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dc.contributor.authorSandlund, Liv
dc.contributor.authorNilsen, Frank
dc.contributor.authorMale, Rune
dc.contributor.authorDalvin, Sussie
dc.PublishedMolecular and biochemical parasitology 2016, 208(2): 65-73eng
dc.description.abstractThe function of the ecdysone receptor (EcR) during development and molting has been thoroughly investigated in some arthropods such as insects but rarely in crustacean copepods such as the salmon louse Lepeophtheirus salmonis (L. salmonis) (Copepoda, Caligidae). The salmon louse is an ectoparasite on Atlantic salmon that has major economical impact in aquaculture due to the cost of medical treatment methods to remove lice from the fish. Handling of salmon louse infestations is further complicated by development of resistance towards available medicines. Understanding of basic molecular biological processes in the salmon louse is essential to enable development of new tools to control the parasite. In this study, we found L. salmonis EcR (LsEcR) transcript to be present in the neuronal somata of the brain, nuclei of muscle fibres and the immature intestine of the salmon louse. Furthermore, we explored the function of LsEcR during development using RNA interference mediated knock-down and through infection trials. Our results show that knock-down of LsEcR in the salmon louse is associated with hypotrophy of several tissues, delayed development and mortality. In addition, combined knock-down of LsEcR/LsRXR resulted in molting arrest during early larval stages.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.subjectSea liceeng
dc.subjectRNA interferenceeng
dc.subjectEcdysone receptoreng
dc.titleThe ecdysone receptor (EcR) is a major regulator of tissue development and growth in the marine salmonid ectoparasite, Lepeophtheirus salmonis (Copepoda, Caligidae)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Authorsen_US
dc.relation.projectNorges forskningsråd: 203513
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Parasittologi: 484
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Parasitology: 484

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