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dc.contributor.authorSehring, Ivonne Margarete
dc.contributor.authorRecho, Pierre
dc.contributor.authorDenker, Elsa
dc.contributor.authorKourakis, Matthew
dc.contributor.authorMathiesen, Birthe Thuesen
dc.contributor.authorHannezo, Edouard
dc.contributor.authorDong, Bo
dc.contributor.authorJiang, Di
dc.PublishedeLIFE 2015, 4(e09206)eng
dc.description.abstractThe actomyosin cytoskeleton is a primary force-generating mechanism in morphogenesis, thus a robust spatial control of cytoskeletal positioning is essential. In this report, we demonstrate that actomyosin contractility and planar cell polarity (PCP) interact in post-mitotic Ciona notochord cells to self-assemble and reposition actomyosin rings, which play an essential role for cell elongation. Intriguingly, rings always form at the cells′ anterior edge before migrating towards the center as contractility increases, reflecting a novel dynamical property of the cortex. Our drug and genetic manipulations uncover a tug-of-war between contractility, which localizes cortical flows toward the equator and PCP, which tries to reposition them. We develop a simple model of the physical forces underlying this tug-of-war, which quantitatively reproduces our results. We thus propose a quantitative framework for dissecting the relative contribution of contractility and PCP to the self-assembly and repositioning of cytoskeletal structures, which should be applicable to other morphogenetic events.en_US
dc.rightsAttribution CC BYeng
dc.titleAssembly and positioning of actomyosin rings by contractility and planar cell polarityeng
dc.typeJournal articleeng
dc.typePeer reviewedeng
dc.rights.holderCopyright 2015 the authorseng

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