dc.contributor.author | Feng, Chungang | |
dc.contributor.author | Pettersson, Mats | |
dc.contributor.author | Lamichhaney, Sangeet | |
dc.contributor.author | Rubin, Carl-Johan | |
dc.contributor.author | Rafati, Nima | |
dc.contributor.author | Casini, Michele | |
dc.contributor.author | Folkvord, Arild | |
dc.contributor.author | Andersson, Leif | |
dc.date.accessioned | 2017-12-21T12:16:37Z | |
dc.date.available | 2017-12-21T12:16:37Z | |
dc.date.issued | 2017-06-30 | |
dc.Published | Feng C, Pettersson M, Lamichhaney S, Rubin C, Rafati N, Casini M, Folkvord A, Andersson L. Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate. eLIFE. 2017;6:e23907 | eng |
dc.identifier.issn | 2050-084X | en_US |
dc.identifier.uri | https://hdl.handle.net/1956/17079 | |
dc.description.abstract | The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (π = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 × 10-9 per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate – the lowest among vertebrates analyzed to date – partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity. | en_US |
dc.language.iso | eng | eng |
dc.publisher | eLife Sciences Publications | en_US |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.title | Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2017-12-01T12:13:02Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2017 The Author(s) | en_US |
dc.identifier.doi | https://doi.org/10.7554/elife.23907 | |
dc.identifier.cristin | 1495422 | |
dc.source.journal | eLIFE | |
dc.relation.project | Norges forskningsråd: 254774 | |