Blar i University of Bergen Library på tidsskrift "eLIFE"
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An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae
(Journal article; Peer reviewed, 2022)The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process ... -
Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
(Journal article; Peer reviewed, 2022)Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight ... -
Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study
(Journal article; Peer reviewed, 2022)Background: Higher BMI in childhood is associated with emotional and behavioural problems, but these associations may not be causal. Results of previous genetic studies imply causal effects but may reflect influence of ... -
A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian
(Journal article; Peer reviewed, 2022)Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their ... -
Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci
(Journal article; Peer reviewed, 2020)Atlantic herring is widespread in North Atlantic and adjacent waters and is one of the most abundant vertebrates on earth. This species is well suited to explore genetic adaptation due to minute genetic differentiation at ... -
The effect of the COVID-19 pandemic on the gender gap in research productivity within academia
(Journal article; Peer reviewed, 2023)Using measures of research productivity to assess academic performance puts women at a disadvantage because gender roles and unconscious biases, operating both at home and in academia, can affect research productivity. The ... -
Heat shock factor 1 (Hsf1) cooperates with estrogen receptor α (erα) in the regulation of estrogen action in breast cancer cells
(Journal article; Peer reviewed, 2021)Heat shock factor 1 (HSF1), a key regulator of transcriptional responses to proteotoxic stress, was linked to estrogen (E2) signaling through estrogen receptor α (ERα). We found that an HSF1 deficiency may decrease ERα ... -
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
(Journal article; Peer reviewed, 2021)From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated ... -
Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication
(Journal article; Peer reviewed, 2021)Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation ... -
Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution
(Journal article; Peer reviewed, 2023)Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, ... -
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
(Journal article; Peer reviewed, 2021)Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the ... -
Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways
(Journal article; Peer reviewed, 2023)The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators ... -
Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells
(Journal article; Peer reviewed, 2021)Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale ... -
Transcriptional adaptation in caenorhabditis elegans
(Journal article; Peer reviewed, 2020-01)Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed ... -
The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution
(Journal article; Peer reviewed, 2020)Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First ...