Show simple item record

dc.contributor.authorBråte, Jon
dc.contributor.authorAdamski, Marcin
dc.contributor.authorNeumann, Ralf Stefan
dc.contributor.authorShalchian-Tabrizi, Kamran
dc.contributor.authorAdamska, Maja
dc.PublishedProceedings of the Royal Society of London. Biological Sciences 2015eng
dc.description.abstractLong non-coding RNAs (lncRNAs) play important regulatory roles during animal development, and it has been hypothesized that an RNA-based gene regulation was important for the evolution of developmental complexity in animals. However, most studies of lncRNA gene regulation have been performed using model animal species, and very little is known about this type of gene regulation in non-bilaterians. We have therefore analysed RNA-Seq data derived from a comprehensive set of embryogenesis stages in the calcareous sponge Sycon ciliatum and identified hundreds of developmentally expressed intergenic lncRNAs (lincRNAs) in this species. In situ hybridization of selected lincRNAs revealed dynamic spatial and temporal expression during embryonic development. More than 600 lincRNAs constitute integral parts of differentially expressed gene modules, which also contain known developmental regulatory genes, e.g. transcription factors and signalling molecules. This study provides insights into the non-coding gene repertoire of one of the earliest evolved animal lineages, and suggests that RNA-based gene regulation was likely present in the last common ancestor of animals.en_US
dc.publisherThe Royal Society Publishingeng
dc.rightsAttribution CC BYeng
dc.subjectIn cRNAeng
dc.subjectregulatory RNAeng
dc.titleRegulatory RNA at the root of animals: dynamic expression of developmental lincRNAs in the calcisponge Sycon ciliatumeng
dc.typeJournal articleeng
dc.typePeer reviewedeng
dc.rights.holderCopyright 2015 the authorseng
dc.relation.projectNorges forskningsråd: 213707

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY