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dc.contributor.authorFeng, Chungang
dc.contributor.authorPettersson, Mats
dc.contributor.authorLamichhaney, Sangeet
dc.contributor.authorRubin, Carl-Johan
dc.contributor.authorRafati, Nima
dc.contributor.authorCasini, Michele
dc.contributor.authorFolkvord, Arild
dc.contributor.authorAndersson, Leif
dc.PublishedFeng C, Pettersson M, Lamichhaney S, Rubin C, Rafati N, Casini M, Folkvord A, Andersson L. Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate. eLIFE. 2017;6:e23907eng
dc.description.abstractThe Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (π = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 × 10-9 per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate – the lowest among vertebrates analyzed to date – partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity.en_US
dc.publishereLife Sciences Publicationsen_US
dc.rightsAttribution CC BYeng
dc.titleModerate nucleotide diversity in the Atlantic herring is associated with a low mutation rateen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)en_US
dc.relation.projectNorges forskningsråd: 254774

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