Blar i University of Bergen Library på forfatter "Vahokoski, Juha"
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Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers
Makumire, Stanley; Zininga, Tawanda; Vahokoski, Juha; Kursula, Inari; Shonhai, Addmore (Journal article; Peer reviewed, 2020)Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is thought to facilitate folding of select group of cellular proteins that are crucial for cyto-protection ... -
Durable immune responses after BNT162b2 vaccination in home-dwelling old adults
Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ... -
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia
Saghaug, Christina Skår; Gamlem, Astrid Leinebø; Hauge, Kirsti Brugrand; Vahokoski, Juha; Klotz, Christian; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt (Journal article; Peer reviewed, 2023)The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ... -
High-resolution structures of malaria parasite actomyosin and actin filaments
Vahokoski, Juha; Calder, Lesley J.; Moreno, Andrea Johana Lopez; Molloy, Justin E.; Kursula, Inari; Rosenthal, Peter B. (Journal article; Peer reviewed, 2022-04-04)Malaria is responsible for half a million deaths annually and poses a huge economic burden on the developing world. The mosquito-borne parasites (Plasmodium spp.) that cause the disease depend upon an unconventional ... -
Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3
Gartan, Parveen; Khorsand, Fahimeh; Mizar, Pushpak; Vahokoski, Juha; Cervantes, Luis F.; Haug, Bengt Erik; Brenk, Ruth; Brooks, Charles L.; Reuter, Nathalie (Journal article; Peer reviewed, 2024)Using a combination of multisite λ−dynamics (MSλD) together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase ... -
A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern
Ertesvåg, Nina Urke; Xiao, Julie; Zhou, Fan; Ljostveit, Sonja; Sandnes, Helene Heitmann; Lartey, Sarah; Sævik, Marianne; Hansen, Lena; Madsen, Anders; Mohn, Kristin Greve-Isdahl; Fjelltveit, Elisabeth Berg; Olofsson, Jan Stefan; Tan, Tiong Kit; Rijal, Pramilia; Schimanski, Lisa; Øyen, Siri; Brokstad, Karl Albert; Dunachie, Susanna; Jämsén, Anni; James, William S.; Harding, Adam C.; Harvala, Heli; Nguyen, Dung; Roberts, David; Patel, Monika; Gopal, Robin; Zambon, Maria; Wei, Leiyan; Gilbert-Jaramillo, Javier; Knight, Michael L.; Vaughan-Jackson, Alun; Dupont, Maeva; Lamikanra, Abigail A.; Klennerman, Paul; Townsend, Alain; Tøndel, Camilla; Kuwelker, Kanika; Blomberg, Bjørn; Bredholt, Geir; Onyango, Therese Bredholt; Vahokoski, Juha; Bansal, Amit; Trieu, Mai Chi; Amdam, Håkon; Akselsen, Per Espen; Skorge, Trude Duelien; Okkenhaug, Liv Heiberg; Linchausen, Dagrun Waag; Langeland, Nina; Cox Brokstad, Rebecca Jane (Journal article; Peer reviewed, 2022)Background: Evaluation of susceptibility to emerging SARS-CoV-2 variants of concern (VOC) requires rapid screening tests for neutralising antibodies which provide protection. Methods: Firstly, we developed a receptor-binding ... -
SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study
Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Zhou, Fan; Sævik, Marianne; Vahokoski, Juha; Brokstad, Karl Albert; Krammer, Florian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity ... -
Structure and function of Plasmodium actin II in the parasite mosquito stages
Lopez Moreno, Andrea Johana; Andreadaki, Maria; Vahokoski, Juha; Deligianni, Elena; Calder, Lesley J.; Camerini, Serena; Freitag, Anika; Bergmann, Ulrich; Rosenthal, Peter B.; Sidén-Kiamos, Inga; Kursula, Inari Talvikki (Journal article; Peer reviewed, 2023)Actins are filament-forming, highly-conserved proteins in eukaryotes. They are involved in essential processes in the cytoplasm and also have nuclear functions. Malaria parasites (Plasmodium spp.) have two actin isoforms ...