dc.contributor.author | Aksnes, Henriette | |
dc.contributor.author | Drazic, Adrian | |
dc.contributor.author | Marie, Michael Bruno Eric | |
dc.contributor.author | Arnesen, Thomas | |
dc.date.accessioned | 2017-06-01T08:31:06Z | |
dc.date.available | 2017-06-01T08:31:06Z | |
dc.date.issued | 2016-09 | |
dc.Published | Aksnes H, Drazic A, Marie MBE, Arnesen TA. First Things First: Vital Protein Marks by N-Terminal Acetyltransferases. TIBS -Trends in Biochemical Sciences. Regular ed. 2016;41(9):746-760 | eng |
dc.identifier.issn | 0968-0004 | en_US |
dc.identifier.uri | https://hdl.handle.net/1956/15909 | |
dc.description.abstract | N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein modification, but the recent discovery of Golgi- and chloroplast-resident N-terminal acetyltransferases (NATs) revealed that it can also be added post-translationally. Nt-acetylation may act as a degradation signal in a novel branch of the N-end rule pathway, whose functions include the regulation of human blood pressure. Nt-acetylation also modulates protein interactions, targeting, and folding. In plants, Nt-acetylation plays a role in the control of resistance to drought and in regulation of immune responses. Mutations of specific human NATs that decrease their activity can cause either the lethal Ogden syndrome or severe intellectual disability and cardiovascular defects. In sum, recent advances highlight Nt-acetylation as a key factor in many biological pathways. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Elsevier | en_US |
dc.relation.uri | http://www.sciencedirect.com/science/article/pii/S0968000416300779 | |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject | N-terminal acetyltransferase (NAT) | eng |
dc.subject | Nα-acetyltransferase (Naa) | eng |
dc.subject | N-terminal acetylation | eng |
dc.subject | protein interactions | eng |
dc.subject | protein folding | eng |
dc.subject | protein stability | eng |
dc.title | First Things First: Vital Protein Marks by N-Terminal Acetyltransferases | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2017-05-09T09:54:04Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2016 The Author(s) | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.tibs.2016.07.005 | |
dc.identifier.cristin | 1448261 | |
dc.source.journal | TIBS -Trends in Biochemical Sciences. Regular ed. | |