Blar i University of Bergen Library på tidsskrift "Biomolecules"

Viser treff 1-10 av 10

    • Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease 

      Flønes, Irene Hana; Nyland, Harald Inge; Sandnes, Dagny Ann; Alves, Guido Werner; Tysnes, Ole-Bjørn; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
      Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) ...

    • Endocan in Acute Leukemia: Current Knowledge and Future Perspectives 

      Reikvam, Håkon; Hatfield, Kimberley Joanne; Wendelbo, Øystein; Lindås, Roald; Lasalle, Phillip; Bruserud, Øystein (Journal article; Peer reviewed, 2022)
      Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high ...

    • Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD 

      Sverkeli, Lars Jansen; Hayat, Faisal; Migaud, Marie E.; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is ...

    • Insights from cardiopulmonary exercise testing in pediatric patients with hypertrophic cardiomyopathy 

      Gallo, Giovanna; Mastromarino, Vittoria; Limongelli, Giuseppe; Calcagni, Giulio; Maruotti, Antonello; Ragni, Luca; Valente, Fabio; Musumeci, Beatrice; Adorisio, Rachele; Rubino, Marta; Autore, Camillo; Magrì, Damiano (Journal article; Peer reviewed, 2021)
      The usefulness of cardiopulmonary exercise test (CPET) in adult hypertrophic cardiomyopathy (HCM) patients is well-known, whereas its role in pediatric HCM patients has not yet been explored. The present study investigates ...

    • Leaflet Tensions Control the Spatio-Temporal Remodeling of Lipid Bilayers and Nanovesicles 

      Lipowsky, Reinhard; Ghosh, Rikhia; Satarifard, Vahid; Sreekumari, Aparna; Zamaletdinov, Miftakh; Różycki, Bartosz; Miettinen, Markus; Grafmüller, Andrea (Journal article; Peer reviewed, 2023)
      Biological and biomimetic membranes are based on lipid bilayers, which consist of two monolayers or leaflets. To avoid bilayer edges, which form when the hydrophobic core of such a bilayer is exposed to the surrounding ...

    • Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment 

      Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)
      The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ...

    • Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis 

      Mosevoll, Knut Anders; Hansen, Bent-Are; Gundersen, Ingunn Margareetta; Reikvam, Håkon; Bruserud, Øyvind; Bruserud, Øystein; Wendelbo, Øystein (Journal article; Peer reviewed, 2023-01-24)
      Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The ...

    • Targeting the Class A Carbapenemase GES-5 via Virtual Screening 

      Klein, Raphael; Cendron, Laura; Montanari, Maria; Bellio, Pierangelo; Celenza, Giuseppe; Maso, Lorenzo; Tondi, Donatella; Brenk, Ruth (Journal article; Peer reviewed, 2020)
      The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A ...

    • Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 

      Qu, Heshuang; Heinbäck, Rebecka; Salo, Henna; Ewing, Ewoud; Espinosa, Alexander; Aulin, Cecilia; Harris, Anna Helena Erlandsson (Journal article; Peer reviewed, 2022-06-02)
      Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ...

    • Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25 

      Monnè, Magnus; Nikiforov, Andrey; Heiland, Ines; Agrimi, Gennaro; Ziegler, Mathias; Palmieri, Ferdinando (Journal article; Peer reviewed, 2021)
      Subcellular compartmentation is a fundamental property of eukaryotic cells. Communication and metabolic and regulatory interconnectivity between organelles require that solutes can be transported across their surrounding ...