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dc.contributor.authorFeng, Chungang
dc.contributor.authorPettersson, Mats
dc.contributor.authorLamichhaney, Sangeet
dc.contributor.authorRubin, Carl-Johan
dc.contributor.authorRafati, Nima
dc.contributor.authorCasini, Michele
dc.contributor.authorFolkvord, Arild
dc.contributor.authorAndersson, Leif
dc.date.accessioned2017-12-21T12:16:37Z
dc.date.available2017-12-21T12:16:37Z
dc.date.issued2017-06-30
dc.PublishedFeng C, Pettersson M, Lamichhaney S, Rubin C, Rafati N, Casini M, Folkvord A, Andersson L. Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate. eLIFE. 2017;6:e23907eng
dc.identifier.issn2050-084Xen_US
dc.identifier.urihttps://hdl.handle.net/1956/17079
dc.description.abstractThe Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (π = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 × 10-9 per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate – the lowest among vertebrates analyzed to date – partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity.en_US
dc.language.isoengeng
dc.publishereLife Sciences Publicationsen_US
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleModerate nucleotide diversity in the Atlantic herring is associated with a low mutation rateen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2017-12-01T12:13:02Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Author(s)en_US
dc.identifier.doihttps://doi.org/10.7554/elife.23907
dc.identifier.cristin1495422
dc.source.journaleLIFE
dc.relation.projectNorges forskningsråd: 254774


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