; Brand, Randall E.; Gao, Yutang; Ueland, Per Magne; Yuan, Jian-Min (Journal article; Peer reviewed, 2022-04-28)Background: Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic ... -
Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging
Dugué, Pierre-Antoine; Hodge, Allison M.; Ulvik, Arve; Ueland, Per Magne; Midttun, Øyvind; Rinaldi, Sabina; MacInnis, Robert J.; Li, Sherly X.; Meyer, Klaus; Navionis, Anne-Sophie; Flicker, Leon; Severi, Gianluca; English, Dallas R.; Vineis, Paolo; Tell, Grethe S.; Southey, Melissa C.; Milne, Roger L.; Giles, Graham G. (Journal article; Peer reviewed, 2022)Background Inflammation is a key feature of aging. We aimed to (i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality and (ii) develop a signature of ... -
Association of Maternal Plasma Total Cysteine and Growth among Infants in Nepal: A Cohort Study
Arora, Nikhil; Strand, Tor A; Chandyo, Ram K; Elshorbagy, Amany; Shrestha, Laxman; Ueland, Per Magne; Ulak, Manjeswori; Schwinger, Catherine (Journal article; Peer reviewed, 2020)Cysteine is a semi-essential amino acid that has been positively associated with growth in children. However, transgenerational effects remain unclear. The aim of this analysis was to assess whether maternal plasma total ... -
Association of Plasma Total Cysteine and Anthropometric Status in 6–30 Months Old Indian Children
Schwinger, Catherine; Chowdhury, Ranadip; Sharma, Shakun; Bhandari, Nita; Taneja, Sunita; Ueland, Per Magne; Strand, Tor A (Journal article; Peer reviewed, 2020)High-quality protein has been associated with child growth; however, the role of the amino acid cysteine remains unclear. The aim was to measure the extent to which plasma total cysteine (tCys) concentration is associated ... -
Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis
Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine; Trøseid, Marius; Midttun, Øivind; Ueland, Per Magne; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Kummen, Martin; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)Background and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio ... -
Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.
Vikøren, Linn A.; Drotningsvik, Aslaug; Midttun, Øivind; McCann, Adrian; Bergseth, Marthe Tønder; Austgulen, Maren H.; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. ... -
Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children
Solvik, Beate Stokke; Øyen, Jannike; Kvestad, Ingrid; Markhus, Maria Wik; Ueland, Per Magne; McCann, Adrian; Strand, Tor Arne (Journal article; Peer reviewed, 2021)Background Biomarkers such as omega-3 (n–3) PUFAs, urinary iodine concentration (UIC), 1-methylhistidine (1-MH), and trimethylamine N-oxide (TMAO) have been associated with fish intake in observational studies, but data ... -
Biomarkers of inflammation and left ventricular remodelling in psoriasis patients treated with infliximab
Midtbø, Helga Bergljot; Kringeland, Ester Anne; Gerdts, Eva; Ueland, Per Magne; Meyer, Klaus; Linde, Anja G; Ulvik, Arve; Jonsson, Roland; Tveit, Kåre Steinar (Journal article; Peer reviewed, 2022)Objective: Psoriasis is an immune mediated disorder associated with T cell activation and cardiovascular disease (CVD). We explored the association of inflammation with left ventricular (LV) remodelling in psoriasis patients ... -
Breastfeeding and biomarkers of folate and cobalamin status in Norwegian infants: a cross-sectional study
Solvik, Beate Stokke; Bakken, Kjersti Sletten; McCann, Adrian; Ueland, Per Magne; Henjum, Sigrun; Strand, Tor Arne (Journal article; Peer reviewed, 2024)Folate and vitamin B12 (cobalamin) are essential for growth and development. This cross-sectional study aims to describe folate and vitamin B12 status according to infant age and breastfeeding practices in Norwegian infants. ... -
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients
Watne, Leiv Otto; Pollmann, Christian Thomas; Neerland, Bjørn Erik; Quist-Paulsen, Else; Halaas, Nathalie Bodd; Idland, Ane-Victoria; Hassel, Bjørnar; Henjum, Kristi; Knapskog, Anne Brita; Frihagen, Frede; Ræder, Johan; Godø, Aasmund; Ueland, Per Magne; McCann, Adrian; Figved, Paul Wender; Selbæk, Geir; Zetterberg, Henrik; Fei Fang, Evandro; Myrstad, Marius; Giil, Lasse Melvær (Journal article; Peer reviewed, 2022)Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ... -
Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease
Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Ørn, Stein; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ... -
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease
Bjørnestad, Espen Ø.; Olset, Hilde; Dhar, Indu; Løland, Kjetil Halvorsen; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Svardal, Asbjørn M.; Berge, Rolf K; Ueland, Per Magne; Tell, Grethe S.; Nilsen, Dennis W.T.; Jan E., Nordrehaug; Nygaard, Ellisif; Nygård, Ottar (Journal article; Peer reviewed, 2020)Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ... -
Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation
Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine; Reims, Henrik Mikael; Bjørk, Ida Torunn; Grzyb, Krzysztof; Abildgaard, Andreas; Småstuen, Milada Cvancarova; Folseraas, Trine; Trøseid, Marius; Ulvik, Arve; Ueland, Per Magne; Melum, Espen; Line, Pål Dag; Høivik, Marte Lie; Grønbæk, Henning; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2023)Background and aims We previously demonstrated that people with primary sclerosing cholangitis (PSC) had reduced gut microbial capacity to produce active vitamin B6 (pyridoxal 5’-phosphate [PLP]), which corresponded to ... -
Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal
Schwinger, Catherine; Sharma, Shakun; Chandyo, Ram K; Hysing, Mari; Kvestad, Ingrid; Ulak, Manjeswori; Ranjitkar, Suman; Shrestha, Merina; Shrestha, Laxman; McCann, Adrian; Ueland, Per Magne; Strand, Tor Arne (Journal article; Peer reviewed, 2021)The demand for cobalamin (vitamin B12) and folate is increased during pregnancy, and deficiency during pregnancy may lead to complications and adverse outcomes. Yet, the status of these micronutrients is unknown in many ... -
A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Clasen, Joanna L; Heath, Alicia K.; Van Puyvelde, Heleen; Huybrechts, Inge; Park, Jin Young; Ferrari, Pietro; Johansson, Mattias; Scelo, Ghislaine; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Dahm, Christina C; Halkjær, Jytte; Olsen, Anja; Johnson, Theron; Katzke, Verena; Schulze, Matthias B; Masala, Giovanna; Segrado, Francesco; De Magistris, Maria Santucci; Sacerdote, Carlotta; Ocké, Marga C; Luján-Barroso, Leila; Ching-López, Ana; Huerta, José María; Ardanaz, Eva; Amiano, Pilar; Ericson, Ulrika; Manjer, Jonas; Gylling, Björn; Johansson, Ingegerd; Schmidt, Julie; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J; Muller, David C (Journal article; Peer reviewed, 2021)Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. ... -
Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study
Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim; Midttun, Øivind; Ulvik, Arve; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2022)The transfer of one-carbon units between molecules in metabolic pathways is essential for maintaining cellular homeostasis, but little is known about whether the circulating concentrations of metabolites involved in the ... -
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice
O'Keeffe, Maria; Oterhals, Åge; Weishaupt, Hrafn; Leh, Sabine; Ulvik, Arve; Ueland, Per Magne; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)Purpose The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish ...