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dc.contributor.authorPrestegard, Siv Kristin
dc.contributor.authorOftedal, Linn Silje Wathne
dc.contributor.authorCoyne, Rosie Theresa
dc.contributor.authorNygård, Gyrid
dc.contributor.authorSkjærven, Kaja Helvik
dc.contributor.authorKnutsen, Gjert
dc.contributor.authorDøskeland, Stein Ove
dc.contributor.authorHerfindal, Lars
dc.PublishedMarine Drugs 2009, 7(4):605-623eng
dc.description.abstractIn spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in biofilm-associated diatoms sampled from the intertidal zone. Extracts from the genera Melosira, Amphora, Phaeodactylum and Nitzschia were all found to induce leukemia cell death, with either classical apoptotic or autophagic features. Several extracts also contained inhibitors of thrombin-induced blood platelet activation. Some of this activity was caused by a high content of adenosine in the diatoms, ranging from 0.07 to 0.31 μg/mg dry weight. However, most of the bioactivity was adenosine deaminase-resistant. An adenosine deaminase-resistant active fraction from one of the extracts was partially purified and shown to induce apoptosis with a istinct phenotype. The results show that benthic diatoms typically found in the intertidal zone may represent a richer source of interesting bioactive compounds than hitherto recognized.en_US
dc.rightsAttribution CC BYeng
dc.subjectAmphora sp.eng
dc.subjectblood plateletseng
dc.subjectdrug discoveryeng
dc.subjectPhaeodactylum tricornutumeng
dc.subjectMelosira sp.eng
dc.subjectnatural productseng
dc.subjectNitzshia pusillaeng
dc.titleMarine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activityen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2009 by the authorsen_US
dc.subject.nsiVDP::Medisinske fag: 700
dc.subject.nsiVDP::Midical sciences: 700

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